Carbinoxamine
PubChem CID: 2564
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| Compound Synonyms | carbinoxamine, 486-16-8, Paracarbinoxamine, Carbinoxamina, Allergefon, Carbinoxaminum, Paracarinoxamine, Carbinoxamine base, 2-((4-Chlorophenyl)(pyridin-2-yl)methoxy)-N,N-dimethylethanamine, (+-)-Carbinoxamine, McN-R 73Z, Carbinoxaminum [INN-Latin], Carbinoxamina [INN-Spanish], 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine, EINECS 207-628-6, BRN 0250475, CHEBI:3398, Carbinoxamine (INN), UNII-982A7M02H5, (+/-)-carbinoxamine, Carbinoxamine-d6 Maleate Salt, N,N-Dimethyl-2-(p-chloro-alpha-(2-pyridyl)benzyloxy)ethylamine, 982A7M02H5, 2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-N,N-dimethylethanamine, Ethanamine, 2-((4-chlorophenyl)-2-pyridinylmethoxy)-N,N-dimethyl-, Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N,N-dimethyl-, DTXSID4022737, 5-21-03-00492 (Beilstein Handbook Reference), Palgic, Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)-, ( inverted exclamation markA)-Carbinoxamine, {2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]ethyl}dimethylamine maleate, 2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-N,N-dimethylethanamine, CARBINOXAMINE [INN], Carbinoxaminum (INN-Latin), Carbinoxamina (INN-Spanish), Carbinoxamine [INN:BAN], 2-(p-Chloro-.alpha.-(2-(dimethylamino)ethoxy)benzyl)pyridine, Carbinoxamine, McN-R 73Z, Paracarbinoxamine, Paracarinoxamine, {2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]ethyl}dimethylamine, {2-[(4-Chloro-phenyl)-pyridin-2-yl-methoxy]-ethyl}-dimethyl-amine, NCGC00166141-01, Carbinoxamin, (2-((4-Chloro-phenyl)-pyridin-2-yl-methoxy)-ethyl)-dimethyl-amine, Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N,N-dimethyl-, (-)-, ()-Carbinoxamine, Rondec (Salt/Mix), Clistin (Salt/Mix), Ziriton (Salt/Mix), 2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-N,N-dimethylethanamine maleate, {2-[(4-Chlorophenyl)-2-pyridylmethoxy]ethyl}dimethylamine, Spectrum_000100, Prestwick0_000801, Prestwick1_000801, Prestwick2_000801, Prestwick3_000801, Spectrum2_001127, Spectrum3_000327, Spectrum4_000264, Spectrum5_000700, CARBINOXAMINE [MI], (.+/-.)-Carbinoxamine, CHEMBL864, SCHEMBL5070, Oprea1_764868, BSPBio_000661, BSPBio_001933, CARBINOXAMINE [VANDF], KBioGR_000728, KBioSS_000520, DivK1c_000819, SPBio_000993, SPBio_002582, 2-[(4-Chlorophenyl)(2-pyridinyl)methoxy]-N,N-dimethylethanamine #, CARBINOXAMINE [WHO-DD], BPBio1_000729, DTXCID302737, GTPL7139, BDBM81464, KBio1_000819, KBio2_000520, KBio2_003088, KBio2_005656, KBio3_001153, Carbinoxamine maleate (Salt/Mix), R06AA08, NINDS_000819, 2-[(4-chlorophenyl)-(2-pyridyl)methoxy]-N,N-dimethyl-ethanamine, ALBB-023749, HY-B1589, NSC_2564, 2-{[(4-chlorophenyl)(pyridin-2-yl)methyl]oxy}-N,N-dimethylethanamine, AKOS003334261, AKOS016843886, AC-5507, DB00748, SB82406, IDI1_000819, NCGC00166141-02, NCGC00166141-03, NCGC00166141-04, CAS_486-16-8, SBI-0051304.P003, AB00053430, CS-0013488, NS00009224, C06871, D07617, EN300-755282, AB00053430_12, L000924, Q3728177, BRD-A29426959-050-05-8, BRD-A29426959-050-07-4, BRD-A29426959-050-13-2, 2-[(4-chlorophenyl)-pyridin-2-yl-methoxy]-N,N-dimethyl-ethanamine, Pyridine, 2-[p-chloro-.alpha.-[2-(dimethylamino)ethoxy]benzyl]-, 2-[(4-chlorophenyl)-(2-pyridyl)methoxy]ethyl-dimethyl-amine, fumaric acid, 207-628-6 |
|---|---|
| Topological Polar Surface Area | 25.4 |
| Hydrogen Bond Donor Count | 0.0 |
| Inchi Key | OJFSXZCBGQGRNV-UHFFFAOYSA-N |
| Rotatable Bond Count | 6.0 |
| Heavy Atom Count | 20.0 |
| Compound Name | Carbinoxamine |
| Description | Carbinoxamine, also known as carbinoxamine maleate or clistin, is a member of the class of compounds known as benzylethers. Benzylethers are aromatic ethers with the general formula ROCR' (R = alkyl, aryl, R'=benzene). Carbinoxamine is practically insoluble (in water) and a very strong basic compound (based on its pKa). Carbinoxamine can be found in barley and garden onion, which makes carbinoxamine a potential biomarker for the consumption of these food products. Carbinoxamine can be found primarily in blood and urine. In humans, carbinoxamine is involved in the carbinoxamine h1-antihistamine action. Carbinoxamine is a non-carcinogenic (not listed by IARC) potentially toxic compound. Carbinoxamine is a drug which is used for symptomatic relief of seasonal and perennial allergic rhinitis and vasomotor rhinitis, as well as allergic conjunctivitis caused by foods and inhaled allergens. also for the relief of allergic reactions to blood or plasma, and the symptomatic management of mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Carbinoxamine (Clistin, Palgic, Rondec, Rhinopront) is a antihistamine and anticholinergic agent. It was first launched in the United States by the McNeil Corporation under the brand name Clistin. It is now available under the brand name Palgic as 4 mg tablets or 4 mg/5 mL liquid. It is approved by the U.S. Food and Drug Administration (FDA) (specifically at the 4 mg dose/strength) for hay fever (a.k.a. allergic rhinitis, SAR and PAR), vasomotor rhinitis, mild urticaria, angioedema, dermatographism and allergic conjunctivitis. Carbinoxamine is a histamine antagonist, specifically an H1-antagonist. The maleic acid salt of the levorotatory isomer is sold as the prescription drug rotoxamine . Carbinoxamine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Carbinoxamine's anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown (DrugBank). Carbinoxamine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Carbinoxamine's anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown (T3DB). |
| Exact Mass | 290.119 |
| Formal Charge | 0.0 |
| Monoisotopic Mass | 290.119 |
| Isotope Atom Count | 0.0 |
| Molecular Complexity | 267.0 |
| Hydrogen Bond Acceptor Count | 3.0 |
| Molecular Weight | 290.79 |
| Database Name | fooddb_chem_all;pubchem |
| Covalent Unit Count | 1.0 |
| Defined Atom Stereocenter Count | 0.0 |
| Iupac Name | 2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-N,N-dimethylethanamine |
| Total Atom Stereocenter Count | 1.0 |
| Total Bond Stereocenter Count | 0.0 |
| Inchi | InChI=1S/C16H19ClN2O/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13/h3-10,16H,11-12H2,1-2H3 |
| Smiles | CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2 |
| Xlogp | 2.9 |
| Defined Bond Stereocenter Count | 0.0 |
| Molecular Formula | C16H19ClN2O |
- 1. Outgoing r'ship
FOUND_INto/from Allium Cepa (Plant) Rel Props:Source_db:fooddb_chem_all - 2. Outgoing r'ship
FOUND_INto/from Hordeum Vulgare (Plant) Rel Props:Source_db:fooddb_chem_all