Lohasava
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| Storage | Store in a cool place in tightly closed amber coloured bottle; protected from light and moisture. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Physico Chemical | Total phenolic content: 0.062 to 0.075 per cent w/v Appendix 5.1.1 equivalent to tannic acid; Total solids: Not less than 3.0 per cent w/v; Appendix 3.8 Specific gravity (at 250): 1.00 to 1.20; Appendix 3.2 p H: 3.4 to 4.5; Appendix 3.3 Reducing sugars: Not less than 14.0 per cent w/v; Appendix 5.1.3 Non-reducing sugars: Not more than .80 per cent w/v; Appendix 5.1.3 Alcohol content: 4 to 10 per cent v/v; Appendix 3.17 Methanol: Absent; Appendix 2.8 Assay: The sample contains 0.1 to 0.5 per cent w/v of gallic acid and 0.09 to 0.1 per cent w/v of ethyl gallate; when assayed by the following method. Estimation of gallic acid and ethyl gallate: Dissolve 1 mg each of gallic acid and ethyl gallate in 1 ml each of methanol separately. Apply separately 1.0 to 8.0 nl each of (5 data point) of above solutions on TLC plate and develop the plate to a distance of 8 cm using toluene: ethyl acetate: acetic acid (5 : 4 : 1) acid as mobile phase. Derivatise the plate with Natural product reagent and dry in a current of cold air and scan in the TLC scanner at a wavelength of 366 nm. Note the peak areas under curve for the peaks corresponding to gallic acid and ethyl gallate and prepare the calibration curve by plotting peak area vs. concentration of gallic acid and ethyl gallate separately. Process vacuum-dried 50 ml of the formulation under thin layer chromatography. Apply 5 nl of the test solution on TLC plate. Develop; dry and scan the plate as described in preceding paragraph for calibration curve of gallic acid and ethyl gallate. Calculate the amount of gallic acid and ethyl gallate in the test solution from the calibration curves of gallic acid and ethyl gallate respectively. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Description | Clear; dark brown liquid without frothing and significant sedimentation; with astringent taste | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Other Requirements | Microbial limit: Appendix 2.4 Aflatoxins: Appendix 2.7 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Dosage | 15 - 30 ml orally with equal amount of water after meals twice a day. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Anupana | Equal quantity of water | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Definition | Lohasava is a fermented liquid preparation made with the ingredients in the Formulation composition given below. It contains not more than 10 per cent; and not less than 5 per cent of alcohol that is self generated in the preparation over a period of time. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Source | Ayurvedic Standard Treatment Guidelines; Ayurvedic Pharmacopeia of India; Ayurvedic Formulary of India | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Time Of Administration | After meal/twice daily | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ingredients |
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| Duration | 2-3 weeks | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Formulation Name | Lohasava | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Method | Take the raw materials of pharmacopoeial quality. Wash; dry and powder the ingredients numbered 2 to 11 of the formulation composition and pass through the sieve number 44 to obtain coarse powder. Add specified amount of water to the ingredient number 14 of the formulation composition; allow to dissolve and filter through the muslin cloth. Transfer the filtrate to a clean container; add Loha Bhasma; Madhu; Dhataka and coarsely powdered other drugs. Seal the mouth of the container. Shift the container to the fermentation room and constantly check for the signs of completion of fermentation process. Filter the fermented material through a clean muslin cloth. Pack in air tight containers and allow for maturation. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Dosage Form | Asava | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Combined Diseases | Pandu, Jathara, Pandu, Shvayathu, Gulma, Arsa, Agnimandya, Plaha Roga, Kustha, Kasa, Shvasa, Bhagandara, Aruci, Grahana, Hridroga . |
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ASSOCIATED_WITHto/from Skin Diseases(ID:disease_node_6968) (Disease) Rel Props:Source_db:Ayurvedic Standard Treatment Guidelines;Ayurvedic Pharmacopeia of India; Ayurvedic_term:Kustha - 2. Outgoing r'ship
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ASSOCIATED_WITHto/from Heart Diseases(ID:disease_node_3722) (Disease) Rel Props:Source_db:Ayurvedic Standard Treatment Guidelines;Ayurvedic Pharmacopeia of India; Ayurvedic_term:Hridroga - 15. Outgoing r'ship
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IS_INGREDIENT_INto/from Lonicera Hypoleuca (Plant) Rel Props:Matched_synonym:Yellow Himalayan Honeysuckle; Source_db:Ayurvedic Standard Treatment Guidelines; Ayurvedic Pharmacopeia of India; Ayurvedic Formulary of India; Match_type:synonym_contains; Pharmacopoeia_ref:Madhu(-); Quantity:3.072 kg - 9. Incoming r'ship
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IS_INGREDIENT_INto/from Piper Nigrum (Plant) Rel Props:Matched_synonym:Piper nigrum; Source_db:Ayurvedic Standard Treatment Guidelines; Ayurvedic Pharmacopeia of India; Ayurvedic Formulary of India; Match_type:synonym_exact; Pharmacopoeia_ref:Marica(Fruit); Quantity:192 g; Part:Fruit - 16. Incoming r'ship
IS_INGREDIENT_INto/from Ricinus Communis (Plant) Rel Props:Matched_synonym:Ricinus communis; Source_db:Ayurvedic Standard Treatment Guidelines; Ayurvedic Pharmacopeia of India; Ayurvedic Formulary of India; Match_type:synonym_exact; Pharmacopoeia_ref:Eranda(Root); Quantity:192 g; Part:Root - 17. Incoming r'ship
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IS_INGREDIENT_INto/from Woodfordia Fruticosa (Plant) Rel Props:Matched_synonym:Woodfordia fruticosa; Source_db:Ayurvedic Standard Treatment Guidelines; Ayurvedic Pharmacopeia of India; Ayurvedic Formulary of India; Match_type:synonym_exact; Pharmacopoeia_ref:Dhataki(Flower); Quantity:960 g; Part:Flower - 22. Incoming r'ship
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