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dimethyl (2R,6R,13R,22S,23S,24S,35R,38R,39S)-13,24-diethyl-23,32-dihydroxy-30,31-dimethoxy-21-oxa-1,9,17,28-tetrazaundecacyclo[22.13.1.16,9.02,22.03,20.05,18.06,16.027,35.029,34.035,38.013,39]nonatriaconta-3,5(18),11,15,19,26,29,31,33-nonaene-15,26-dicarboxylate

PubChem CID: 16663648

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Compound Synonyms CHEMBL220132
Ghose Rule False
Classyfire Kingdom Organic compounds
Topological Polar Surface Area 151.0
Hydrogen Bond Donor Count 4.0
Pfizer 3 75 Rule False
Scaffold Graph Level C1CCC2C(C1)CC1CCC3CC4CC5CC6CC7CCC8CCCC9CCC7(C6CC5C4C4CCC12C34)C89
Np Classifier Class Aspidosperma type
Deep Smiles COC=O)C=CNcc[C@]5[C@@H][C@@]C9)CC))[C@H]O)[C@H]Occ[C@H]5N9CC%12))))cccc6)NC=CC[C@][C@H][C@@]96CCN5CC=C9))))))))CC))))C=O)OC)))))))))))))))))cccc6OC)))OC)))O
Heavy Atom Count 57.0
Classyfire Class Aspidospermatan-type alkaloids
Scaffold Graph Node Level C1CCC2C(C1)NC1CCC3CC4OC5CC6NC7CCC8CCCN9CCC7(C6CC5C4N4CCC12C34)C89
Isotope Atom Count 0.0
Molecular Complexity 1850.0
Database Name cmaup_ingredients;imppat_phytochem;npass_chem_all;pubchem
Defined Atom Stereocenter Count 9.0
Uniprot Id n.a.
Iupac Name dimethyl (2R,6R,13R,22S,23S,24S,35R,38R,39S)-13,24-diethyl-23,32-dihydroxy-30,31-dimethoxy-21-oxa-1,9,17,28-tetrazaundecacyclo[22.13.1.16,9.02,22.03,20.05,18.06,16.027,35.029,34.035,38.013,39]nonatriaconta-3,5(18),11,15,19,26,29,31,33-nonaene-15,26-dicarboxylate
Prediction Hob 0.0
Veber Rule False
Classyfire Superclass Alkaloids and derivatives
Xlogp 4.5
Gsk 4 400 Rule False
Molecular Formula C44H50N4O9
Scaffold Graph Node Bond Level C1=CC2CC=C3Nc4cc5c(cc4C34CCN(C1)C24)C1C(CC2CC=C3Nc4ccccc4C34CCN1C24)O5
Prediction Swissadme 0.0
Inchi Key XVLKCTCGGIJHCK-BFENJZFZSA-N
Silicos It Class Poorly soluble
Fcsp3 0.5454545454545454
Logs -2.857
Rotatable Bond Count 8.0
Logd 2.758
Synonyms conophyllidine
Esol Class Poorly soluble
Functional Groups CC=CC, CN(C)C, CO, cNC(C)=C(C)C(=O)OC, cO, cOC
Compound Name dimethyl (2R,6R,13R,22S,23S,24S,35R,38R,39S)-13,24-diethyl-23,32-dihydroxy-30,31-dimethoxy-21-oxa-1,9,17,28-tetrazaundecacyclo[22.13.1.16,9.02,22.03,20.05,18.06,16.027,35.029,34.035,38.013,39]nonatriaconta-3,5(18),11,15,19,26,29,31,33-nonaene-15,26-dicarboxylate
Prediction Hob Swissadme 0.0
Exact Mass 778.358
Formal Charge 0.0
Monoisotopic Mass 778.358
Hydrogen Bond Acceptor Count 13.0
Molecular Weight 778.9
Gi Absorption False
Covalent Unit Count 1.0
Total Atom Stereocenter Count 9.0
Total Bond Stereocenter Count 0.0
Lipinski Rule Of 5 False
Esol -7.150888073684213
Inchi InChI=1S/C44H50N4O9/c1-7-41-10-9-13-47-14-11-43(39(41)47)24-16-21-28(18-26(24)45-34(43)22(19-41)37(51)55-5)57-33-30(21)48-15-12-44-25-17-27(49)31(53-3)32(54-4)29(25)46-35(44)23(38(52)56-6)20-42(8-2,36(33)50)40(44)48/h9-10,16-18,30,33,36,39-40,45-46,49-50H,7-8,11-15,19-20H2,1-6H3/t30-,33+,36-,39+,40+,41+,42-,43+,44+/m1/s1
Smiles CC[C@]12CC(=C3[C@@]4([C@H]1N(CC4)CC=C2)C5=C(N3)C=C6C(=C5)[C@@H]7[C@H](O6)[C@H]([C@]8(CC(=C9[C@@]1([C@H]8N7CC1)C1=CC(=C(C(=C1N9)OC)OC)O)C(=O)OC)CC)O)C(=O)OC
Nring 11.0
Np Classifier Biosynthetic Pathway Alkaloids
Defined Bond Stereocenter Count 0.0
Egan Rule False
Np Classifier Superclass Tryptophan alkaloids