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Conophylline

PubChem CID: 15226696

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Compound Synonyms Cophylline, Conophylline, 142741-24-0, dimethyl (2R,6R,11R,13S,14S,23S,24S,25S,36R,39R,40R)-14,25-diethyl-24,33-dihydroxy-31,32-dimethoxy-12,22-dioxa-1,9,18,29-tetrazadodecacyclo[23.13.1.16,9.02,23.03,21.05,19.06,17.011,13.028,36.030,35.036,39.014,40]tetraconta-3,5(19),16,20,27,30,32,34-octaene-16,27-dicarboxylate, 16,27-Dimethyl 14,25-diethyl-24,33-dihydroxy-31,32-dimethoxy-12,22-dioxa-1,9,18,29-tetraazadodecacyclo(23.13.1.1,.0,.0,.0,.0,.0,.0,.0,.0,.0,)tetraconta-3(21),4,16,19,27,30,32,34-octaene-16,27-dicarboxylic acid, 16,27-Dimethyl 14,25-diethyl-24,33-dihydroxy-31,32-dimethoxy-12,22-dioxa-1,9,18,29-tetraazadodecacyclo[23.13.1.1,.0,.0,.0,.0,.0,.0,.0,.0,.0,]tetraconta-3(21),4,16,19,27,30,32,34-octaene-16,27-dicarboxylic acid, dimethyl (2R,6R,11R,13S,14S,23S,24S,25S,36R,39R,40R)-14,25-diethyl-24,33-dihydroxy-31,32-dimethoxy-12,22-dioxa-1,9,18,29-tetrazadodecacyclo(23.13.1.16,9.02,23.03,21.05,19.06,17.011,13.028,36.030,35.036,39.014,40)tetraconta-3,5(19),16,20,27,30,32,34-octaene-16,27-dicarboxylate, CHEMBL506768, AKOS032962004
Ghose Rule False
Classyfire Kingdom Organic compounds
Topological Polar Surface Area 164.0
Hydrogen Bond Donor Count 4.0
Pfizer 3 75 Rule False
Scaffold Graph Level C1CCC2C(C1)CC1CCC3CC4CC5CC6CC7CCC8C9CC9CC9CCC7(C6CC5C4C4CCC12C34)C98
Np Classifier Class Aspidosperma type
Deep Smiles COC=O)C=CNcc[C@]5[C@@H][C@@]C9)CC))[C@H]O)[C@H]Occ[C@H]5N9CC%12))))cccc6)NC=CC[C@][C@H][C@@]96CCN5C[C@@H][C@H]9O3)))))))))CC))))C=O)OC)))))))))))))))))cccc6OC)))OC)))O
Heavy Atom Count 58.0
Classyfire Class Aspidospermatan-type alkaloids
Scaffold Graph Node Level C1CCC2C(C1)NC1CCC3CC4OC5CC6NC7CCC8C9OC9CN9CCC7(C6CC5C4N4CCC12C34)C89
Isotope Atom Count 0.0
Molecular Complexity 1890.0
Database Name cmaup_ingredients;imppat_phytochem;npass_chem_all;pubchem
Defined Atom Stereocenter Count 11.0
Uniprot Id n.a.
Iupac Name dimethyl (2R,6R,11R,13S,14S,23S,24S,25S,36R,39R,40R)-14,25-diethyl-24,33-dihydroxy-31,32-dimethoxy-12,22-dioxa-1,9,18,29-tetrazadodecacyclo[23.13.1.16,9.02,23.03,21.05,19.06,17.011,13.028,36.030,35.036,39.014,40]tetraconta-3,5(19),16,20,27,30,32,34-octaene-16,27-dicarboxylate
Prediction Hob 0.0
Veber Rule False
Classyfire Superclass Alkaloids and derivatives
Xlogp 3.7
Gsk 4 400 Rule False
Molecular Formula C44H50N4O10
Scaffold Graph Node Bond Level C1=C2Nc3cc4c(cc3C23CCN2CC5OC5C(C1)C23)C1C(CC2CC=C3Nc5ccccc5C35CCN1C25)O4
Prediction Swissadme 0.0
Inchi Key QZRIMAMDGWAHPQ-ATPAGDLWSA-N
Silicos It Class Poorly soluble
Fcsp3 0.5909090909090909
Logs -2.992
Rotatable Bond Count 8.0
Logd 2.674
Synonyms conophylline
Esol Class Poorly soluble
Functional Groups CN(C)C, CO, C[C@H]1O[C@H]1C, cNC(C)=C(C)C(=O)OC, cO, cOC
Compound Name Conophylline
Prediction Hob Swissadme 0.0
Exact Mass 794.353
Formal Charge 0.0
Monoisotopic Mass 794.353
Hydrogen Bond Acceptor Count 14.0
Molecular Weight 794.9
Gi Absorption False
Covalent Unit Count 1.0
Total Atom Stereocenter Count 11.0
Total Bond Stereocenter Count 0.0
Lipinski Rule Of 5 False
Esol -6.7181958482758635
Inchi InChI=1S/C44H50N4O10/c1-7-41-16-20(37(51)55-5)34-44(23-14-25(49)30(53-3)31(54-4)28(23)46-34)10-12-48(40(41)44)29-19-13-22-24(15-26(19)57-32(29)35(41)50)45-33-21(38(52)56-6)17-42(8-2)36-27(58-36)18-47-11-9-43(22,33)39(42)47/h13-15,27,29,32,35-36,39-40,45-46,49-50H,7-12,16-18H2,1-6H3/t27-,29-,32+,35-,36-,39+,40+,41-,42-,43+,44+/m1/s1
Smiles CC[C@]12CC(=C3[C@@]4([C@H]1N(CC4)[C@H]5[C@@H]([C@H]2O)OC6=CC7=C(C=C56)[C@]89CCN1[C@H]8[C@](CC(=C9N7)C(=O)OC)([C@H]2[C@@H](C1)O2)CC)C1=CC(=C(C(=C1N3)OC)OC)O)C(=O)OC
Nring 12.0
Np Classifier Biosynthetic Pathway Alkaloids
Defined Bond Stereocenter Count 0.0
Egan Rule False
Np Classifier Superclass Tryptophan alkaloids

  • 1. Outgoing r'ship FOUND_IN to/from Tabernaemontana Corymbosa (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 2. Outgoing r'ship FOUND_IN to/from Tabernaemontana Divaricata (Plant) Rel Props:Reference:ISBN:9788172361150; ISBN:9788172362300; ISBN:9788185042145