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Sikkimotoxin

PubChem CID: 3010626

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Compound Synonyms Sikkimotoxin, Sikkimotoxin [MI], UNII-P32T3N2QMR, 18651-67-7, P32T3N2QMR, Naphtho(2,3-C)furan-1(3H)-one, 3a,4,9,9a-tetrahydro-4-hydroxy-6,7-dimethoxy-9-(3,4,5-trimethoxyphenyl)-, (3aR,4R,9R,9aR)-, Naphtho(2,3-C)furan-1(3H)-one, 3a,4,9,9a-tetrahydro-4-hydroxy-6,7-dimethoxy-9-(3,4,5-trimethoxyphenyl)-, (3ar-(3aalpha,4alpha,9alpha,9abeta))-, Naphtho[2,3-c]furan-1(3H)-one, 3a,4,9,9a-tetrahydro-4-hydroxy-6,7-dimethoxy-9-(3,4,5-trimethoxyphenyl)-, (3aR,4R,9R,9aR)-, CHEMBL2288931, (3aR,4R,9R,9aR)-4-hydroxy-6,7-dimethoxy-9-(3,4,5-trimethoxyphenyl)-3a,4,9,9a-tetrahydro-3H-benzo[f][2]benzofuran-1-one, Q27286053, 6,7-O,O-DEMETHYLENE-6,7-O,O-DIMETHYLPODOPHYLLOTOXIN, (3aR)-3a,4,9,9aalpha-Tetrahydro-4beta-hydroxy-6,7-dimethoxy-9beta-(3,4,5-trimethoxyphenyl)naphtho[2,3-c]furan-, (3aR,4R,9R,9aR)-4-hydroxy-6,7-dimethoxy-9-(3,4,5-trimethoxyphenyl)-3a,4,9,9a-tetrahydro-3H-benzo[f]isobenzofuran-1-one, NAPHTHO(2,3-C)FURAN-1(3H)-ONE, 3A,4,9,9A-TETRAHYDRO-4-HYDROXY-6,7-DIMETHOXY-9-(3,4,5-TRIMETHOXYPHENYL)-, (3AR-(3A.ALPHA.,4.ALPHA.,9.ALPHA.,9A.BETA.))-
Ghose Rule True
Classyfire Kingdom Organic compounds
Topological Polar Surface Area 92.7
Hydrogen Bond Donor Count 1.0
Pfizer 3 75 Rule True
Scaffold Graph Level CC1CCC2CC3CCCCC3C(C3CCCCC3)C12
Np Classifier Class Arylnaphthalene and aryltetralin lignans
Deep Smiles COccc[C@H]O)[C@H]COC=O)[C@@H]5[C@@H]c9cc%13OC)))))cccOC))ccc6)OC)))OC
Heavy Atom Count 31.0
Classyfire Class Lignan lactones
Scaffold Graph Node Level OC1OCC2CC3CCCCC3C(C3CCCCC3)C21
Isotope Atom Count 0.0
Molecular Complexity 615.0
Database Name cmaup_ingredients;imppat_phytochem;npass_chem_all;pubchem
Defined Atom Stereocenter Count 4.0
Iupac Name (3aR,4R,9R,9aR)-4-hydroxy-6,7-dimethoxy-9-(3,4,5-trimethoxyphenyl)-3a,4,9,9a-tetrahydro-3H-benzo[f][2]benzofuran-1-one
Prediction Hob 1.0
Veber Rule True
Classyfire Superclass Lignans, neolignans and related compounds
Xlogp 2.1
Gsk 4 400 Rule False
Molecular Formula C23H26O8
Scaffold Graph Node Bond Level O=C1OCC2Cc3ccccc3C(c3ccccc3)C12
Prediction Swissadme 1.0
Inchi Key JQNGRAVMNACCCG-MGNXDGSBSA-N
Silicos It Class Moderately soluble
Fcsp3 0.4347826086956521
Rotatable Bond Count 6.0
Synonyms sikkimotoxin
Esol Class Soluble
Functional Groups CO, COC(C)=O, cOC
Compound Name Sikkimotoxin
Prediction Hob Swissadme 1.0
Exact Mass 430.163
Formal Charge 0.0
Monoisotopic Mass 430.163
Hydrogen Bond Acceptor Count 8.0
Molecular Weight 430.4
Gi Absorption True
Covalent Unit Count 1.0
Total Atom Stereocenter Count 4.0
Total Bond Stereocenter Count 0.0
Lipinski Rule Of 5 True
Esol -3.7474602129032273
Inchi InChI=1S/C23H26O8/c1-26-15-8-12-13(9-16(15)27-2)21(24)14-10-31-23(25)20(14)19(12)11-6-17(28-3)22(30-5)18(7-11)29-4/h6-9,14,19-21,24H,10H2,1-5H3/t14-,19+,20-,21-/m0/s1
Smiles COC1=CC(=CC(=C1OC)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](C4=CC(=C(C=C24)OC)OC)O
Np Classifier Biosynthetic Pathway Shikimates and Phenylpropanoids
Defined Bond Stereocenter Count 0.0
Egan Rule True
Np Classifier Superclass Lignans

  • 1. Outgoing r'ship FOUND_IN to/from Dimorphotheca Sinuata (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 2. Outgoing r'ship FOUND_IN to/from Dysosma Aurantiocaulis (Plant) Rel Props:Reference:ISBN:9780387706375
  • 3. Outgoing r'ship FOUND_IN to/from Schefflera Capitata (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 4. Outgoing r'ship FOUND_IN to/from Senecio Mexicanus (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 5. Outgoing r'ship FOUND_IN to/from Sinopodophyllum Hexandrum (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all