Trilaurin
PubChem CID: 10851
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| Compound Synonyms | TRILAURIN, 538-24-9, Glyceryl tridodecanoate, Glycerol trilaurate, Glyceryl trilaurate, Tridodecanoin, Glycerin trilaurate, Lauric acid triglyceride, Trilauroylglycerol, Laurin, tri-, 1,2,3-Tridodecanoylglycerol, Lauric acid triglycerin ester, Tridodecanoyl glycerol, Dynasan 112, Dodecanoic acid, 1,2,3-propanetriyl ester, 2,3-di(dodecanoyloxy)propyl dodecanoate, 7FP2Z3RVUV, NSC 4061, propane-1,2,3-triyl tridodecanoate, Trilauroyl-glycerol, CCRIS 6991, NSC-4061, EINECS 208-687-0, LAURIC TRIGLYCERIDE, GLYCERIN TRIDODECANOATE, 1,2,3-tridodecanoyl-glycerol, Dodecanoic acid, 1,2,3-propantriyl ester, AI3-11124, Dodecanoic acid, 1,1',1''-(1,2,3-propanetriyl) ester, CHEBI:77389, propane-1,2,3-triyl trilaurate, 1,2,3-tridodecanoyl-sn-glycerol, DTXSID80904390, 1,2,3-Propanetriol tridodecanoate, 1,2,3-tridodecanoyl-sn-sn-glycerol, MFCD00026559, Dodecanoic acid 1,2,3-propanetriyl ester, TG(12:0/12:0/12:0), UNII-7FP2Z3RVUV, 1,2,3-Trilauroylglycerol, Tri-laurin, tridodecanoylglycerol, Trilaurin (Standard), Laurin, tri-(8CI), TRILAURIN [INCI], Glyceryl tridodecanoic acid, 1,3-bis(dodecanoyloxy)propan-2-yl dodecanoate, SCHEMBL74325, Glyceryl tridodecanoate, >=99%, NSC4061, DTXCID901333546, TAG 36:0, LMGL03012618, AKOS015903262, Dodecanoic acid,2,3-propanetriyl ester, HY-126573R, 2,3-Bis(dodecanoyloxy)propyl laurate #, Dodecanoic acid, tri-ester with glycerol, DA-58733, FT157452, LS-15419, SY052022, HY-126573, CS-0105651, G0087, NS00014177, Q27146924, Trilaurin, European Pharmacopoeia (EP) Reference Standard |
|---|---|
| Ghose Rule | False |
| Classyfire Kingdom | Organic compounds |
| Topological Polar Surface Area | 78.9 |
| Hydrogen Bond Donor Count | 0.0 |
| Pfizer 3 75 Rule | False |
| Np Classifier Class | Triacylglycerols |
| Deep Smiles | CCCCCCCCCCCC=O)OCCOC=O)CCCCCCCCCCC))))))))))))))COC=O)CCCCCCCCCCC |
| Heavy Atom Count | 45.0 |
| Classyfire Class | Glycerolipids |
| Description | TG(12:0/12:0/12:0) or trilauric glyceride is a tridodecanoic acid triglyceride or medium chain triglyceride. Triglycerides (TGs) are also known as triacylglycerols or triacylglycerides, meaning that they are glycerides in which the glycerol is esterified with three fatty acid groups (i.e. fatty acid tri-esters of glycerol). TGs may be divided into three general types with respect to their acyl substituents. They are simple or monoacid if they contain only one type of fatty acid, diacid if they contain two types of fatty acids and triacid if three different acyl groups. Chain lengths of the fatty acids in naturally occurring triglycerides can be of varying lengths and saturations but 16, 18 and 20 carbons are the most common. TG(12:0/12:0/12:0), in particular, consists of one chain of dodecanoic acid at the C-1 position, one chain of dodecanoic acid at the C-2 position and one chain of dodecanoic acid at the C-3 position. TGs are the main constituent of vegetable oil and animal fats. TGs are major components of very low density lipoprotein (VLDL) and chylomicrons, play an important role in metabolism as energy sources and transporters of dietary fat. They contain more than twice the energy (9 kcal/g) of carbohydrates and proteins. In the intestine, triglycerides are split into glycerol and fatty acids (this process is called lipolysis) with the help of lipases and bile secretions, which can then move into blood vessels. The triglycerides are rebuilt in the blood from their fragments and become constituents of lipoproteins, which deliver the fatty acids to and from fat cells among other functions. Various tissues can release the free fatty acids and take them up as a source of energy. Fat cells can synthesize and store triglycerides. When the body requires fatty acids as an energy source, the hormone glucagon signals the breakdown of the triglycerides by hormone-sensitive lipase to release free fatty acids. As the brain cannot utilize fatty acids as an energy source, the glycerol component of triglycerides can be converted into glucose for brain fuel when it is broken down. (www.cyberlipid.org, www.wikipedia.org) TAGs can serve as fatty acid stores in all cells, but primarily in adipocytes of adipose tissue. The major building block for the synthesis of triacylglycerides, in non-adipose tissue, is glycerol. Adipocytes lack glycerol kinase and so must use another route to TAG synthesis. Specifically, dihydroxyacetone phosphate (DHAP), which is produced during glycolysis, is the precursor for TAG synthesis in adipose tissue. DHAP can also serve as a TAG precursor in non-adipose tissues, but does so to a much lesser extent than glycerol. The use of DHAP for the TAG backbone depends on whether the synthesis of the TAGs occurs in the mitochondria and ER or the ER and the peroxisomes. The ER/mitochondria pathway requires the action of glycerol-3-phosphate dehydrogenase to convert DHAP to glycerol-3-phosphate. Glycerol-3-phosphate acyltransferase then esterifies a fatty acid to glycerol-3-phosphate thereby generating lysophosphatidic acid. The ER/peroxisome reaction pathway uses the peroxisomal enzyme DHAP acyltransferase to acylate DHAP to acyl-DHAP which is then reduced by acyl-DHAP reductase. The fatty acids that are incorporated into TAGs are activated to acyl-CoAs through the action of acyl-CoA synthetases. Two molecules of acyl-CoA are esterified to glycerol-3-phosphate to yield 1,2-diacylglycerol phosphate (also known as phosphatidic acid). The phosphate is then removed by phosphatidic acid phosphatase (PAP1), to generate 1,2-diacylglycerol. This diacylglycerol serves as the substrate for addition of the third fatty acid to make TAG. Intestinal monoacylglycerols, derived from dietary fats, can also serve as substrates for the synthesis of 1,2-diacylglycerols. [HMDB]. Glycerol tridodecanoate is found in sweet bay. |
| Classyfire Subclass | Triradylcglycerols |
| Isotope Atom Count | 0.0 |
| Molecular Complexity | 626.0 |
| Database Name | cmaup_ingredients;fooddb_chem_all;imppat_phytochem;npass_chem_all;pubchem |
| Defined Atom Stereocenter Count | 0.0 |
| Enzyme Uniprot Id | P16233, P11150, P38571, P54315, Q9NST1, P07098, Q9Y5X9, O75907, P54317, Q92523, P50416, P06858, P23786, Q99685, P23141, P07237, Q3SYC2, P41247, Q96PD7, Q96PD6, Q86VF5, Q53EU6, Q96AD5, Q17RR3 |
| Iupac Name | 2,3-di(dodecanoyloxy)propyl dodecanoate |
| Prediction Hob | 0.0 |
| Class | Glycerolipids |
| Veber Rule | False |
| Classyfire Superclass | Lipids and lipid-like molecules |
| Xlogp | 15.4 |
| Superclass | Lipids and lipid-like molecules |
| Subclass | Triradylcglycerols |
| Gsk 4 400 Rule | False |
| Molecular Formula | C39H74O6 |
| Prediction Swissadme | 0.0 |
| Inchi Key | VMPHSYLJUKZBJJ-UHFFFAOYSA-N |
| Silicos It Class | Insoluble |
| Fcsp3 | 0.9230769230769232 |
| Rotatable Bond Count | 38.0 |
| State | Solid |
| Synonyms | 1,2,3-Propanetriol tridodecanoate, 1,2,3-Propanetriyl tridodecanoate, 1,2,3-Tridodecanoylglycerol, 1,2,3-Trilauroylglycerol, 2,3-Bis(dodecanoyloxy)propyl laurate, Dodecanoate 1,2,3-propanetriyl ester, Dodecanoic acid 1,2,3-propanetriyl ester, Dodecanoic acid, 1,1',1''-(1,2,3-propanetriyl) ester, Dodecanoic acid, 1,2,3-propanetriyl ester, Dodecanoic acid, 1,2,3-propantriyl ester, Dodecanoic acid, tri-ester with glycerol, Glycerin trilaate, Glycerin trilaic acid, Glycerin trilaurate, Glycerin trilauric acid, Glycerol trilaate, Glycerol trilaic acid, Glycerol trilaurate, Glycerol trilauric acid, Glyceryl tridodecanoate, Glyceryl tridodecanoic acid, Glyceryl trilaate, Glyceryl trilaic acid, Glyceryl trilaurate, Glyceryl trilauric acid, Laate triglyceride, Laate triglycerin ester, Laic acid triglyceride, Laic acid triglycerin ester, Lauric acid triglyceride, Lauric acid triglycerin ester, Laurin, Laurin, tri-, Propane-1,2,3-triyl trilaate, Propane-1,2,3-triyl trilaic acid, Propane-1,2,3-triyl trilaurate, Propane-1,2,3-triyl trilauric acid, TG 12:0/12:0/12:0, TG(12:0/12:0/12:0), Tri-laurin, Tridodecanoin, Tridodecanoyl glycerol, Tridodecanoylglycerol, Trilaurin, Trilauroylglycerol, trilaurin |
| Substituent Name | Triacyl-sn-glycerol, Tricarboxylic acid or derivatives, Fatty acid ester, Fatty acyl, Carboxylic acid ester, Ether, Carboxylic acid derivative, Hydrocarbon derivative, Organooxygen compound, Carbonyl group, Aliphatic acyclic compound |
| Esol Class | Insoluble |
| Functional Groups | COC(C)=O |
| Compound Name | Trilaurin |
| Kingdom | Organic compounds |
| Prediction Hob Swissadme | 0.0 |
| Exact Mass | 638.549 |
| Formal Charge | 0.0 |
| Monoisotopic Mass | 638.549 |
| Hydrogen Bond Acceptor Count | 6.0 |
| Molecular Weight | 639.0 |
| Gi Absorption | False |
| Covalent Unit Count | 1.0 |
| Total Atom Stereocenter Count | 0.0 |
| Total Bond Stereocenter Count | 0.0 |
| Lipinski Rule Of 5 | False |
| Esol | -11.021093 |
| Inchi | InChI=1S/C39H74O6/c1-4-7-10-13-16-19-22-25-28-31-37(40)43-34-36(45-39(42)33-30-27-24-21-18-15-12-9-6-3)35-44-38(41)32-29-26-23-20-17-14-11-8-5-2/h36H,4-35H2,1-3H3 |
| Smiles | CCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCC)OC(=O)CCCCCCCCCCC |
| Np Classifier Biosynthetic Pathway | Fatty acids |
| Defined Bond Stereocenter Count | 0.0 |
| Egan Rule | False |
| Np Classifier Superclass | Glycerolipids |
- 1. Outgoing r'ship
FOUND_INto/from Aconitum Subcuneatum (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 2. Outgoing r'ship
FOUND_INto/from Castanea Dentata (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 3. Outgoing r'ship
FOUND_INto/from Cinnamomum Glaucescens (Plant) Rel Props:Reference:ISBN:9788172360481 - 4. Outgoing r'ship
FOUND_INto/from Cullen Corylifolium (Plant) Rel Props:Reference:ISBN:9788185042114 - 5. Outgoing r'ship
FOUND_INto/from Elaphoglossum Lindbergii (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 6. Outgoing r'ship
FOUND_INto/from Ferula Ammoniacum (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 7. Outgoing r'ship
FOUND_INto/from Laurus Nobilis (Plant) Rel Props:Source_db:fooddb_chem_all - 8. Outgoing r'ship
FOUND_INto/from Leucocarpus Perfoliatus (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 9. Outgoing r'ship
FOUND_INto/from Litsea Monopetala (Plant) Rel Props:Reference:ISBN:9788172363130 - 10. Outgoing r'ship
FOUND_INto/from Pistacia Atlantica (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 11. Outgoing r'ship
FOUND_INto/from Rapanea Neurophylla (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 12. Outgoing r'ship
FOUND_INto/from Rogeria Adenophylla (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 13. Outgoing r'ship
FOUND_INto/from Scrophularia Buergeriana (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 14. Outgoing r'ship
FOUND_INto/from Stemodia Maritima (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 15. Outgoing r'ship
FOUND_INto/from Trifolium Hybridum (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all