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Lithium

PubChem CID: 3028194

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Compound Synonyms LITHIUM, 7439-93-2, LI, litio, CHEBI:30145, MFCD00134051, DTXSID5036761, Litium, Lithium Metal, Lithium, metallic, Lithium, elemental, MFCD00011074, Lithium 7, 3Li, HSDB 647, Lithium Standard: Li+ @ 1000 microg/mL in H2O, EINECS 231-102-5, Lithium Standard: Li @ 1000 microg/mL in 5% HNO3, Lithium Standard: Li @ 10000 microg/mL in 5% HNO3, monolithium, Lithium AA Standard: Li @ 1000 microg/mL in 5% HNO3, UNII-9FN79X2M3F, Lithium ribbon, Lithium rod, Normothymin-E, Normothymin-E (TN), LITHIUM, METAL, LITHIUM METALLICUM, Epitope ID:114079, EC 231-102-5, Lithium, 99%, low sodium, Lithium, 99%, high sodium, UNII-68KF447EX3, 9FN79X2M3F, LECTRO MAX POWDER 150, CHEMBL2146126, DTXCID101012138, AKOS015833388, AKOS015902481, FL49004, LITHIUM-6 METAL (6Li, 95%), Lithium wire, 3.2mm (0.125in) dia, Q568, Lithium granules, 1-6mm (0.04-0.2in), Lithium, granular, 99% trace metals basis, L0363, NS00076330, D08133, Lithium - Li @ 1000 microg/mL in 5% HNO3, Lithium hydride [UN1414] [Dangerous when wet], Lithium Standard: Li+ @ 100 microg/mL in H2O, Lithium - Li @ 1000 microg/g in Hydrocarbon Oil, Lithium - Li @ 5000 microg/g in Hydrocarbon Oil, Lithium Standard: Li @ 10 microg/mL in 2% HNO3, Lithium Standard: Li @ 1000 microg/g in Hydrocarbon Oil, Lithium Standard: Li @ 5000 microg/g in Hydrocarbon Oil, Lithium, AAS standard solution, Specpure?, Li 1000?g/ml, Lithium, ingot, diam. 5.7 cm, 99.9% trace metals basis, Lithium, rod, diam. 12.7 mm, 99.9% trace metals basis, Lithium Hollow Cathode Lamp: 1.5' Diameter, 2-pin, Non-Coded, Lithium Hollow Cathode Lamp: 2.0' Diameter, 4-pin, Cableless, Lithium Hollow Cathode Lamp: 2.0' Diameter, 9-pin, Non-Coded, Lithium hydride, fused solid [UN2805] [Dangerous when wet], Lithium, plasma standard solution, Specpure?, Li 10,000?g/ml, Lithium, plasma standard solution, Specpure?, Li 1000?g/ml, Lithium, rod, 12.7 mm diameter, length 165 mm, purity 99%, Lithium, rod, 12.7 mm diameter, length 200 mm, purity 99%, Lithium-6 Internal Standard: 6Li @ 10 microg/mL in 2% HNO3, Lithium, foil, 25x100mm, thickness 0.6mm, as rolled, 99.9%, Lithium-6 Internal Standard: 6Li @ 100 microg/mL in 2% HNO3, Lithium Nitrate Ionization Buffer: 1% Li (from carbonate) in 5% HNO3, Lithium, foil, thickness 0.6 mm, size 25 x 300 mm, purity 99.9%, Lithium, Ion chromatography standard solution, Specpure, Li+ 1000?g/ml, Sulfur-Free Lithium Standard: Li @ 1000 microg/g in Hydrocarbon Oil, Sulfur-Free Lithium Standard: Li @ 5000 microg/g in Hydrocarbon Oil, Lithium, foil, not light tested, 38x200mm, thickness 0.20mm, as rolled, 99.9%, Lithium, foil, not light tested, 38x500mm, thickness 0.20mm, as rolled, 99.9%, Lithium, foil, not light tested, 45x200mm, thickness 0.12mm, as rolled, 99.9%, Lithium, granular, 4-10 mesh particle size, high sodium, 99% (metals basis), Lithium, ribbon, thickness x W 0.38 mm x 23 mm, 99.9% trace metals basis, Lithium, ribbon, thickness x W 0.75 mm x 19 mm, 99.9% trace metals basis, Lithium, ribbon, thickness x W 0.75 mm x 45 mm, 99.9% trace metals basis, Lithium, ribbon, thickness x W 1.5 mm x 100 mm, 99.9% trace metals basis, 231-102-5
Topological Polar Surface Area 0.0
Hydrogen Bond Donor Count 0.0
Inchi Key WHXSMMKQMYFTQS-UHFFFAOYSA-N
Rotatable Bond Count 0.0
State Solid
Substituent Name Homogeneous alkali metal, Inorganic cation, Acyclic compound
Synonyms Apo-lithium carbonate, Apo-lithium carbonate SR, Carbolith Cap 150mg, Carbolith Cap 300mg, Carbolith Capsules 600mg, Eskalith, Eskalith CR, LI, Li(+), Li(+) cation, Li(+) ion, Li+, Lithane, Lithium atom, Lithium benziocum, Lithium carbonate, Lithium carbonicum, Lithium cation, Lithium citrate, Lithium element, Lithium ion, Lithium, ion, Lithium, ion (Li1+), lithium(+1) cation, lithium(1+), lithium(1+) ion, Lithium(I) cation, Lithobid, Pal-lithium carbonate, PHL-lithium carbonate, Pms-Lithium Carbonate - Cap 150mg, Pms-Lithium Carbonate - Cap 300mg, Pms-Lithium Carbonate - Cap 600mg, Pms-Lithium Citrate Syr 8mmo/5ml
Heavy Atom Count 1.0
Compound Name Lithium
Kingdom Inorganic compounds
Description Lithium (Li) is an alkali metal. First described as a mood stabilizer in 1949, it remains an efficacious treatment for bipolar disorders. Recent emerging evidence of its neuroprotective and neurogenic effects alludes to lithium's potential therapeutic use in stroke and neurodegenerative diseases. One intriguing clinical application is in the treatment of Alzheimer's disease. Ongoing clinical trials are evaluating lithium's abilities to lower tau and beta-amyloid levels in cerebrospinal fluid in Alzheimer's patients. Lithium reduces brain inositol levels by inhibiting the enzyme inositol monophosphatase. This suggests that inositol monophosphatase inhibition is a key mechanism of Li's therapeutic action and that design of new inositol monophosphatase inhibitors may be a practical strategy to create new compounds with Li-like therapeutic effects. Lithium reduces the severity of some behavioral complications of Alzheimer's disease (AD). And there are growing indications that Li may be of benefit to the underlying pathology of AD, as well as an array of other common CNS disorders, including stroke, Parkinson's disease, and Huntington's disease. Physiologically, it exists as an ion in the body. Despite these demonstrated and prospective therapeutic benefits, Li's mechanism of action remains elusive, and opinions differ regarding the most relevant molecular targets. Lithium inhibits several enzymes, significant among these are inositol monophosphatase (IMPase), glycogen synthase kinase-3 (GSK-3), and the proteasome. Lithium has a narrow therapeutic range, and several well characterised adverse effects limit the potential usefulness of higher doses. Acute ingestion in Li-naive patients is generally associated with only short-lived exposure to high concentrations, due to extensive distribution of Li throughout the total body water compartment. Conversely, chronic toxicity and acute-on-therapeutic ingestion are associated with prolonged exposure to higher tissue concentrations and, therefore, greater toxicity. Lithium toxicity may be life threatening, or result in persistent cognitive and neurological impairment. Therefore, enhanced Li clearance has been explored as a means of minimizing exposure to high tissue concentrations. Although haemodialysis is highly effective in removing circulating Li, serum concentrations often rebound so repeated or prolonged treatment may be required. Continuous arteriovenous haemodiafiltration and continuous venovenous haemodiafiltration increase Li clearance, albeit to a lesser extent than haemodialysis, and are more widely accessible. Lithium reduces brain inositol levels by inhibiting IMPase, suggesting that IMPase's inhibition is a key mechanism of Li's therapeutic action and that design of new IMPase inhibitors may be a practical strategy to create new compounds with Li-like therapeutic effects. (PMID: 17688381, 17316163, 8110911, 17288494). Lithium is found in many foods, some of which are endive, yellow zucchini, romaine lettuce, and common bean.
Exact Mass 7.016
Formal Charge 0.0
Monoisotopic Mass 7.016
Isotope Atom Count 0.0
Molecular Complexity 0.0
Hydrogen Bond Acceptor Count 0.0
Molecular Weight 7.0
Database Name fooddb_chem_all;pubchem
Covalent Unit Count 1.0
Enzyme Uniprot Id P49841, P35222
Defined Atom Stereocenter Count 0.0
Iupac Name lithium
Total Atom Stereocenter Count 0.0
Total Bond Stereocenter Count 0.0
Class Homogeneous alkali metal compounds
Inchi InChI=1S/Li
Smiles [Li]
Superclass Homogeneous metal compounds
Defined Bond Stereocenter Count 0.0
Molecular Formula Li

  • 1. Outgoing r'ship FOUND_IN to/from Allium Cepa (Plant) Rel Props:Source_db:fooddb_chem_all
  • 2. Outgoing r'ship FOUND_IN to/from Asparagus Officinalis (Plant) Rel Props:Source_db:fooddb_chem_all
  • 3. Outgoing r'ship FOUND_IN to/from Beta Vulgaris (Plant) Rel Props:Source_db:fooddb_chem_all
  • 4. Outgoing r'ship FOUND_IN to/from Brassica Oleracea (Plant) Rel Props:Source_db:fooddb_chem_all
  • 5. Outgoing r'ship FOUND_IN to/from Capsicum Annuum (Plant) Rel Props:Source_db:fooddb_chem_all
  • 6. Outgoing r'ship FOUND_IN to/from Capsicum Frutescens (Plant) Rel Props:Source_db:fooddb_chem_all
  • 7. Outgoing r'ship FOUND_IN to/from Cichorium Endivia (Plant) Rel Props:Source_db:fooddb_chem_all
  • 8. Outgoing r'ship FOUND_IN to/from Citrus Sinensis (Plant) Rel Props:Source_db:fooddb_chem_all
  • 9. Outgoing r'ship FOUND_IN to/from Cucumis Melo (Plant) Rel Props:Source_db:fooddb_chem_all
  • 10. Outgoing r'ship FOUND_IN to/from Cucumis Sativus (Plant) Rel Props:Source_db:fooddb_chem_all
  • 11. Outgoing r'ship FOUND_IN to/from Daucus Carota (Plant) Rel Props:Source_db:fooddb_chem_all
  • 12. Outgoing r'ship FOUND_IN to/from Lactuca Sativa (Plant) Rel Props:Source_db:fooddb_chem_all
  • 13. Outgoing r'ship FOUND_IN to/from Linum Usitatissimum (Plant) Rel Props:Source_db:fooddb_chem_all
  • 14. Outgoing r'ship FOUND_IN to/from Lycopersicon Esculentum (Plant) Rel Props:Source_db:fooddb_chem_all
  • 15. Outgoing r'ship FOUND_IN to/from Malus Domestica (Plant) Rel Props:Source_db:fooddb_chem_all
  • 16. Outgoing r'ship FOUND_IN to/from Petroselinum Crispum (Plant) Rel Props:Source_db:fooddb_chem_all
  • 17. Outgoing r'ship FOUND_IN to/from Phaseolus Vulgaris (Plant) Rel Props:Source_db:fooddb_chem_all
  • 18. Outgoing r'ship FOUND_IN to/from Prunus Domestica (Plant) Rel Props:Source_db:fooddb_chem_all
  • 19. Outgoing r'ship FOUND_IN to/from Prunus Persica (Plant) Rel Props:Source_db:fooddb_chem_all
  • 20. Outgoing r'ship FOUND_IN to/from Pyrus Communis (Plant) Rel Props:Source_db:fooddb_chem_all
  • 21. Outgoing r'ship FOUND_IN to/from Solanum Melongena (Plant) Rel Props:Source_db:fooddb_chem_all
  • 22. Outgoing r'ship FOUND_IN to/from Solanum Tuberosum (Plant) Rel Props:Source_db:fooddb_chem_all
  • 23. Outgoing r'ship FOUND_IN to/from Thymus Vulgaris (Plant) Rel Props:Source_db:fooddb_chem_all
  • 24. Outgoing r'ship FOUND_IN to/from Vitis Vinifera (Plant) Rel Props:Source_db:fooddb_chem_all
  • 25. Outgoing r'ship FOUND_IN to/from Zea Mays (Plant) Rel Props:Source_db:fooddb_chem_all
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