Nordazepam
PubChem CID: 2997
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| Compound Synonyms | Nordazepam, Nordiazepam, desmethyldiazepam, Norprazepam, 1088-11-5, N-Desmethyldiazepam, Calmday, N-Demethyldiazepam, N-Deoxydemoxepam, Madar, 1-Demethyldiazepam, N1-Desmethyldiazepam, Demethyldiazepam, Praxadium, Demadar, Stilny, Nordazepamum, Vegesan, N-Deoxydemoxapam, Nordazepam CIV, Ro 5-2180, Nordazepam [INN], Lomax, Sopax, DMDZ, 7-chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one, 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one, N-Descyclopropylmethylprazepam, Nordazepamum [INN-Latin], NSC 46078, A 101, 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-, Desoxydemoxepam, CCRIS 9181, A101, 7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one, EINECS 214-123-4, NSC-46078, Nordazepam (INN), Calmday (TN), NSC-631619, BRN 0751823, DTXSID2049000, CHEBI:111762, NORDAZEPAM [MI], Ro 52180, 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl-, CHEMBL523, 67220MCM01, NORDAZEPAM [MART.], NORDAZEPAM [WHO-DD], 7-Chlor-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-on, NDZ, DTXCID3028926, NORDAZEPAM CIV [USP-RS], 5-24-04-00291 (Beilstein Handbook Reference), NSC631619, NDD, NCGC00168263-01, Deoxydemoxepam, DIAZEPAM IMPURITY A [EP IMPURITY], Nordaz, 7-Chloro-1,3-dihydro-5-phenyl-(2H)-1,4-benzodiazepin-2-one, 7-Chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one, Nordazepamum (INN-Latin), NORDAZEPAM (MART.), 7-Chloro-5-phenyl-3H-1,4-benzodiazepin-2-one, Desmethyldiazepam (Nordazepam), DIPOTASSIUM CLORAZEPATE IMPURITY B [EP IMPURITY], NORDAZEPAM CIV (USP-RS), Nordazepam (1.0 mg/mL in Methanol), N-Destrifluoroethylhalazepam, Desmethyl Diazepam, DIAZEPAM IMPURITY A (EP IMPURITY), N-Descyclopropylmethyl-Prazepam, N Destrifluoroethylhalazepam, DIPOTASSIUM CLORAZEPATE IMPURITY B (EP IMPURITY), N Descyclopropylmethylprazepam, N Descyclopropylmethyl Prazepam, DEA No. 2838, UNII-67220MCM01, Ro 5 2180, Diazepam-M N-desmethyl, ChemDiv1_028362, MixCom6_000554, Oprea1_578139, SCHEMBL78453, MLS001173623, DivK1c_000979, SCHEMBL26104098, HMS503C19, HMS667J04, KBio1_000979, N05BA16, NINDS_000979, 7-chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one, HMS2272B05, NSC46078, Tox21_113493, BDBM50027835, STK560158, Desmethyldiazepam, analytical standard, WLN: T67 GMV JN IHJ CG KR, AKOS000636746, AKOS005486646, DB14028, IDI1_000979, SMR000238153, CAS-1088-11-5, 2H-1, 1,3-dihydro-7-chloro-5-phenyl-, 2H-1, 7-chloro-1,3-dihydro-5-phenyl-, DB-040846, 5-phenyl-7-chloro-1,4-benzodiazepin-2-one, NS00007814, 7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-ol, C07486, D08283, Nordazepam (Nordiazepam) 0.1 mg/ml in Methanol, Nordazepam (Nordiazepam) 1.0 mg/ml in Methanol, A801929, Desmethyldiazepam (Nordazepam), 1mg/ml in Methanol, Q3180288, 7-chloro-5-phenyl-1,3-dihydro-[1,4]benzodiazepin-2-one, 7-chloro-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one, (z)-7-chloro-5-phenyl-1h-benzo[e][1,4]diazepin-2(3h)-one, 7-chloro-1,3 -dihydro-5-phenyl-2H-1,4-benzodiazepine-2-one, 7-chloro-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one, 7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one #, 7-Chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one( am), 7-Chloro-5-phenyl-2-oxo-2,3-dihydro-1H-benzo[f]-1,4-diazepine, 7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (Nordazepam), 7-Chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one(nordiazepam), 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one, Nordazepam, Nordiazepam, 7-Chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one(desmethyldiazepam), 214-123-4 |
|---|---|
| Topological Polar Surface Area | 41.5 |
| Hydrogen Bond Donor Count | 1.0 |
| Inchi Key | AKPLHCDWDRPJGD-UHFFFAOYSA-N |
| Rotatable Bond Count | 1.0 |
| Synonyms | 1-Demethyldiazepam, 2H-1,4-Benzodiazepin-2-one, 1, 3-dihydro-7-chloro-5-phenyl-, 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl-, 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-, 5-phenyl-7-chloro-1,4-benzodiazepin-2-one, 7-Chlor-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-on, 7-Chloro-1, 3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one, 7-Chloro-1,3-dihydro-5-phenyl-(2H)-1,4-benzodiazepin-2-one, 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one, 7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one, 7-Chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one, Calmday, Chlordesmethyldiazepam, Clorazepate (break down), Dealkylprazepam, Demadar, Demethyldiazepam, Deoxydemoxepam, Desalkylprazepam, Desmethyldiazepam, DMDZ, Lomax, Madar, N-demethyldiazepam, N-deoxydemoxapam, N-deoxydemoxepam, N-desalkylhalazepam, N-descyclopropylmethyl-prazepam, N-descyclopropylmethylprazepam, N-desmethyldiazepam, N-destrifluoroethylhalazepam, N1-Desmethyldiazepam, NDD, NDZ, Nordaz, Nordazepam, Nordazepam [inn], Nordazepamum, Nordiazepam, Norprazepam, Praxadium, Sopax, Stilny, Vegesan, N-Demethyldiazepam, N-Deoxydemoxepam, N-Desmethyldiazepam, N-Descyclopropylmethylprazepam, Tranxilium N, N Descyclopropylmethyl prazepam, N Desalkylhalazepam, N Destrifluoroethylhalazepam, N Descyclopropylmethylprazepam, N-Descyclopropylmethyl-prazepam, N-Destrifluoroethylhalazepam, N-Desalkylhalazepam |
| Heavy Atom Count | 19.0 |
| Compound Name | Nordazepam |
| Kingdom | Organic compounds |
| Description | N-demethyldiazepam, also known as nordiazepam or calmday, is a member of the class of compounds known as 1,4-benzodiazepines. 1,4-benzodiazepines are organic compounds containing a benzene ring fused to a 1,4-azepine. N-demethyldiazepam is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). N-demethyldiazepam can be found in common wheat, corn, and potato, which makes N-demethyldiazepam a potential biomarker for the consumption of these food products. N-demethyldiazepam can be found primarily in blood and urine, as well as in human kidney and liver tissues. N-demethyldiazepam is a non-carcinogenic (not listed by IARC) potentially toxic compound. General supportive measures should be employed, along with intravenous fluids, and an adequate airway maintained. Hypotension may be combated by the use of norepinephrine or metaraminol. Dialysis is of limited value. Flumazenil (Anexate) is a competitive benzodiazepine receptor antagonist that can be used as an antidote for benzodiazepine overdose. In particular, flumazenil is very effective at reversing the CNS depression associated with benzodiazepines but is less effective at reversing respiratory depression. Its use, however, is controversial as it has numerous contraindications. It is contraindicated in patients who are on long-term benzodiazepines, those who have ingested a substance that lowers the seizure threshold, or in patients who have tachycardia or a history of seizures. As a general rule, medical observation and supportive care are the mainstay of treatment of benzodiazepine overdose. Although benzodiazepines are absorbed by activated charcoal, gastric decontamination with activated charcoal is not beneficial in pure benzodiazepine overdose as the risk of adverse effects often outweigh any potential benefit from the procedure. It is recommended only if benzodiazepines have been taken in combination with other drugs that may benefit from decontamination. Gastric lavage (stomach pumping) or whole bowel irrigation are also not recommended (T3DB). |
| Exact Mass | 270.056 |
| Formal Charge | 0.0 |
| Monoisotopic Mass | 270.056 |
| Isotope Atom Count | 0.0 |
| Molecular Complexity | 376.0 |
| Hydrogen Bond Acceptor Count | 2.0 |
| Molecular Weight | 270.71 |
| Database Name | fooddb_chem_all;hmdb_chem_all;npass_chem_all;pubchem |
| Covalent Unit Count | 1.0 |
| Uniprot Id | P16257, P30536, Q16445, P16305, P02768, P02763, n.a., O75496, P10275 |
| Defined Atom Stereocenter Count | 0.0 |
| Iupac Name | 7-chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one |
| Total Atom Stereocenter Count | 0.0 |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Total Bond Stereocenter Count | 0.0 |
| Class | Benzodiazepines |
| Inchi | InChI=1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19) |
| Smiles | C1C(=O)NC2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3 |
| Xlogp | 2.9 |
| Superclass | Organoheterocyclic compounds |
| Defined Bond Stereocenter Count | 0.0 |
| Subclass | 1,4-benzodiazepines |
| Taxonomy Direct Parent | 1,4-benzodiazepines |
| Molecular Formula | C15H11ClN2O |
- 1. Outgoing r'ship
FOUND_INto/from Solanum Tuberosum (Plant) Rel Props:Source_db:fooddb_chem_all - 2. Outgoing r'ship
FOUND_INto/from Triticum Aestivum (Plant) Rel Props:Source_db:fooddb_chem_all - 3. Outgoing r'ship
FOUND_INto/from Zea Mays (Plant) Rel Props:Source_db:fooddb_chem_all