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9-Methoxycamptothecin

PubChem CID: 123617

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Compound Synonyms 9-Methoxycamptothecin, 39026-92-1, 9-Methoxycamptothecine, Camptothecin, 9-methoxy-, NSC176323, NSC-176323, (19S)-19-ethyl-19-hydroxy-8-methoxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione, (S)-4-ethyl-4-hydroxy-10-methoxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione, NSC 176323, CAMPTOTHECIN,9-METHOXY, CHEMBL522112, SCHEMBL1004508, DTXSID00192292, CHEBI:228847, XVMZDZFTCKLZTF-NRFANRHFSA-N, HY-N6011, MFCD03840473, ZB1864, AKOS037514539, NCGC00385478-01, DA-60631, MS-26164, NCI60_001450, PD125185, CS-0032150, F17695, (19S)-19-ethyl-19-hydroxy-8-methoxy-17-oxa-3,13-diazapentacyclo[11.8.0.0(2),(1)(1).0?,?.0(1)?,(2)?]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione, (4S)-4-Ethyl-4-hydroxy-10-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (ACI), 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-methoxy-, (S)- (ZCI), 9-Methoxycamptothecin, 9-Methoxycamptothecine, NSC 176323, (S)-4-ethyl-4-hydroxy-10-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, {1H-Pyrano[3',} {4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-,} 4-ethyl-4-hydroxy-10-methoxy-, (S)-, 1H-Pyrano[3',7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-, 4-ethyl-4-hydroxy-10-methoxy-, (S)-, NCGC00385478-01_C21H18N2O5_1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-methoxy-, (4S)-
Ghose Rule True
Classyfire Kingdom Organic compounds
Topological Polar Surface Area 89.0
Hydrogen Bond Donor Count 1.0
Pfizer 3 75 Rule True
Scaffold Graph Level CC1CCC2C(C1)CC1C3CC4CCCCC4CC3CC1C2C
Np Classifier Class Pyrroloquinoline alkaloids
Deep Smiles CC[C@@]O)C=O)OCcc6cc-cncccccc6cc%10Cn%13c%17=O)))))))OC
Heavy Atom Count 28.0
Classyfire Class Camptothecins
Scaffold Graph Node Level OC1CC2CC3C4NC5CCCCC5CC4CN3C(O)C2CO1
Isotope Atom Count 0.0
Molecular Complexity 790.0
Database Name cmaup_ingredients;imppat_phytochem;npass_chem_all;pubchem
Defined Atom Stereocenter Count 1.0
Iupac Name (19S)-19-ethyl-19-hydroxy-8-methoxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
Prediction Hob 1.0
Veber Rule True
Classyfire Superclass Alkaloids and derivatives
Xlogp 1.0
Gsk 4 400 Rule True
Molecular Formula C21H18N2O5
Scaffold Graph Node Bond Level O=C1Cc2cc3n(c(=O)c2CO1)Cc1cc2ccccc2nc1-3
Prediction Swissadme 1.0
Inchi Key XVMZDZFTCKLZTF-NRFANRHFSA-N
Silicos It Class Moderately soluble
Fcsp3 0.2857142857142857
Logs -4.761
Rotatable Bond Count 2.0
Logd 1.635
Synonyms 9-methoxy camptothecin, 9-methoxycamptothecin, camptothecin, 9-methoxy
Esol Class Soluble
Functional Groups CO, COC(C)=O, c=O, cOC, cn(c)C, cnc
Compound Name 9-Methoxycamptothecin
Prediction Hob Swissadme 1.0
Exact Mass 378.122
Formal Charge 0.0
Monoisotopic Mass 378.122
Hydrogen Bond Acceptor Count 6.0
Molecular Weight 378.4
Gi Absorption True
Covalent Unit Count 1.0
Total Atom Stereocenter Count 1.0
Total Bond Stereocenter Count 0.0
Lipinski Rule Of 5 True
Esol -4.146337942857143
Inchi InChI=1S/C21H18N2O5/c1-3-21(26)14-8-16-18-11(7-12-15(22-18)5-4-6-17(12)27-2)9-23(16)19(24)13(14)10-28-20(21)25/h4-8,26H,3,9-10H2,1-2H3/t21-/m0/s1
Smiles CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5OC)N=C4C3=C2)O
Nring 5.0
Np Classifier Biosynthetic Pathway Alkaloids
Defined Bond Stereocenter Count 0.0
Egan Rule True
Np Classifier Superclass Tryptophan alkaloids

  • 1. Outgoing r'ship FOUND_IN to/from Aristolochia Triangularis (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 2. Outgoing r'ship FOUND_IN to/from Camptotheca Acuminata (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 3. Outgoing r'ship FOUND_IN to/from Ervatamia Heyneana (Plant) Rel Props:Source_db:npass_chem_all
  • 4. Outgoing r'ship FOUND_IN to/from Nothapodytes Nimmoniana (Plant) Rel Props:Reference:ISBN:9770972795006; ISBN:9788185042114
  • 5. Outgoing r'ship FOUND_IN to/from Ophiorrhiza Mungos (Plant) Rel Props:Reference:ISBN:9770972795006
  • 6. Outgoing r'ship FOUND_IN to/from Ophiorrhiza Rugosa (Plant) Rel Props:Reference:ISBN:9770972795006
  • 7. Outgoing r'ship FOUND_IN to/from Tabernaemontana Alternifolia (Plant) Rel Props:Reference:ISBN:9770972795006