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Somniferine

PubChem CID: 14106343

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Compound Synonyms Somniferine, 117611-63-9, (4R,4aS,7aR,12bS)-6-[(2S,4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-2-yl]-4a,9-dihydroxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one, CHEBI:191570, (4R,4aS,7aR,12bS)-6-[(2S,4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzouro[3,2-e]isoquinolin-2-yl]-4a,9-dihydroxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzouro[3,2-e]isoquinolin-7-one
Ghose Rule False
Classyfire Kingdom Organic compounds
Topological Polar Surface Area 101.0
Hydrogen Bond Donor Count 2.0
Pfizer 3 75 Rule True
Scaffold Graph Level CC1C(C2CC3CC4CCCC5CC6CCCC3C6(C2)C45)CC2C3CCCC24C1CC1CCCC(C3)C14
Np Classifier Class Morphinan alkaloids
Deep Smiles COC=CC=C[C@][C@H]6Occ5cC[C@H]9N[C@@H]C%11)C=C[C@@]O)[C@H]Ccc[C@]6[C@H]C%10=O))Oc5cO)cc9))))))CCN8C)))))))))))))C))))ccc6OC
Heavy Atom Count 45.0
Classyfire Class Morphinans
Description Alkaloid from Papaver somniferum (opium poppy)
Scaffold Graph Node Level OC1C(C2CC34C5CCCC3C(CC3CCCC(O5)C34)N2)CC2C3CC4CCCC5OC1C2(CCN3)C45
Isotope Atom Count 0.0
Molecular Complexity 1440.0
Database Name fooddb_chem_all;hmdb_chem_all;imppat_phytochem;pubchem
Defined Atom Stereocenter Count 8.0
Iupac Name (4R,4aS,7aR,12bS)-6-[(2S,4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-2-yl]-4a,9-dihydroxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Class Morphinans
Veber Rule True
Classyfire Superclass Alkaloids and derivatives
Xlogp 2.6
Superclass Alkaloids and derivatives
Gsk 4 400 Rule False
Molecular Formula C36H36N2O7
Scaffold Graph Node Bond Level O=C1C(C2CC34C5=CC=CC3Oc3cccc(c34)CC5N2)=CC2C3Cc4cccc5c4C2(CCN3)C1O5
Inchi Key JQGBUIZIHWUPHT-CSVNJIPGSA-N
Silicos It Class Poorly soluble
Rotatable Bond Count 3.0
Synonyms somniferine, somniferine+
Esol Class Moderately soluble
Functional Groups CC=C(C)C(C)=O, CN(C)C, CO, COC1=CC=C(C)CC1, cO, cOC
Compound Name Somniferine
Kingdom Organic compounds
Exact Mass 608.252
Formal Charge 0.0
Monoisotopic Mass 608.252
Hydrogen Bond Acceptor Count 9.0
Molecular Weight 608.7
Gi Absorption True
Covalent Unit Count 1.0
Total Atom Stereocenter Count 8.0
Total Bond Stereocenter Count 0.0
Molecular Framework Aromatic heteropolycyclic compounds
Lipinski Rule Of 5 True
Inchi InChI=1S/C36H36N2O7/c1-37-12-11-35-28-18-5-8-23(39)30(28)44-33(35)29(40)19(15-36(35,41)26(37)14-18)22-16-34-20-7-10-25(43-4)32(34)45-31-24(42-3)9-6-17(27(31)34)13-21(20)38(22)2/h5-10,15,21-22,26,32-33,39,41H,11-14,16H2,1-4H3/t21-,22+,26-,32+,33+,34+,35+,36-/m1/s1
Smiles CN1CC[C@]23[C@@H]4C(=O)C(=C[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O)[C@@H]6C[C@]78[C@@H]9C(=CC=C7[C@H](N6C)CC1=C8C(=C(C=C1)OC)O9)OC
Np Classifier Biosynthetic Pathway Alkaloids
Defined Bond Stereocenter Count 0.0
Egan Rule True
Taxonomy Direct Parent Morphinans
Np Classifier Superclass Tyrosine alkaloids

  • 1. Outgoing r'ship FOUND_IN to/from Papaver Somniferum (Plant) Rel Props:Reference:https://doi.org/10.2174/0929867033456729
  • 2. Outgoing r'ship FOUND_IN to/from Withania Somnifera (Plant) Rel Props:Reference:ISBN:9780387706375; ISBN:9788171360536; ISBN:9789327275590