Naproxen
PubChem CID: 156391
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| Compound Synonyms | NAPROXEN, 22204-53-1, (S)-Naproxen, Naprosyn, Naproxene, (+)-Naproxen, Equiproxen, (S)-2-(6-methoxynaphthalen-2-yl)propanoic acid, Aleve, Naproxeno, (S)-(+)-Naproxen, d-Naproxen, Ec-Naprosyn, (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid, (+)-(S)-Naproxen, Laraflex, Naprosyne, Naproxenum, Nycopren, Calosen, Naixan, Reuxen, Bonyl, Axer, (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid, Novonaprox, Acusprain, Anexopen, Apronax, Artagen, Arthrisil, Artrixen, Artroxen, Atiflan, Bipronyl, Clinosyn, Danaprox, Flexipen, Genoxen, Lefaine, Leniartil, Nafasol, Nalyxan, Napflam, Naposin, Naprius, Veradol, Congex, Daprox, Fuxen, Napmel, Napren, Naxen, Naxyn, Xenar, Dysmenalgit N, Apo-Naproxen, naproxen(+), Floginax, Napratec, Naprontag, Naxopren, Pronaxen, Rheumaflex, Saritilron, Sinartrin, Soproxen, Anaprox, Flexen, Headlon, Napxen, Narocin, Noflam, Patxen, Prafena, Priaxen, Rahsen, Sinton, Sutolin, Sutony, Tohexen, Traumox, Velsay, Vinsen, Narma, Naxid, Roxen, Anax, Flanax Forte, Naprosyn LLE, Napren E, Proxen LE, Naxen F, Proxen LLE, U-Ritis, RS-3540, (S)-2-(6-Methoxy-2-naphthyl)propionic acid, (+)-2-(6-Methoxy-2-naphthyl)propionic acid, Naprosyn LLE Forte, Naproxi 250, Naproxi 500, (+)-2-(Methoxy-2-naphthyl)-propionic acid, (S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid, Naxyn 250, Naxyn 500, Xenar-CR, (S)-2-(6-Methoxy-2-naphthyl)propanoic acid, d-2-(6-Methoxy-2-naphthyl)propionic acid, (+)-2-(Methoxy-2-naphthyl)-propionsaeure, CCRIS 5265, CHEBI:7476, Diocodal, Naprolag, Naprosine, Naprosy, Prexan, CG 3117, Apo-Napro-NA, (+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid, HSDB 3369, Naproxene [INN-French], Naproxenum [INN-Latin], Naproxeno [INN-Spanish], EINECS 244-838-7, UNII-57Y76R9ATQ, Dysmenalgit, NSC-750183, NSC-757239, Proxen, RS 3540, 57Y76R9ATQ, DTXSID4040686, PN400 COMPONENT NAPROXEN, (alphas)-6-methoxy-alpha-methyl-2-naphthaleneacetic acid, d-2-(6'-Methoxy-2'-naphthyl)-propionsaeure, MFCD00010500, CHEMBL154, (+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid, Propionic acid, 2-(6-methoxy-2-naphthyl)-, (+)-, (S)-(+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid, 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, (+)-, 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, (S)-, Duk, VIMOVO COMPONENT NAPROXEN, DTXCID2020686, Methoxypropiocin, (2S)-2-(6-methoxy-2-naphthyl)propanoic acid, EC 244-838-7, Apranax, Naprium, Naprux, Naproxen [USAN:USP:INN:BAN:JAN], NSC 750183, NSC 757239, 2-Naphthaleneacetic acid, 6-methoxy-.alpha.-methyl-, (S)-, Naproxene (INN-French), Naproxenum (INN-Latin), 2-Naphthaleneacetic acid, 6-methoxy-.alpha.-methyl-, (.alpha.S)-, CAS-22204-53-1, Naproxeno (INN-Spanish), NAPROXEN (MART.), NAPROXEN [MART.], NAPROXEN (USP-RS), NAPROXEN [USP-RS], (S)-2-(6-Methoxy-naphthalen-2-yl)-propionic acid, NAPROXEN (EP MONOGRAPH), NAPROXEN [EP MONOGRAPH], (S)-6-Methoxy-.alpha.-methyl-2-naphthaleneacetic acid, NAPROXEN (USP MONOGRAPH), NAPROXEN [USP MONOGRAPH], Equiproxen (Veterinary), Naproxen (USAN:USP:INN:BAN:JAN), S-NAPROXEN, Panoxen, Proxine, (S)-6-Methoxy-alpha-methyl-2-naphthaleneacetate, Mnpa, Naproxen oral, SR-01000075977, DL Naproxen, Equiproxen Granules, Naprosyn (TN), Naproxen,(S), NPS, Prestwick_349, (+)-2-(Methoxy-2-naphthyl)-propionsaeure [German], Naproxen (Standard), d-2-(6'-Methoxy-2'-naphthyl)-propionsaeure [German], Naproxendelayed release, EC-NAPROXEN, 6-methoxy-alpha-methyl-2-naphthaleneacetic acid, Spectrum_000977, (R)-6-Methoxy-a-methyl-2-naphthaleneacetic acid, 4or0, 4po0, NAPROXEN [HSDB], NAPROXEN [USAN], (S)-(+)-Naproxene, NAPROXEN [INN], NAPROXEN [JAN], Naproxen Delayed Release, Naproxen Oral Suspension, NAPROXEN [MI], NAPROXEN [VANDF], Prestwick0_000791, Prestwick1_000791, Prestwick2_000791, Spectrum2_001043, Spectrum3_000514, Spectrum4_000069, Spectrum5_001327, (+)NAPROXEN, Equiproxen 10% Solution, Naproxen2-(6-Methoxy-naphthalen-2-yl)-propionic acid, Epitope ID:139974, NAPROXEN [WHO-DD], UPCMLD-DP001, 2-(6-Methoxy-naphthalen-2-yl)-propionic acid(Naproxen), SCHEMBL3046, Lopac0_000792, BSPBio_002067, KBioGR_000597, KBioSS_001457, BIDD:GT0062, DivK1c_000242, NAPROXEN [GREEN BOOK], SPECTRUM1500425, Naproxen (JP17/USP/INN), Naproxen, 1mg/ml in Methanol, SPBio_000966, SPBio_002861, NAPROXEN [ORANGE BOOK], GTPL5230, UPCMLD-DP001:001, CMWTZPSULFXXJA-VIFPVBQESA-, HMS500M04, KBio1_000242, KBio2_001457, KBio2_004025, KBio2_006593, KBio3_001567, G02CC02, M01AE02, M02AA12, Naproxen 1.0 mg/ml in Methanol, NINDS_000242, HMS1920P13, HMS2089N21, HMS2091H12, HMS3649M13, HMS3886C15, Pharmakon1600-01500425, NAPROXEN COMPONENT OF VIMOVO, Tox21_301953, BDBM50339185, CCG-40130, HY-15030R, NSC750183, NSC757239, AKOS005267223, AC-1363, DB00788, FN26157, ME-0100, SDCCGSBI-0050769.P005, IDI1_000242, Naproxen 100 microg/mL in Acetonitrile, NCGC00016759-01, NCGC00016759-02, NCGC00016759-03, NCGC00016759-29, NCGC00016759-38, NCGC00021127-01, NCGC00161591-01, NCGC00255562-01, HY-15030, (+)-2-(Methoxy-2-naphthyl)-propionsaure, Naproxen, meets USP testing specifications, SBI-0050769.P004, Sallus Pain Relief Collection With Naproxen, M1021, NS00098611, S5177, Naproxen, VETRANAL(TM), analytical standard, (S)-2-(6-methoxy-2-naphthyl)-propionic acid, (S)-2-(6-methoxynaphthalen-2-yl)propanoicacid, C01517, d-2-(6'-methoxy-2'-naphthyl)-propionic acid, D00118, EN300-139795, O10203, (2S)-2-(6-methoxy(2-naphthyl))propanoic acid, AB00052049-04, AB00052049_05, ()-2-(METHOXY-2-NAPHTHYL)-PROPIONIC ACID, ()-2-(METHOXY-2-NAPHTHYL)-PROPIONSAEURE, (+)(S)2-(6-methoxy-2-naphthyl)-propionic acid, 2-(6-Methoxy-2-naphthyl)propanoic acid , (+)-, SR-01000003110, Q1215575, SR-01000003110-5, SR-01000075977-3, SR-01000075977-4, (+)-6-Methoxy-.alpha.-methyl-2-napthaleneacetic acid, BRD-K59197931-001-02-9, BRD-K59197931-001-03-7, BRD-K59197931-001-04-5, BRD-K59197931-236-09-6, BRD-K59197931-236-20-3, BRD-K59197931-236-21-1, BRD-K59197931-236-22-9, SR-01000075977-10, (+)-6-Methoxy-.alpha.-methyl-2-naphthaleneacetic acid, (S)-(+)-2-(6-methoxy-naphthalen-2-yl)-propionic acid, (S)-6-Methoxy-.alpha.-methyl-2-naphthalene acetic acid, (S)-6-Methoxy-?-methyl-2-naphthaleneacetic acid, Aproxen, 2-naphthaleneacetic acid, 6-methoxy-alpha-methyl, (S)-, 2-naphthleneacetic acid, 6-methoxy-alpha-methyl-, (+)-, Naproxen, British Pharmacopoeia (BP) Reference Standard, Naproxen, European Pharmacopoeia (EP) Reference Standard, PROPIONIC ACID, 2-(METHOXY-2-NAPHTHYL)-, ()-, Z1695772815, (S)-(+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid, 98%, 2-Naphthaleneacetic acid, 6-methoxy-.alpha.-methyl-, (+)-, Naproxen, United States Pharmacopeia (USP) Reference Standard, (+)-(S)-6-METHOXY-.ALPHA.-METHYL-2-NAPHTHALENEACETIC ACID, Naproxen, Pharmaceutical Secondary Standard, Certified Reference Material, (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic Acid, (S)-(+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic Acid, 131991-52-1, 244-838-7, InChI=1/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1 |
|---|---|
| Topological Polar Surface Area | 46.5 |
| Hydrogen Bond Donor Count | 1.0 |
| Heavy Atom Count | 17.0 |
| Description | Naproxen (INN) is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the reduction of mild to moderate pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, injury (like fractures), menstrual cramps, tendonitis, bursitis, and the treatment of primary dysmenorrhea. Naproxen and naproxen sodium are marketed under various trade names including: Aleve, Anaprox, Naprogesic, Naprosyn, Naprelan, Naproxen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the reduction of mild to moderate pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, injury (like fractures), menstrual cramps, tendonitis, bursitis, and the treatment of primary dysmenorrhea. Naproxen and naproxen sodium are marketed under various trade names including: Aleve, Anaprox, Naprogesic, Naprosyn, Naprelan. Naproxen was first marketed as the prescription drug Naprosyn in 1976 and naproxen sodium was first marketed under the trade name Anaprox in 1980. It remains a prescription-only drug in much of the world. The U.S. Food and Drug Administration (FDA) approved the use of naproxen sodium as an over-the-counter (OTC) drug in 1991, where OTC preparations are sold under the trade name Aleve. In Australia, small packets of lower-strength preparations of naproxen sodium are Schedule 2 Pharmacy Medicines, Naproxen is a member of the 2-arylpropionic acid (profen) family of NSAIDs. It is an odorless, white to off-white crystalline substance. It is lipid-soluble, practically insoluble in water with a low pH (below pH 4), while freely soluble in water at 6 pH and above. Naproxen has a melting point of 153 degree centigrade. [HMDB] |
| Isotope Atom Count | 0.0 |
| Molecular Complexity | 277.0 |
| Database Name | cmaup_ingredients;fooddb_chem_all;npass_chem_all;pubchem |
| Defined Atom Stereocenter Count | 1.0 |
| Uniprot Id | P02768, P13945, P12527, Q63921, O09114, n.a., P05979, P35354, P23219, P25024, Q05769, P42330, P49810, O62664, P79208, Q92887, P15304, P16473, O15648, P83916, P05177, P16662, P22309, P35503, P22310, Q9HAW9, O60656, P36537, P06133, O35913, P46720, Q4U2R8, O35956, P52895, P17516, Q04828, P08170, Q9Y6L6, Q9NPD5, P15289, P27695, Q8NER1, P51589, P35747, O95342, O15438, O15439, P08684, P10635, P11712, P0DTD1, P00374, Q8TDX5, P10275 |
| Iupac Name | (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid |
| Prediction Hob | 1.0 |
| Class | Naphthalenes |
| Target Id | NPT31, NPT30, NPT3504, NPT210, NPT208, NPT665, NPT3507, NPT2818 |
| Xlogp | 3.3 |
| Superclass | Benzenoids |
| Molecular Formula | C14H14O3 |
| Prediction Swissadme | 0.0 |
| Inchi Key | CMWTZPSULFXXJA-VIFPVBQESA-N |
| Fcsp3 | 0.2142857142857142 |
| Logs | -3.851 |
| Rotatable Bond Count | 3.0 |
| State | Solid |
| Logd | 3.372 |
| Synonyms | (+)-(S)-6-Methoxy-a-methyl-2-naphthaleneacetate, (+)-(S)-6-Methoxy-a-methyl-2-naphthaleneacetic acid, (+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetate, (+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid, (+)-(S)-6-Methoxy-α-methyl-2-naphthaleneacetate, (+)-(S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid, (+)-(S)-Naproxen, (+)-2-(6-Methoxy-2-naphthyl)propionate, (+)-2-(6-Methoxy-2-naphthyl)propionic acid, (+)-2-(Methoxy-2-naphthyl)-propionate, (+)-2-(Methoxy-2-naphthyl)-propionic acid, (+)-2-(Methoxy-2-naphthyl)-propionsaeure, (+)-Naproxen, (S)-(+)-2-(6-Methoxy-2-naphthyl)propionate, (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid, (S)-(+)-Naproxen, (S)-2-(6-Methoxy-2-naphthyl)propanoate, (S)-2-(6-Methoxy-2-naphthyl)propanoic acid, (S)-2-(6-Methoxy-2-naphthyl)propionate, (S)-2-(6-Methoxy-2-naphthyl)propionic acid, (S)-6-Methoxy-a-methyl-2-naphthaleneacetate, (S)-6-Methoxy-a-methyl-2-naphthaleneacetic acid, (S)-6-Methoxy-alpha-methyl-2-naphthaleneacetate, (S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid, (S)-6-Methoxy-α-methyl-2-naphthaleneacetate, (S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid, (S)-Naproxen, 2-(6-Methoxy-2-naphthyl)propionic acid, Acusprain, Anexopen, Apronax, Artagen, Arthrisil, Artrixen, Artroxen, Atiflan, Axer, Bipronyl, Calosen, Clinosyn, Congex, d-Naproxen, Danaprox, Daprox, Diocodal, DL Naproxen, DL-Naproxen, Duk, Dysmenalgit, Dysmenalgit N, Ec-Naprosyn, Equiproxen, Flexipen, Floginax, Fuxen, Genoxen, Lefaine, Leniartil, Nafasol, Naixan, Nalyxan, Napflam, Napmel, Naposin, Naprosyne, Naproxen, Naproxen Sodium, Naproxene, Naproxeno, Naproxenum, Novonaprox, Nycopren, Opipramol |
| Substituent Name | Naphthalene, Anisole, Alkyl aryl ether, Monocarboxylic acid or derivatives, Ether, Carboxylic acid, Carboxylic acid derivative, Hydrocarbon derivative, Organooxygen compound, Carbonyl group, Aromatic homopolycyclic compound |
| Compound Name | Naproxen |
| Kingdom | Organic compounds |
| Prediction Hob Swissadme | 0.0 |
| Exact Mass | 230.094 |
| Formal Charge | 0.0 |
| Monoisotopic Mass | 230.094 |
| Hydrogen Bond Acceptor Count | 3.0 |
| Molecular Weight | 230.26 |
| Covalent Unit Count | 1.0 |
| Total Atom Stereocenter Count | 1.0 |
| Total Bond Stereocenter Count | 0.0 |
| Esol | -3.6091247176470587 |
| Inchi | InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1 |
| Smiles | C[C@@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O |
| Nring | 2.0 |
| Defined Bond Stereocenter Count | 0.0 |
- 1. Outgoing r'ship
FOUND_INto/from Plantago Major (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all