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Atenolol

PubChem CID: 2249

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Compound Synonyms atenolol, 29122-68-7, Tenormin, Prenormine, Blokium, Myocord, Normiten, (RS)-Atenolol, Duraatenolol, Betacard, Corotenol, Tenormine, Atehexal, Betablok, Cuxanorm, Juvental, Selobloc, Tenoblock, Antipressan, Atenblock, Farnormin, Internolol, Premorine, Vericordin, Anselol, Atcardil, Atecard, Atendol, Atereal, Evitocor, Hypoten, Ibinolo, Lotenal, Normalol, Prenolol, Stermin, Tenidon, Tenolol, Tenoprin, Tensimin, Vascoten, Wesipin, Alinor, Altol, Atenet, Ateni, Atenil, Aterol, Hipres, Noten, Oraday, Serten, Tredol, Uniloc, Xaten, Apo-Atenolol, Seles beta, Felo-Bits, Lo-ten, Atenolin, Atenomel, Blocotenol, Cardaxen, Cardiopress, Jenatenol, Panapres, Plenacor, Servitenol, Tenobloc, Aircrit, Betasyn, Ormidol, Prinorm, Unibloc, Loten, Atenol acis, Atenol Cophar, Atenol Fecofar, Atenol Heumann, Atenol Nordic, Atenol Quesada, Atenol Gador, Atenol Stada, Atenol-Mepha, Atenol-Wolff, Atenol Atid, Atenol ct, Atenol Genericon, Atenol Tika, Atenol Trom, Atenol von ct, Betatop Ge, Atenol-ratiopharm, Atenol AL, Atenol PB, Atenol GNR, Atenol MSD, Atenol NM Pharma, Atenololum, Scheinpharm Atenol, Atenol 1A pharma, 2-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide, Tenormine [French], (r,s)-atenolol, Atenololum [INN-Latin], ICI 66082, Novaten, Atcard, dl-Atenolol, 2-[4-(2-Hydroxy-3-isopropylaminopropoxy)phenyl]acetamide, ICI 66,082, Tenormin (TN), 2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide, 1-p-Carbamoylmethylphenoxy-3-isopropylamino-2-propanol, 2-(p-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide, ICI-66082, MFCD00057645, 4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzeneacetamide, CCRIS 4196, 60966-51-0, HSDB 6526, UNII-50VV3VW0TI, EINECS 249-451-7, EINECS 262-544-7, 50VV3VW0TI, NSC-757832, BRN 2739235, CHEBI:2904, DTXSID2022628, Benzeneacetamide, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, Benzeneacetamide, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-, C07AB03, 2-(4-(2-Hydroxy-3-isopropylaminopropoxy)phenyl)acetamid, CHEMBL24, duratenol, 2-(4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)acetamide, MLS000069622, DTXCID202628, Acetamide, 2-(p-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)-, TENORETIC COMPONENT ATENOLOL, Atenolol [USAN:USP:INN:BAN:JAN], NSC 757832, SMR000036768, Atenol, 2-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide, Atenololum (INN-Latin), (+/-)-2-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide, Teno-basan, ATENOLOL (MART.), ATENOLOL [MART.], ATENOLOL (USP-RS), ATENOLOL [USP-RS], ATENOLOL (EP MONOGRAPH), ATENOLOL (USP IMPURITY), ATENOLOL [EP MONOGRAPH], ATENOLOL [USP IMPURITY], ATENOLOL (USP MONOGRAPH), ATENOLOL [USP MONOGRAPH], (+/-)-Atenolol, Neatenol, Tensotin, 2-(P-(HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ACETAMIDE, Atenolol (USAN:USP:INN:BAN:JAN), 2-(P-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ACETAMIDE (RACEMATE), SR-01000000159, 1309283-25-7, atenololo, 2-(4-[2-Hydroxy-3-(isopropylamino)propoxy]phenyl)acetamide, Artrenolol, 2-(4-(2-Hydroxy-3-(Isopropylamino)propoxy)phenyl)ethanamide, phenyl)acetamide, 2-(4-(2-hydroxy-3-((propan-2-yl)amino)propoxy)phenyl)acetamide, Atenolol [USAN:BAN:INN:JAN], (y)-Atenolol, Atenalol (RS), Atenolol,(S), (?)-Atenolol, Atenolol (Standard), (A+/-)-Atenolol, Tenoretic (Salt/Mix), Atenolol (JAN/USP), Spectrum_001364, ATENOLOL [HSDB], ATENOLOL [USAN], ATENOLOL [INN], ATENOLOL [JAN], ATENOLOL [MI], ATENOLOL [VANDF], Opera_ID_1283, Spectrum2_001411, Spectrum3_001448, Spectrum4_000435, Spectrum5_001509, ATENOLOL [WHO-DD], ATENOLOL [WHO-IP], A 7655, SCHEMBL4362, Lopac0_000121, Oprea1_448775, BSPBio_002915, GTPL548, KBioGR_000790, KBioSS_001844, Atenolol - Bio-X trade mark, MLS001066372, MLS001074163, MLS001304038, DivK1c_000057, SPECTRUM1501127, Atenolol (JP18/USP/INN), SPBio_001482, ATENOLOL [ORANGE BOOK], BDBM25753, HMS500C19, KBio1_000057, KBio2_001844, KBio2_004412, KBio2_006980, KBio3_002415, METKIMKYRPQLGS-UHFFFAOYSA-, 4-[2'-Hydroxy-3'-(isopropylamino)propoxy]phenylacetamide, C07AB11, Atenolol, 1mg/ml in Acetonitrile, ATENOLOLUM [WHO-IP LATIN], NINDS_000057, 2-{4-[2-Hydroxy-3-(isopropylamino)propoxy]-phenyl}acetamide, HMS1569L13, HMS1921H09, HMS2090I19, HMS2092D19, HMS2233E06, HMS3259K08, HMS3260I04, HMS3266K13, HMS3369B14, HMS3369D20, HMS3369P20, HMS3411G21, HMS3675G21, HMS3886G03, Pharmakon1600-01501127, ( inverted question mark)-Atenolol, BCP12899, JCC28325, Atenolol 1.0 mg/ml in Acetonitrile, Atenolol, >=98% (TLC), powder, Tox21_302426, Tox21_500121, (+/-)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide, 2-[4-({2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)phenyl]acetamide, BBL009276, CCG-39010, GEO-03413, HY-17498R, NSC757832, s4817, STK528649, AKOS005111050, ATENOLOL COMPONENT OF TENORETIC, AC-8245, Atenolol, analytical reference material, DB00335, FH18009, KS-5341, LP00121, NC00548, SDCCGSBI-0050109.P004, IDI1_000057, MRF-0000571, NCGC00015007-06, NCGC00015007-07, NCGC00015007-08, NCGC00015007-09, NCGC00015007-10, NCGC00015007-11, NCGC00015007-13, NCGC00015007-24, NCGC00024566-03, NCGC00024566-04, NCGC00024566-05, NCGC00024566-06, NCGC00024566-07, NCGC00255122-01, NCGC00260806-01, BA166036, DA-61290, HY-17498, SBI-0050109.P003, CAS-29122-68-7, DB-072177, DB-079552, DB-214565, A1414, EU-0100121, NS00010385, 2-(4-(2-hydroxy-3-(isopropylamino)propoxy), BIM-0050109.0001, D00235, EN300-119532, O10469, AB00052208-13, AB00052208-15, AB00052208_16, L000116, Q411325, SR-01000000159-2, SR-01000000159-4, SR-01000000159-5, SR-01000000159-8, BRD-A20239487-001-02-5, BRD-A20239487-001-15-7, BRD-A20239487-001-24-9, BRD-A20239487-001-25-6, Atenolol, European Pharmacopoeia (EP) Reference Standard, Z1521553991, 2-(p-(2-Hydroxy-3-(isopropylamino)propoxy)phenylacetamide, Atenolol, United States Pharmacopeia (USP) Reference Standard, (RS)-2-{4-[2-Hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide, 2-(4-((2RS)-2-Hydroxy-3-((1-methylethyl)amino)propyloxy)phenyl)acetamide, 2-(4-{[(2S)-2-hydroxy-3-(propan-2-ylamino)propyl]oxy}phenyl)acetamide, Atenolol, Pharmaceutical Secondary Standard, Certified Reference Material, 2-[4-({(2R)-2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)phenyl]acetamide, 106020-65-9, 249-451-7, 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxyl]benzeneacetamide, 2-[p-[2-Hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide, (RS)-ateno lol, Atenolol, InChI=1/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)
Topological Polar Surface Area 84.6
Hydrogen Bond Donor Count 3.0
Heavy Atom Count 19.0
Description Atenolol is a so-called beta1-selective (or 'cardioselective') drug. That means that it exerts greater blocking activity on myocardial beta1-receptors than on beta2 ones in the lung. The beta2 receptors are responsible to keep the bronchial system open. If these receptors are blocked, bronchospasm with serious lack of oxygen in the body can result. However, due to its cardioselective properties, the risk of bronchospastic reactions if using atenolol is reduced compared to nonselective drugs as propranolol. Nonetheless, this reaction may also be encountered with atenolol, particularly with high doses. Extreme caution should be exerted if atenolol is given to asthma patients, who are particularly at risk, the dose should be as low as possible. If an asthma attack occurs, the inhalation of a beta2-mimetic antiasthmatic, such as hexoprenalin or salbutamol, will usually suppress the symptoms., Atenolol (trade name Tenormin) can be used to treat cardiovascular diseases such as hypertension, coronary heart disease, arrhythmias, and treatment of myocardial infarction after the acute event. Patients with compensated congestive heart failure may be treated with atenolol as a co medication (usually together with an ACE inhibitor, a diuretic and a digitalis-glycoside, if indicated). In patients with congestive heart failure, it reduces the need for and the consumption of oxygen of the heart muscle. It is very important to start with low doses, as atenolol reduces also the muscular power of the heart, which is an undesired effect in congestive heart failure. [HMDB]
Isotope Atom Count 0.0
Molecular Complexity 263.0
Database Name cmaup_ingredients;fooddb_chem_all;npass_chem_all;pubchem
Defined Atom Stereocenter Count 0.0
Enzyme Uniprot Id P08588
Uniprot Id P02768, P13945, P18090, P54833, P26255, B0FL73, Q8K4Z4, P07550, P19327, P08588, O15245, P02692, P02545, Q9NUW8, n.a., P21728, O15648, Q13951, Q9UNA4, P49798, O75496, O94956, Q9NPD5, Q9Y6L6, L8I2E6, Q13148, P35368, P08183, O95342, Q92887, O15438, O15439, P0DTD1, P10275
Iupac Name 2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
Prediction Hob 1.0
Class Benzene and substituted derivatives
Target Id NPT225, NPT483, NPT50, NPT226
Xlogp 0.2
Superclass Benzenoids
Subclass Phenylacetamides
Molecular Formula C14H22N2O3
Prediction Swissadme 1.0
Inchi Key METKIMKYRPQLGS-UHFFFAOYSA-N
Fcsp3 0.5
Logs -1.137
Rotatable Bond Count 8.0
State Solid
Logd 0.072
Synonyms 1-P-Carbamoylmethylphenoxy-3-isopropylamino-2-propanol, 2-(P-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide, 4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzeneacetamide, Aircrit, Alinor, Altol, Anselol, Antipressan, Apo-Atenolol, Atcardil, Atecard, Atehexal, Atenblock, Atendol, Atenet, Ateni, Atenil, Atenol 1A pharma, Atenol acis, Atenol AL, Atenol Atid, Atenol Cophar, Atenol ct, Atenol Fecofar, Atenol Gador, Atenol Genericon, Atenol GNR, Atenol Heumann, Atenol MSD, Atenol NM Pharma, Atenol Nordic, Atenol PB, Atenol Quesada, Atenol Stada, Atenol Tika, Atenol Trom, Atenol von ct, Atenol-Mepha, Atenol-ratiopharm, Atenol-Wolff, Atenolin, Atenolol (JAN/USP), Atenolol [USAN:BAN:INN:JAN], Atenololum, Atenololum [INN-Latin], Atenomel, Atereal, Aterol, Betablok, Betacard, Betasyn, Betatop Ge, Blocotenol, Blokium, Cardaxen, Cardiopress, Corotenol, Cuxanorm, Duraatenolol, duratenol, Evitocor, Farnormin, Felo-Bits, Hipres, Hypoten, Ibinolo, Internolol, Jenatenol, Juvental, Lo-ten, Loten, Lotenal, Myocord, Normalol, Normiten, Noten, Oraday, Ormidol, Panapres, Plenacor, Premorine, Prenolol, Prenormine, Prinorm, Scheinpharm Atenol, Seles beta, Selobloc, Serten, Servitenol, Stermin, Tenidon, Tenobloc, Tenoblock, Tenolol, Tenoprin, Tenoretic, Tenormin, Tenormin (TN), Tenormine, Tenormine [French], Tensimin, Tredol, Unibloc, Uniloc, Vascoten, Vericordin, Wesipin, Xaten
Substituent Name Phenylacetamide, Phenol ether, Aralkylamine, Alkyl aryl ether, Secondary alcohol, Primary carboxylic acid amide, Carboxamide group, 1,2-aminoalcohol, Secondary amine, Ether, Secondary aliphatic amine, Carboxylic acid derivative, Carboxylic acid amide, Hydrocarbon derivative, Organooxygen compound, Organonitrogen compound, Carbonyl group, Amine, Alcohol, Aromatic homomonocyclic compound
Compound Name Atenolol
Kingdom Organic compounds
Prediction Hob Swissadme 1.0
Exact Mass 266.163
Formal Charge 0.0
Monoisotopic Mass 266.163
Hydrogen Bond Acceptor Count 4.0
Molecular Weight 266.34
Covalent Unit Count 1.0
Total Atom Stereocenter Count 1.0
Total Bond Stereocenter Count 0.0
Esol -1.7639984105263156
Inchi InChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)
Smiles CC(C)NCC(COC1=CC=C(C=C1)CC(=O)N)O
Nring 1.0
Defined Bond Stereocenter Count 0.0

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