Lormetazepam
PubChem CID: 13314
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| Compound Synonyms | Lormetazepam, Methyllorazepam, N-Methyllorazepam, Loramet, Noctamid, 848-75-9, Lormetazepamum, Chlorotemazepam, Ergocalm, Noctamide, Loramet (TN), WY-4082, Ro 5-5516, 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one, Lormetazepamum [INN-Latin], 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one, Dormagen, WY 4082, 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one, Lormetazepam [USAN:INN:BAN:JAN], ()-Lorazepam, EINECS 212-700-5, BRN 0759821, GU56C842ZA, 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-, CHEBI:52993, 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3H-1,4-benzodiazepin-2-one, LORMETAZEPAM [MI], LORMETAZEPAM [INN], LORMETAZEPAM [JAN], LORMETAZEPAM [USAN], LORMETAZEPAM [MART.], CHEMBL22097, LORMETAZEPAM [WHO-DD], 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-, DTXSID40862442, Lormetazepamum (INN-Latin), 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one, LORMETAZEPAM (MART.), 7-Chloro-1,3-dihydro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one, Lormetazepam (1.0mg/ml in Acetonitrile), (RS)-Lormetazepam, (+/-)-Lormetazepam, UNII-GU56C842ZA, Loretam, DEA No. 2774, (+-)-Lorazepam, SCHEMBL43267, GTPL7553, Lormetazepam (JAN/USAN/INN), DTXCID10811205, N05CD06, Lormetazepam 0.1 mg/ml in Methanol, Lormetazepam 1.0 mg/ml in Methanol, Lormetazepam, 1mg/ml in Acetonitrile, DB13872, FL24939, ZK-65997, NS00010067, D01657, Q186257, 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one #, 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1h-1,4-benzodiazepin-2(3h)-one, 212-700-5 |
|---|---|
| Topological Polar Surface Area | 52.9 |
| Hydrogen Bond Donor Count | 1.0 |
| Heavy Atom Count | 22.0 |
| Description | Lormetazepam, also known as methyllorazepam or (+-)-lorazepam, is a member of the class of compounds known as 1,4-benzodiazepines. 1,4-benzodiazepines are organic compounds containing a benzene ring fused to a 1,4-azepine. Lormetazepam is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Lormetazepam can be found in potato, which makes lormetazepam a potential biomarker for the consumption of this food product. Lormetazepam is a non-carcinogenic (not listed by IARC) potentially toxic compound. Lormetazepam is a drug which is used for the treatment of short-term insomnia [l927. The Dutch, British, and French system called the System of Objectified Judgement Analysis for assessing whether drugs should be included in drug formularies based on clinical efficacy, adverse effects, pharmacokinetic properties, toxicity, and drug interactions was used to assess lormetazepam. A Dutch analysis using the system found that lormetazepam could be suitable to be included in drug prescribing formularies, although zolpidem, zopiclone, and temazepam had higher scores and thus can be seen as relatively favorable . The primary manifestation of overdosage ranges from drowsiness to coma and symptoms may include ataxia, hypotension, hypotonia, respiratory depression which may lead to death [L927]. |
| Isotope Atom Count | 0.0 |
| Molecular Complexity | 471.0 |
| Database Name | fooddb_chem_all;hmdb_chem_all;pubchem |
| Defined Atom Stereocenter Count | 0.0 |
| Iupac Name | 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3H-1,4-benzodiazepin-2-one |
| Nih Violation | False |
| Class | Benzodiazepines |
| Xlogp | 2.4 |
| Superclass | Organoheterocyclic compounds |
| Is Pains | False |
| Subclass | 1,4-benzodiazepines |
| Molecular Formula | C16H12Cl2N2O2 |
| Inchi Key | FJIKWRGCXUCUIG-UHFFFAOYSA-N |
| Rotatable Bond Count | 1.0 |
| State | Solid |
| Synonyms | (+-)-lorazepam, Ergocalm, Loramet, Loramet (TN), Lorazepam, Loretam, Lormetazepam (jan/usan/inn), Lormetazepam [usan:inn:ban:jan], Lormetazepamum, Methyllorazepam, N-methyllorazepam, Noctamid, O-chlorooxazepam, O-chloroxazepam, (+-)-Lorazepam, 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one, 7-Chloro-5-(O-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one, N-Methyllorazepam, O-Chlorooxazepam, O-Chloroxazepam, ()-Lorazepam, 7-chloro-5-(2-Chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one, Noctamide |
| Compound Name | Lormetazepam |
| Kingdom | Organic compounds |
| Exact Mass | 334.028 |
| Formal Charge | 0.0 |
| Brenk Violation | False |
| Monoisotopic Mass | 334.028 |
| Hydrogen Bond Acceptor Count | 3.0 |
| Molecular Weight | 335.2 |
| Covalent Unit Count | 1.0 |
| Total Atom Stereocenter Count | 1.0 |
| Total Bond Stereocenter Count | 0.0 |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Inchi | InChI=1S/C16H12Cl2N2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3 |
| Smiles | CN1C2=C(C=C(C=C2)Cl)C(=NC(C1=O)O)C3=CC=CC=C3Cl |
| Defined Bond Stereocenter Count | 0.0 |
| Taxonomy Direct Parent | 1,4-benzodiazepines |
- 1. Outgoing r'ship
FOUND_INto/from Solanum Tuberosum (Plant) Rel Props:Source_db:fooddb_chem_all