Glycylglycine
PubChem CID: 11163
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| Compound Synonyms | Glycylglycine, 556-50-3, Diglycine, Gly-Gly, N-GLYCYLGLYCINE, Glycyl-glycine, Glycine, glycyl-, 2-(2-Aminoacetamido)Acetic Acid, Glycine dipeptide, Glycyl Glycine, Glycine, N-glycyl-, 2-[(2-aminoacetyl)amino]acetic acid, H-Gly-Gly-OH, 2-(Aminoacetamido)acetic acid, Gly2, Gly-Gly-OH, alpha-Glycylglycine, Dipeptide-15, Diglycine (VAN), [(Aminoacetyl)amino]acetic acid, MFCD00008130, CHEBI:17201, EINECS 209-127-8, NSC 49346, NSC-49346, GLYCYLGLYCINE [MI], DIGLYCINE [USP-RS], AI3-62521, CHEMBL292467, ((aminoacetyl)amino)acetic acid, 10525P22U0, DTXSID90862194, [(ammonioacetyl)amino]acetate, 2-(2-azanylethanoylamino)ethanoic acid, DIGLYCINE (USP-RS), GLYGLY, N Glycylglycine, 2-((2-azaniumylacetyl)amino)acetate, 2-[(2-azaniumylacetyl)amino]acetate, 2-((2-aminoacetyl)amino)acetic acid, Glycylgycine, glycine, glycyl, alphaGlycylglycine, Glycine, Nglycyl, UNII-10525P22U0, GG0, H-Gly-Gly, Glycylglycine, DL-, .alpha.-Glycylglycine, n-GLYCYL- Glycine, Glycylglycine (Standard), Glycylglycine, Free Base, Gly-Gly, 98%, 2(Aminoacetamido)acetic acid, SCHEMBL14934, DIPEPTIDE-15 [INCI], 2-(2-Aminoacetamido)AceticAcid, HY-D0889R, DTXCID80197700, Gly-Gly, >=99% (titration), [(Aminoacetyl)amino]acetic acid #, HY-D0889, NSC49346, BBL018705, BDBM50169222, s4810, STL194277, AKOS001045997, 3-Azapentanoic acid, 5-amino-4-oxo-, CCG-231053, FG40134, 2-(glycylamino)acetic acid, hydrochloride, Gly-Gly, BioXtra, >=99.0% (NT), AS-14771, BP-31104, Gly-Gly, BioUltra, >=99.5% (NT), SY018005, Gly-Gly, Vetec(TM) reagent grade, 99%, DB-002742, CS-0015211, G0124, NS00013721, EN300-34095, C02037, F17229, Q665455, Glycyl-glycine, N-Glycylglycine, Diglycine, Gly-Gly, F2191-0195, 33903968-DDB2-47F2-9B6C-7C232D1962DA, Dyglycine, United States Pharmacopeia (USP) Reference Standard, Gly-Gly, BioPerformance Certified, cell culture tested, >=99%, 2-[(2-Aminoacetyl)amino]acetic Acid (Diglycine, N-Glycylglycine), 209-127-8 |
|---|---|
| Ghose Rule | False |
| Classyfire Kingdom | Organic compounds |
| Topological Polar Surface Area | 92.4 |
| Hydrogen Bond Donor Count | 3.0 |
| Pfizer 3 75 Rule | True |
| Np Classifier Class | Dipeptides |
| Deep Smiles | NCC=O)NCC=O)O |
| Heavy Atom Count | 9.0 |
| Classyfire Class | Carboxylic acids and derivatives |
| Description | The simplest peptide, made of two glycine molecules, used in the synthesis of more complicated peptides. Glycine is a simple, nonessential amino acid, although experimental animals show reduced growth on low-glycine diets. The average adult ingests 3 to 5 grams of glycine daily. Glycine is involved in the body's production of DNA, phospholipids and collagen, and in release of energy. Glycine levels are effectively measured in plasma in both normal patients and those with inborn errors of glycine metabolism. (http://www.dcnutrition.com/AminoAcids/) Nonketotic hyperglycinaemia (OMIM 606899) is an autosomal recessive condition caused by deficient enzyme activity of the glycine cleavage enzyme system (EC 2.1.1.10). The glycine cleavage enzyme system comprises four proteins: P-, T-, H- and L-proteins (EC 1.4.4.2, EC 2.1.2.10 and EC 1.8.1.4 for P-, T- and L-proteins). Mutations have been described in the GLDC (OMIM 238300), AMT (OMIM 238310), and GCSH (OMIM 238330) genes encoding the P-, T-, and H-proteins respectively. The glycine cleavage system catalyses the oxidative conversion of glycine into carbon dioxide and ammonia, with the remaining one-carbon unit transferred to folate as methylenetetrahydrofolate. It is the main catabolic pathway for glycine and it also contributes to one-carbon metabolism. Patients with a deficiency of this enzyme system have increased glycine in plasma, urine and cerebrospinal fluid (CSF) with an increased CSF: plasma glycine ratio. (PMID 16151895) [HMDB] |
| Classyfire Subclass | Amino acids, peptides, and analogues |
| Isotope Atom Count | 0.0 |
| Molecular Complexity | 123.0 |
| Database Name | fooddb_chem_all;hmdb_chem_all;imppat_phytochem;pubchem |
| Defined Atom Stereocenter Count | 0.0 |
| Iupac Name | 2-[(2-aminoacetyl)amino]acetic acid |
| Class | Carboxylic acids and derivatives |
| Veber Rule | True |
| Classyfire Superclass | Organic acids and derivatives |
| Xlogp | -2.9 |
| Superclass | Organic acids and derivatives |
| Subclass | Amino acids, peptides, and analogues |
| Gsk 4 400 Rule | True |
| Molecular Formula | C4H8N2O3 |
| Inchi Key | YMAWOPBAYDPSLA-UHFFFAOYSA-N |
| Silicos It Class | Soluble |
| Rotatable Bond Count | 3.0 |
| State | Solid |
| Synonyms | ((aminoacetyl)amino)acetic acid, [(Aminoacetyl)amino]acetate, [(aminoacetyl)amino]acetic acid, 2-(Aminoacetamido)acetate, 2-(Aminoacetamido)acetic acid, alpha-glycylglycine, Diglycine, Diglycine (van), Gly-gly, Gly2, Glycine dipeptide, Glycylglycine, n-GLYCYL- Glycine, N-glycylglycine, [(Aminoacetyl)amino]acetic acid, N-Glycylglycine, ((Aminoacetyl)amino)acetic acid, alpha-Glycylglycine, N-GLYCYL- glycine, Glycylglycine hydrochloride, Glycyl glycine, Glycylglycine monohydrochloride, Hydrochloride, glycylglycine, Monohydrochloride, glycylglycine, N Glycylglycine, Glycyl-glycine, glycylglycine |
| Substituent Name | Alpha peptide, N-acyl-aliphatic-alpha amino acid, N-acyl-alpha amino acid or derivatives, N-acyl-alpha-amino acid, Alpha-amino acid amide, Alpha-amino acid or derivatives, N-substituted-alpha-amino acid, Secondary carboxylic acid amide, Carboxamide group, Monocarboxylic acid or derivatives, Carboxylic acid, Carboxylic acid amide, Hydrocarbon derivative, Primary amine, Organooxygen compound, Organonitrogen compound, Primary aliphatic amine, Carbonyl group, Amine, Aliphatic acyclic compound |
| Esol Class | Highly soluble |
| Functional Groups | CC(=O)O, CN, CNC(C)=O |
| Compound Name | Glycylglycine |
| Kingdom | Organic compounds |
| Exact Mass | 132.053 |
| Formal Charge | 0.0 |
| Monoisotopic Mass | 132.053 |
| Hydrogen Bond Acceptor Count | 4.0 |
| Molecular Weight | 132.12 |
| Gi Absorption | True |
| Covalent Unit Count | 1.0 |
| Total Atom Stereocenter Count | 0.0 |
| Total Bond Stereocenter Count | 0.0 |
| Molecular Framework | Aliphatic acyclic compounds |
| Lipinski Rule Of 5 | True |
| Inchi | InChI=1S/C4H8N2O3/c5-1-3(7)6-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9) |
| Smiles | C(C(=O)NCC(=O)O)N |
| Np Classifier Biosynthetic Pathway | Amino acids and Peptides |
| Defined Bond Stereocenter Count | 0.0 |
| Egan Rule | False |
| Taxonomy Direct Parent | Dipeptides |
| Np Classifier Superclass | Small peptides |
- 1. Outgoing r'ship
FOUND_INto/from Blighia Sapida (Plant) Rel Props:Reference:ISBN:9788185042053