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Withanone

PubChem CID: 21679027

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Compound Synonyms withanone, 27570-38-3, NSC-179884, UNII-GY036XA633, (1S,2S,4S,5R,10R,11S,14S,15S,18S)-15-[(1R)-1-[(2R)-4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-5,15-dihydroxy-10,14-dimethyl-3-oxapentacyclo[9.7.0.02,4.05,10.014,18]octadec-7-en-9-one, GY036XA633, 6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide, (22R)-5alpha,17alpha-Dihydroxy-6alpha,7alpha, compound 11 [PMID: 30776236], (5alpha,6alpha,7alpha,22R)-5,17-Dihydroxy-6,7:22,26-diepoxyergosta-2,24-diene-1,26-dione, compound 11 (PMID: 30776236), (5.ALPHA.,6.ALPHA.,7.ALPHA.,22R)-5,17-DIHYDROXY-6,7:22,26-DIEPOXYERGOSTA-2,24-DIENE-1,26-DIONE, DTXSID40950237, Withanone(sh), (1S,2S,4S,5R,10R,11S,14S,15S,18S)-15-((1R)-1-((2R)-4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl)ethyl)-5,15-dihydroxy-10,14-dimethyl-3-oxapentacyclo(9.7.0.02,4.05,10.014,18)octadec-7-en-9-one, Withanone (Standard), Withanone, analytical standard, CHEMBL516703, SCHEMBL2234025, GTPL13098, CHEBI:231685, 15-[1-(4,5-Dimethyl-6-oxo-2,3-dihydropyran-2-yl)ethyl]-5,15-dihydroxy-10,14-dimethyl-3-oxapentacyclo[9.7.0.02,4.05,10.014,18]octadec-7-en-9-one, CBA57038, BDBM50599324, EX-A11175, AKOS040762509, HY-129692R, DA-68707, MS-28706, HY-129692, CS-0107490, WITHANONE (CONSTITUENT OF ASHWAGANDHA ROOT), Q27279346, (22R)-5alpha,17alpha-Dihydroxy-6alpha,7alpha:22,26-diepoxyergosta-2,24-diene-1,26-dione
Ghose Rule False
Classyfire Kingdom Organic compounds
Topological Polar Surface Area 96.4
Hydrogen Bond Donor Count 2.0
Pfizer 3 75 Rule False
Scaffold Graph Level CC1CCCC(CC2CCC3C2CCC2C4C(C)CCCC4C4CC4C32)C1
Np Classifier Class Ergostane steroids
Deep Smiles CC=CC)C=O)O[C@H]C6)[C@H][C@@]O)CC[C@@H][C@]5C)CC[C@H][C@H]6[C@@H]O[C@@H]3[C@@][C@]7C)C=O)C=CC6)))))O))))))))))))))C
Heavy Atom Count 34.0
Classyfire Class Steroids and steroid derivatives
Scaffold Graph Node Level OC1CCCC(CC2CCC3C2CCC2C4C(O)CCCC4C4OC4C32)O1
Classyfire Subclass Steroid lactones
Isotope Atom Count 0.0
Molecular Complexity 1030.0
Database Name cmaup_ingredients;imppat_phytochem;npass_chem_all;pubchem
Defined Atom Stereocenter Count 11.0
Iupac Name (1S,2S,4S,5R,10R,11S,14S,15S,18S)-15-[(1R)-1-[(2R)-4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-5,15-dihydroxy-10,14-dimethyl-3-oxapentacyclo[9.7.0.02,4.05,10.014,18]octadec-7-en-9-one
Prediction Hob 0.0
Veber Rule True
Classyfire Superclass Lipids and lipid-like molecules
Xlogp 3.1
Gsk 4 400 Rule False
Molecular Formula C28H38O6
Scaffold Graph Node Bond Level O=C1C=CCC(CC2CCC3C2CCC2C4C(=O)C=CCC4C4OC4C32)O1
Prediction Swissadme 1.0
Inchi Key FAZIYUIDUNHZRG-PCTWTJKKSA-N
Silicos It Class Soluble
Fcsp3 0.7857142857142857
Rotatable Bond Count 2.0
Synonyms 5α,17α-dihydroxy-1-oxo-6α,7α-epoxy-22r-witha-2,24-dienolide (withanone), withanone
Esol Class Moderately soluble
Functional Groups CC1=C(C)C(=O)OCC1, CC=CC(C)=O, CO, C[C@@H]1O[C@@H]1C
Compound Name Withanone
Prediction Hob Swissadme 0.0
Exact Mass 470.267
Formal Charge 0.0
Monoisotopic Mass 470.267
Hydrogen Bond Acceptor Count 6.0
Molecular Weight 470.6
Gi Absorption True
Covalent Unit Count 1.0
Total Atom Stereocenter Count 11.0
Total Bond Stereocenter Count 0.0
Lipinski Rule Of 5 True
Esol -4.547257200000002
Inchi InChI=1S/C28H38O6/c1-14-13-19(33-24(30)15(14)2)16(3)27(31)12-9-17-21-18(8-11-25(17,27)4)26(5)20(29)7-6-10-28(26,32)23-22(21)34-23/h6-7,16-19,21-23,31-32H,8-13H2,1-5H3/t16-,17+,18+,19-,21+,22+,23+,25+,26+,27+,28+/m1/s1
Smiles CC1=C(C(=O)O[C@H](C1)[C@@H](C)[C@]2(CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3[C@H]5[C@H](O5)[C@@]6([C@@]4(C(=O)C=CC6)C)O)C)O)C
Np Classifier Biosynthetic Pathway Terpenoids
Defined Bond Stereocenter Count 0.0
Egan Rule True
Np Classifier Superclass Steroids

  • 1. Outgoing r'ship FOUND_IN to/from Physalis Philadelphica (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 2. Outgoing r'ship FOUND_IN to/from Withania Coagulans (Plant) Rel Props:Reference:ISBN:9788172361150
  • 3. Outgoing r'ship FOUND_IN to/from Withania Somnifera (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all