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2-Demethylcolchicine

PubChem CID: 23757

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Compound Synonyms 2-Demethylcolchicine, 2-Demethyl Colchicine, 102491-80-5, 7336-36-9, O2-Demethylcolchicine, Colchicine, O(2)-demethyl-, 2-O-demethyl colchicine, Alkaloid CC 6, from Colchicum cornigerum, 2-DESMETHYLCOLCHICIN, CHEMBL1080, N-[(7S)-2-hydroxy-1,3,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide, V9U19L3N0J, O(sup 2)-Demethylcolchicine, NSC-180533, COLCHICINE, O(sup 2)-DEMETHYL-, NSC 180533, (-)-2-Demethylcolchicine, UNII-V9U19L3N0J, Colchicine, 3-demethyl- (7CI), ACETAMIDE, N-((7S)-5,6,7,9-TETRAHYDRO-2-HYDROXY-1,3,10-TRIMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL)-, Acetamide, N-(5,6,7,9-tetrahydro-2-hydroxy-1,3,10-trimethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-, Acetamide, N-[(7S)-5,6,7,9-tetrahydro-2-hydroxy-1,3,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-, 2-dimethylcolchicine, Acetamide, N-(5,6,7,9-tetrahydro-2-hydroxy-1,3,10-trimethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S), SCHEMBL2007529, DTXSID90223605, BDBM50157479, NSC180533, AKOS030254275, FD20990, Q27291711, N-(2-Hydroxy-1,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide, Acetamide,6,7,9-tetrahydro-2-hydroxy-1,3,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-, N-((S)-2-Hydroxy-1,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide, N-[(7S)-5,6,7,9-Tetrahydro-2-hydroxy-1,3,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide, O2-Demethylcolchicine, (-)-2-Demethylcolc hicine
Ghose Rule True
Classyfire Kingdom Organic compounds
Topological Polar Surface Area 94.1
Hydrogen Bond Donor Count 2.0
Pfizer 3 75 Rule True
Scaffold Graph Level CC1CCCC2C(CCCC3CCCCC32)C1
Np Classifier Class Phenethylisoquinoline alkaloids
Deep Smiles COcccc-ccCC[C@@H]c7cc%12=O))))NC=O)C))))))cccc6OC)))O))OC
Heavy Atom Count 28.0
Classyfire Class Tropones
Scaffold Graph Node Level OC1CCCC2C(CCCC3CCCCC32)C1
Isotope Atom Count 0.0
Molecular Complexity 724.0
Database Name cmaup_ingredients;imppat_phytochem;npass_chem_all;pubchem
Defined Atom Stereocenter Count 1.0
Uniprot Id Q6B856, Q9BUF5, Q9H4B7, n.a.
Iupac Name N-[(7S)-2-hydroxy-1,3,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Prediction Hob 1.0
Veber Rule True
Classyfire Superclass Hydrocarbon derivatives
Target Id NPT5136
Xlogp 0.5
Gsk 4 400 Rule True
Molecular Formula C21H23NO6
Scaffold Graph Node Bond Level O=c1cccc2c(c1)CCCc1ccccc1-2
Prediction Swissadme 0.0
Inchi Key DPOVAJCRYIUTBD-HNNXBMFYSA-N
Silicos It Class Moderately soluble
Fcsp3 0.3333333333333333
Logs -3.375
Rotatable Bond Count 4.0
Logd 1.292
Synonyms 2-de-me-colchicine, 2-demethyl colchicine, 2-demethylcolchicine
Esol Class Soluble
Functional Groups CC(=O)NC, c=O, cO, cOC
Compound Name 2-Demethylcolchicine
Prediction Hob Swissadme 0.0
Exact Mass 385.153
Formal Charge 0.0
Monoisotopic Mass 385.153
Hydrogen Bond Acceptor Count 6.0
Molecular Weight 385.4
Gi Absorption True
Covalent Unit Count 1.0
Total Atom Stereocenter Count 1.0
Total Bond Stereocenter Count 0.0
Lipinski Rule Of 5 True
Esol -1.0428506285714296
Inchi InChI=1S/C21H23NO6/c1-11(23)22-15-7-5-12-9-18(27-3)20(25)21(28-4)19(12)13-6-8-17(26-2)16(24)10-14(13)15/h6,8-10,15,25H,5,7H2,1-4H3,(H,22,23)/t15-/m0/s1
Smiles CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)O)OC
Nring 3.0
Np Classifier Biosynthetic Pathway Alkaloids
Defined Bond Stereocenter Count 0.0
Egan Rule True
Np Classifier Superclass Tyrosine alkaloids

  • 1. Outgoing r'ship FOUND_IN to/from Centaurea Behen (Plant) Rel Props:Source_db:npass_chem_all
  • 2. Outgoing r'ship FOUND_IN to/from Colchicum Autumnale (Plant) Rel Props:Reference:https://doi.org/10.15482/usda.adc/1239279
  • 3. Outgoing r'ship FOUND_IN to/from Colchicum Luteum (Plant) Rel Props:Reference:ISBN:9788185042145
  • 4. Outgoing r'ship FOUND_IN to/from Delphinium Consolida (Plant) Rel Props:Source_db:npass_chem_all
  • 5. Outgoing r'ship FOUND_IN to/from Gloriosa Superba (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 6. Outgoing r'ship FOUND_IN to/from Pinus Roxburghii (Plant) Rel Props:Source_db:npass_chem_all