Clotrimazole
PubChem CID: 2812
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| Compound Synonyms | clotrimazole, 23593-75-1, Lotrimin, Canesten, Mycelex, Clotrimazol, Mycosporin, Empecid, Mykosporin, Gyne lotrimin, Chlotrimazole, Trimysten, Gyne-Lotrimin, Mycelex G, Rimazole, Gynix, Mono-baycuten, Mycelex Troches, 1-(o-Chlorotrityl)imidazole, Pedisafe, Mycelex 7, Tibatin, Lotrimin AF Cream, Lotrimin Af, Trivagizole 3, Desamix F, Mycelex-G, 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole, Mycelex OTC, Clotrimazolum, Gyne-Lotrimin 3, Canestine, Monobaycuten, Mycelex-7, Canifug, (Chlorotrityl)imidazole, Fem Care, Mycofug, BAY 5097, BAY b 5097, Mycelex-7 Combination Pack, Canestene, Clomatin, Cutistad, Lotrimax, Lotrimin AF Jock-Itch Cream, Stiemazol, Esparol, Mycelax, Nalbix, Gino-Lotremine, Gyne-Lotrimin Combination Pack, Pan-Fungex, 1-(o-Chloro-alpha,alpha-diphenylbenzyl)imidazole, Gyne-Lotrimin 3 Combination Pack, Bay-B 5097, clotrimeizol, Trivagizole, Jidesheng, 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole, 1-(o-Chlorophenyldiphenylmethyl)imidazole, (2-Chlorophenyl)diphenyl-1-imidazolylmethane, NSC 257473, 1H-Imidazole, 1-[(2-chlorophenyl)diphenylmethyl]-, Diphenyl(2-chlorophenyl)(1-imidazolyl)methane, Diphenyl-(2-chlorophenyl)-1-imidazolylmethane, FB 5097, Lotrimin (TN), 1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole, Mycelex (TN), Clotrimazol [INN-Spanish], Clotrimazolum [INN-Latin], DRG-0072, chlortrimazole, 1-[(2-chlorophenyl)-diphenylmethyl]imidazole, GNF-Pf-3499, CCRIS 6245, B 5097, HSDB 3266, Bis-phenyl-(2-chlorophenyl)(1-imidazoyl)methane, 1H-Imidazole, 1-((2-chlorophenyl)diphenylmethyl)-, Mycelex: MycosporinRimazole, Methane, bis-phenyl-(2-chlorophenyl)-1-imidazolyl-, EINECS 245-764-8, Bay b 9057, MFCD00057220, NSC257473, 1-(2-chlorotrityl)imidazole, Bisphenyl-(2-chlorphenyl)-1-imidazolyl-methan, Prestwick_120, NSC-257473, UNII-G07GZ97H65, BRN 0622318, CHEBI:3764, 1-[(2-chlorophenyl)(diphenyl)methyl]-1H-imidazole, DTXSID7029871, G07GZ97H65, 1-((o-Chloro-phenyl)diphenylmethyl)imidazole, BAY-5097, Bis-fenil-(2-clorofenil)-1-imidazolil-metano, Lopac-C-6019, SVT-15652, CHEMBL104, MLS000028502, DTXCID009871, Klotrimazole, 1-[(2-chlorophenyl)-diphenyl-methyl]imidazole, 5-23-04-00291 (Beilstein Handbook Reference), Imidazole, 1-(o-chloro-alpha,alpha-diphenylbenzyl)-, 1-(o-Chloro-.alpha.,.alpha.-diphenylbenzyl)imidazole, LOTRISONE COMPONENT CLOTRIMAZOLE, Clotrimazole [USAN:USP:INN:BAN:JAN], NCGC00015251-02, Clotrimaderm, SMR000058306, FemCare, Lotrimin Lotion, Canesten Cream, CAS-23593-75-1, Clotrimazole 100 microg/mL in Acetonitrile, Lotrimin Cream, Mycelex Cream, Myclo Cream, Myclo-Gyne, Clotrimazol (INN-Spanish), Clotrimazolum (INN-Latin), Neo-Zol Cream, Bis-phenyl-(2-chlorophenyl)-1-imidazoyl)methane, Mycelex Twin Pack, CLOTRIMAZOLE (MART.), CLOTRIMAZOLE [MART.], Lotrimin AF Lotion, CLOTRIMAZOLE (USP-RS), CLOTRIMAZOLE [USP-RS], CLOTRIMAZOLE (EP IMPURITY), CLOTRIMAZOLE [EP IMPURITY], CLOTRIMAZOLE (EP MONOGRAPH), CLOTRIMAZOLE (USP IMPURITY), CLOTRIMAZOLE [EP MONOGRAPH], CLOTRIMAZOLE [USP IMPURITY], Canesten 1-Day Therapy, Canesten 3-Day Therapy, Canesten 6-Day Therapy, CLOTRIMAZOLE (USP MONOGRAPH), CLOTRIMAZOLE [USP MONOGRAPH], Clotrimazole (USAN:USP:INN:BAN:JAN), Canesten 1-Day Cream Combi-Pak, Canesten Combi-Pak 1-Day Therapy, Canesten Combi-Pak 3-Day Therapy, SR-01000075771, 1-((2-chlorophenyl)(diphenyl)methyl)-1H-imidazole, clortrimazole, clotrimazolo, Coltrimazole, Alevazol, Femmesil, Footlogix, Fortinia, Lakesia, Pedesil, Ringworm, Otomax, SilkaRingworm, UpandUp, HEBAntifungal, Mycelex Troche, Ringworm Cream, Clotrima Top, Fungistat Max, KrogerJock Itch, TM-Clotrimazole, Cura Hongo, TopCareAntifungal, Athlete s Foot, Fortinia OF, Gyne-Lotrimin3, Micotrin AC, Clotrimazole 1%, CVS Clotrimazole, DermatinAntifungal, FungicureIntensive, Mycozyl AC, ringworm treatment, Votriza-AL, Equate Jock Itch, Rexall Jock Itch, Clotrimaderm Cream, Drs. Clotrimazole, Dynarex Antifungal, Fungazoil Advanced, Major Clotrimazole, WalgreensJock Itch, Anti-Fungal Cream, Clotrimazole,(S), Publixathletic foot, UpandUpClotrimazole, meijerAthletes Foot, Shoprite Antifungal, Athlete s FootAfac, Jock ItchAntifungal, Clotrimazole topical, Hua Tuo Xian Gao, Aspiera Anti-fungal, CAREONEClotrimazole, Cura HongoAntifungal, Cvshealth Antifungal, Zapotol Clotrimazole, meijerClotrimazole 3, PRO-EXAnti Fungal, CANESTENV, CLOT, ClotrimazoleJock Itch, Fungicure Liquid Gel, Oheal Ringworm Cream, Rexall Athletes Foot, Shopko Athletes Foot, Clotrimazole 1.0%, sunmarkClotrimazole 3, CAREALL Clotrimazole, lmnoop tinea treatment, PerfectHeal Antifungal, Topcare Athletes Foot, TopCareClotrimazole 3, Walgreens Clotrimazole, Bis-fenil-(2-clorofenil)-1-imidazolil-metano [Italian], Bisphenyl-(2-chlorphenyl)-1-imidazolyl-methan [German], Clotrimazoil Antifungal, Clotrimazole Antifungal, CVSAntifungal Ringworm, Foot Care Clotrimazole, lmnoop jock itch cream, Best ChoiceClotrimazole, CLOTRIMAZOL DUAL, JOCK-EZE, PedesilMaximum Strength, WinCo Foods Antifungal, Clotrimazole Cream 1%, KrogerATHLETES FOOT, Spectrum_001343, WalgreensClotrimazole 3, CPD000058306, PRO-EX, AKIN ANTI-FUNGAL, Clotrimazole (Canesten), Clotrimazole (Standard), Our FamilyAthletes Foot, Signature CareJock Itch, up and up athletes foot, ClotrimazoleAthletes Foot, Terrasil Tinea Treatment, Astonea Clotrimazole 1%, TerrasilMed ANTIFUNGAL, Good Sense Athletes Foot, Prestwick0_000267, Prestwick1_000267, Prestwick2_000267, Prestwick3_000267, Spectrum2_000128, Spectrum3_000359, Spectrum4_000295, Spectrum5_000781, CLOTRIMAZOLE [MI], Healthy Accents Antifungal, lmnoop athletes foot Cream, Manuka Honey Eczema Cream, CLOTRIMAZOLE [INN], CLOTRIMAZOLE [JAN], SUNMARK CLOTRIMAZOLE, Dr Sheffield Athletes Foot, Quality Choice Clotrimazole, Rite Aidantifungal ringworm, Terrasil Ringworm Treatment, C 6019, CLOTRIMAZOLE [USAN], CVS PharmacyClotrimazole 3, iShancare ringworm treatment, NCIMech_000609, Western FamilyAthletes Foot, cid_2812, SCHEMBL3850, Terrasil Tinea TreatmentMAX, Family Wellness Clotrimazole, Forticept Antifungal Cooling, CLOTRIMAZOLE [VANDF], Lucky SuperSoftAthletes Foot, BIDD:PXR0036, ishancare jock itch treatment, Lopac0_000315, Quality Choice Athletes Foot, Terrasil Jock-Itch Treatment, Up and Up Jock Itch Relief, BSPBio_000114, BSPBio_002057, Clotrimazole 1%Athletes Foot, ishancare athletes foot Cream, KBioGR_000850, KBioSS_001823, Forticept Antifungal Foot Gel, MLS000758243, MLS001423972, BIDD:GT0450, Budpak Antifungal Clotrimazole, CLOTRIMAZOLE [WHO-DD], DivK1c_000665, GOODSENSE ATHLETES FOOT, Meijer Clotrimazole Antifungal, SPECTRUM1500200, BAY b5097, BAYb 5097, Exchange Select Atheletes foot, Fastrin Anti-Fungal Skin Care, ishancare anti-fungal treatment, lmnoop serious antifungal cream, Smooth Gator Fungus Eliminator, SPBio_000176, SPBio_002333, Terrasil Anti-fungal Treatment, Terrasil Ringworm TreatmentMAX, Atopalm Clotrimazole Antifungal, AU KAH CHUEN ANTIFUNGAL, Clotrimazole Transdermal Liquid, Meijer Athletes Foot Cream AF, Veltrim 1% Dermatologic Cream, BPBio1_000126, Forticept Antifungal Foot Cream, GTPL2330, Leader Clotrimazole Anti-fungal, Jock ItchClotrimazole Antifungal, component of Otomax (Salt/Mix), CVS ClotrimazoleMaximum Strength, Gyne-Lotrimin3 Combination Pack, Oheal Manuka Honey Eczema Cream, SIMPLY VITAL Antifungal Cream, Terrasil Jock-Itch TreatmentMAX, BDBM31774, Clotrimazole (JP18/USP/INN), HMS502B07, KBio1_000665, KBio2_001823, KBio2_004391, KBio2_006959, KBio3_001277, Soundbody Clotrimazole Antifungal, Terrasil Rapid-clear Anti-fungal, Walgreens Clotrimazole Antifungal, A01AB18, Blossom Pharmaceuticals Antifungal, CLOTRIMAZOLE [GREEN BOOK], Clotrimazole 1% Antifungal Cream, D01AC01, G01AF02, Imidazole, 1-(o-chloro-.alpha.,.alpha.-diphenylbenzyl)-, Athletes Foot AntifungalAntifungal, component of Lotrimax (Salt/Mix), Good Neighbor PharmacyClotrimazole, Jock Itch Cream with Clotrimazole, NINDS_000665, Terrasil Anti-Fungal TreatmentMAX, Thera plus Antifungal Clotrimazole, CLOTRIMAZOLE [ORANGE BOOK], Good Sense Athletes Footantifungal, HMS1568F16, HMS1920O21, HMS2051E11, HMS2091G10, HMS2095F16, HMS2235E20, HMS3260P12, HMS3369I03, HMS3393E11, HMS3655I09, HMS3712F16, Pharmakon1600-01500200, HUA TUO XIAN GAO ANTIFUNGAL, Imidazole,.alpha.-diphenylbenzyl)-, Rugby Clotrimazole Antifungal Cream, Terrasil Foot and Nail Anti-fungal, Aardora Anti-FungalMaximum Strength, BCP02150, Clotrimazole for peak identification, First Aid Research Antifungal .5oz, KXB07641, MSK21152, RUGBY ANTIFUNGAL CLOTRIMAZOLE, Tox21_110111, Tox21_300415, Tox21_500315, Astonea Clotrimazole 1%Athletes Foot, Athlete Foot Cream with Clotrimazole, CCG-35563, Good Neighbor PharmacyClotrimazole 3, HY-10882R, NSC756700, s1606, STK700023, AKOS005607024, Fungicure Manicure Pedicure Liquid Gel, Tox21_110111_1, 1MED Clotrimazole 1% Antifungal Cream, Clotrimazole Topical Solution USP, 1%, CS-1926, CVS PharmacyITCH RELIEF ANTIFUNGAL, DB00257, FC20523, footlogix intensive carediabetic formula, LP00315, NC00035, NSC-756700, SB17418, SDCCGSBI-0050303.P005, Fungicure Manicure Pedicure Anti Fungal, IDI1_000665, LEADER ATHLETES FOOT CLOTRIMAZOLE, MRF-0000070, QTL1_000024, APTRIMAZOLE1.0% ANTIFUNGAL CREAM, Clotrimazole 1% Topical Antifungal Cream, First Aid Research Antifungal Cream 1oz, NCGC00015251-01, NCGC00015251-03, NCGC00015251-04, NCGC00015251-05, NCGC00015251-06, NCGC00015251-07, NCGC00015251-08, NCGC00015251-09, NCGC00015251-10, NCGC00015251-11, NCGC00015251-12, NCGC00015251-13, NCGC00015251-14, NCGC00015251-27, NCGC00093761-01, NCGC00093761-02, NCGC00093761-03, NCGC00093761-04, NCGC00093761-05, NCGC00093761-06, NCGC00254538-01, NCGC00261000-01, 117829-71-7, 1ST21152, AS-13816, CLOTRIMAZOLE COMPONENT OF LOTRISONE, HY-10882, OcculusSkin Hydrating Topical Foam CLO-1, SY051361, Terrasil Tinea Treatment Maximum Strength, SBI-0050303.P004, Terrasil Antifungal Cream Maximum Strength, DB-046195, 1-[(2-Chlorophenyl)diphenylmethyl]imidazole, AB00051951, C2867, EU-0100315, NS00000282, SW196431-5, Terrasil JockItch Treatment Maximum Strength, Botanimedix TineaRX Antifungal Drying Emulsion, Terrasil Jock Itch Treatment Maximum Strength, C06922, D00282, Terrasil Athletes Foot AntiFungal Treatment Max, 1-(.alpha.-(2-Chlorophenyl)benzhydryl)imidazole, 1-[(2-chlorophenyl)-di(phenyl)methyl]imidazole, AB00051951-14, AB00051951_15, AB00051951_16, Clotrimazole, VETRANAL(TM), analytical standard, EN300-7409200, A816789, Q413546, Terrasil Foot and Nail Anti-FungalMaximum Strength, 1H-Imidazole, 1-[(2-chlorophenyl)-diphenylmethyl], SR-01000075771-1, SR-01000075771-6, SR-01000075771-8, 1-[(2-Chloro-phenyl)-diphenyl-methyl]-1H-imidazole, BRD-K15916496-001-14-7, BRD-K15916496-001-26-1, BRD-K15916496-001-27-9, SR-01000075771-10, 3ACDFDF8-38E3-4368-85D0-BDF8AE1E6591, Clotrimazole, British Pharmacopoeia (BP) Reference Standard, Clotrimazole, European Pharmacopoeia (EP) Reference Standard, OcculusSKIN HYDRATING TOPICAL FOAM CLO-1 ANTIFUNGAL FOAM, Clotrimazole, United States Pharmacopeia (USP) Reference Standard, 1-[(2-Chlorophenyl)-diphenyl-methyl]-1H-imidazole, FB-5097, Bay B 5097, 1-(o-Chlorotrityl)imidazole, 1-(o-Chloro-alpha,alpha-diphenylbenzyl)imidazole, Clotrimazole for peak identification, European Pharmacopoeia (EP) Reference Standard, Clotrimazole, Pharmaceutical Secondary Standard, Certified Reference Material, 245-764-8 |
|---|---|
| Topological Polar Surface Area | 17.8 |
| Hydrogen Bond Donor Count | 0.0 |
| Heavy Atom Count | 25.0 |
| Description | Clotrimazole is an imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. -- Pubchem, There is the potential for drug interactions with Clotrimazole if taken orally, as it is a potent, specific inhibitor of cytochrome P450 oxidase enzymes and so may alter the metabolism of other drugs., Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. -- Wikipedia, An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane., Clotrimazole is a potent, specific inhibitor of cytochrome P450 oxidase enzymes. Hence, it may alter the metabolism of other drugs particularly if taken orally. -- Wikipedia, Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. It also used to treat athlete's foot and jock itch. [HMDB] |
| Isotope Atom Count | 0.0 |
| Molecular Complexity | 396.0 |
| Database Name | cmaup_ingredients;fooddb_chem_all;pubchem |
| Defined Atom Stereocenter Count | 0.0 |
| Enzyme Uniprot Id | P24539, Q13443, Q5VTU8 |
| Iupac Name | 1-[(2-chlorophenyl)-diphenylmethyl]imidazole |
| Prediction Hob | 0.0 |
| Class | Benzene and substituted derivatives |
| Target Id | NPT2683, NPT3159, NPT109, NPT668, NPT2217, NPT2854, NPT441, NPT98, NPT235, NPT1647, NPT237, NPT540, NPT4506, NPT2691, NPT213, NPT110, NPT212, NPT208, NPT628, NPT3604, NPT613, NPT713, NPT4582 |
| Xlogp | 5.0 |
| Superclass | Benzenoids |
| Subclass | Halobenzenes |
| Molecular Formula | C22H17ClN2 |
| Prediction Swissadme | 0.0 |
| Inchi Key | VNFPBHJOKIVQEB-UHFFFAOYSA-N |
| Fcsp3 | 0.0454545454545454 |
| Logs | -6.539 |
| Rotatable Bond Count | 4.0 |
| State | Solid |
| Logd | 4.205 |
| Synonyms | (Chlorotrityl)imidazole, 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole, 1-(a-(2-Chlorophenyl)benzhydryl)imidazole, 1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole, 1-(O-chloro-a,a-Diphenylbenzyl)imidazole, 1-(O-chloro-alpha,alpha-Diphenylbenzyl)imidazole, 1-(O-chloro-α,α-diphenylbenzyl)imidazole, 1-(o-Chlorotrityl)imidazole, 1-(α-(2-chlorophenyl)benzhydryl)imidazole, Canesten, Canesten 1-Day Cream Combi-Pak, Canesten 1-Day Therapy, Canesten 3-Day Therapy, Canesten 6-Day Therapy, Canesten Combi-Pak 1-Day Therapy, Canesten Combi-Pak 3-Day Therapy, Canesten Cream, Canesten Solution, Canestine, Chlotrimazole, Clotrimaderm, Clotrimaderm Cream, Clotrimazol, Clotrimazole, Clotrimazolum, Desamix F, Empecid, Fem Care, FemCare, Gyne lotrimin, Gyne-lotrimin, Gyne-Lotrimin 3, Gyne-Lotrimin 3 Combination Pack, Gyne-Lotrimin Combination Pack, Gyne-Lotrimin3, Gyne-Lotrimin3 Combination Pack, Gynix, Lopac-C-6019, Lotrimax, Lotrimin, Lotrimin AF, Lotrimin AF Cream, Lotrimin AF Jock-Itch Cream, Lotrimin AF Lotion, Lotrimin AF Solution, Lotrimin Cream, Lotrimin Lotion, Lotrimin Solution, Lotrisone, Mono-baycuten, Monobaycuten, Mycelax, Mycelex, Mycelex 7, Mycelex Cream, Mycelex G, Mycelex OTC, Mycelex Solution, Mycelex Troches, Mycelex Twin Pack, Mycelex-7, Mycelex-7 Combination Pack, Mycelex-G, Mycelex: MycosporinRimazole, Myclo Cream, Myclo Solution, Myclo Spray Solution, Myclo-Gyne, Mycosporin, Mykosporin, Neo-Zol Cream, Otomax, Pedisafe, Prestwick_120, Rimazole, Tibatin, Trimysten, Trivagizole 3, Veltrim |
| Substituent Name | Aralkylamine, Chlorobenzene, N-substituted imidazole, Aryl halide, Aryl chloride, Heteroaromatic compound, Imidazole, Azole, Azacycle, Organoheterocyclic compound, Hydrocarbon derivative, Organonitrogen compound, Organochloride, Organohalogen compound, Aromatic heteromonocyclic compound |
| Compound Name | Clotrimazole |
| Kingdom | Organic compounds |
| Prediction Hob Swissadme | 0.0 |
| Exact Mass | 344.108 |
| Formal Charge | 0.0 |
| Monoisotopic Mass | 344.108 |
| Hydrogen Bond Acceptor Count | 1.0 |
| Molecular Weight | 344.8 |
| Covalent Unit Count | 1.0 |
| Total Atom Stereocenter Count | 0.0 |
| Total Bond Stereocenter Count | 0.0 |
| Esol | -5.803139 |
| Inchi | InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H |
| Smiles | C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4 |
| Nring | 4.0 |
| Defined Bond Stereocenter Count | 0.0 |
- 1. Outgoing r'ship
FOUND_INto/from Caesalpinia Pulcherrima (Plant) Rel Props:Source_db:cmaup_ingredients