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Kusmandaka Rasayana

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StorageStore in a cool place in tightly closed containers; protected from light and moisture.
DefinitionKooshmandaka Rasayana is a semisolid avaleha preparation made with the ingredients in the Formulation composition given below.
Ingredients
Ingredient NameScientific NamePharmacopoeia RefIpni IdPartsQuantity
Kooshmandaka APIBenincasa hispidaKusmanda(Fruit)163640-3Fresh Fr.4.8 kg
Ghrta APIClarified butter from cow’s milkNANANA768 g
Khanda APISugar candyNANANA4.8 kg
Pippali APIPiper longumPippali(Fruit)682031-1Fruit96 g
Shrngavera (Shunthi API)Zingiber officinaleSunthi(Rhizome)798372-1Rhizome96 g
Jiraka (Shveta jiraka API)Cuminum cyminumSvetajiraka(Fruit)840882-1Fruit96 g
Tvak APICinnamomum zeylanicumTvak(Bark)1166647-2Stem bark24 g
Ela (Sooksmaila API)Elettaria cardamomumSuksmaila(Fruit)796556-1Seed24 g
Patra (Tejaptra API)Cinnamomum tamalaTvakpatra(Leaf)463718-1Leaf24 g
Marica API.Piper nigrumMarica(Fruit)682369-1Fruit24 g
Dhanya (Dhanyaka API)Coriandrum sativumDhanyaka(Fruit)840760-1Fruit24 g
Kshaudra (Madhu API)HoneyMadhu(-)NANA384 g
Jala APIWaterNANAQ.S.NA
Physico ChemicalTotal Ash: Not more than 1.0 per cent; Appendix 2.2.3. Acid-insoluble ash: Not more than 0.2 per cent; Appendix 2.2.4. Alcohol-soluble extractive: Not less than 45 per cent; Appendix 2.2.7. Water-soluble extractive: Not less than 75 per cent; Appendix 2.2.8 Reducing sugars: 67 to 70 per cent; Appendix 5.1.3.1. Non-reducing sugars: 5.6 to 5.8 per cent; Appendix 5.1.3.3. pH (5% aqueous solution): 4.0 to 4.5; Appendix 3.3. Assay: The formulation contains not less than 0.008 per cent of piperine when assayed by the following method. Estimation of piperine: Dissolve 5 mg of piperine in methanol and make up the volume to 100 ml in a volumetric flask. Pipette out aliquots of 0.8 to 4.8 ml into 10 ml volumetric flasks and adjust the volume in each flask with methanol to prepare standard solutions of 4 to 24 ng / ml. Apply 10 nl of each standard solution on TLC plate. Develop the plate to a distance of 10 cm using dichloromethane : ethyl acetate (7.5 : 1) as mobile phase. After development; dry the plate in air and scan in the TLC scanner at a wavelength of 337 nm. Note the area under the curve for a peak corresponding to piperine and prepare the calibration curve by plotting peak area vs concentration of piperine. Extract; accurately weighed; about 5 g of Kooshmandaka Rasayana in 25 ml portions of ethyl acetate (4 to 5 times); until it tests negative to modified Dragendorff’s reagent. Filter; concentrate the combined extract and adjust the volume to 25 ml in a volumetric flask. Apply 10 nl of the test solution on TLC plate. Develop; dry and scan the plate as described in the preceding paragraph for calibration curve of piperine. Record area under the curve for a peak corresponding to piperine. Calculate the amount of piperine in the test solution from the calibration curve of piperine.
SourceAyurvedic Pharmacopeia of India
DescriptionSemi solid; malleable; sticky preparation; dark brown in color with spicy odour and pungent; sweet taste.
Other RequirementsMicrobial limit Appendix 2.4. Aflatoxin Appendix 2.7.
Dosage20 g daily in divided doses.
Formulation NameKusmandaka Rasayana
Anupana: Water; Milk.
MethodTake all ingredients of pharmacopoeial quality. Wash; dry; powder the ingredients number 4 to 11 (Prakshepa) separately and pass through sieve number 85. Take fresh mature fruit of Kooshmanda; remove skin and seeds and cut in to small pieces of 2.5 to 5 cm. Add double the quantity of water. Heat till Kooshmanda pieces become soft to make pishti maintaining temperature between 900 to 1000. Strain the liquid through muslin cloth. Keep the strained liquid separately and crush the boiled pieces of Kooshmanda in an end runner mill to make a fine paste; fry in Ghrta with constant stirring maintaining temperature between 800 to 900 till the mixture turns brown. Take due care to avoid over roasting or under roasting of pishti Add sugar to the strained liquid and heat to make “two-thread sugar syrup”. Add the fried paste of Kooshmanda to the syrup; heat with constant stirring maintaining temperature between 900to 1000 and observe the mixture for formation of soft bolus; which does not disperse in water. Stop heating and allow to cool to 500. Add fine powders of ingredients (prakshepa) numbered 4 to 11. Mix thoroughly to prepare a homogeneous blend; allow to cool it to room temperature and add Madhu. Pack it in tightly closed containers to protect from light and moisture.
Combined DiseasesKasa, Shvasa, Urahkshata, Kshaya, Puranajvara, Raktapitta, Chardi, Trshna, Jvara, Shukra kshaya, Daurbalya, Karsya, Svarabheda, Vaivarnya .

  • 1. Incoming r'ship IS_INGREDIENT_IN to/from Benincasa Hispida (Plant) Rel Props:Matched_synonym:Benincasa hispida; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_exact; Pharmacopoeia_ref:Kusmanda(Fruit); Quantity:4.8 kg; Part:Fresh Fr.
  • 2. Incoming r'ship IS_INGREDIENT_IN to/from Cinnamomum Tamala (Plant) Rel Props:Matched_synonym:Cinnamomum tamala; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_exact; Pharmacopoeia_ref:Tvakpatra(Leaf); Quantity:24 g; Part:Leaf
  • 3. Incoming r'ship IS_INGREDIENT_IN to/from Cinnamomum Verum (Plant) Rel Props:Matched_synonym:Cinnamomum zeylanicum; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_exact; Pharmacopoeia_ref:Tvak(Bark); Quantity:24 g; Part:Stem bark
  • 4. Incoming r'ship IS_INGREDIENT_IN to/from Cinnamomum Zeylanicum (Plant) Rel Props:Matched_synonym:Cinnamomum zeylanicum; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_exact; Pharmacopoeia_ref:Tvak(Bark); Quantity:24 g; Part:Stem bark
  • 5. Incoming r'ship IS_INGREDIENT_IN to/from Coriandrum Sativum (Plant) Rel Props:Matched_synonym:Dhoney; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_contains; Pharmacopoeia_ref:Madhu(-); Quantity:384 g; Part:Fruit
  • 6. Incoming r'ship IS_INGREDIENT_IN to/from Cuminum Cyminum (Plant) Rel Props:Matched_synonym:Cuminum cyminum; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_exact; Pharmacopoeia_ref:Svetajiraka(Fruit); Quantity:96 g; Part:Fruit
  • 7. Incoming r'ship IS_INGREDIENT_IN to/from Dendrophthoe Falcata (Plant) Rel Props:Matched_synonym:Honey Suckle Mistletoe; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_contains; Pharmacopoeia_ref:Madhu(-); Quantity:384 g
  • 8. Incoming r'ship IS_INGREDIENT_IN to/from Elettaria Cardamomum (Plant) Rel Props:Matched_synonym:Elettaria cardamomum; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_exact; Pharmacopoeia_ref:Suksmaila(Fruit); Quantity:24 g; Part:Seed
  • 9. Incoming r'ship IS_INGREDIENT_IN to/from Gleditsia Triacanthos (Plant) Rel Props:Matched_synonym:Honey Locust; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_contains; Pharmacopoeia_ref:Madhu(-); Quantity:384 g
  • 10. Incoming r'ship IS_INGREDIENT_IN to/from Leonurus Sibiricus (Plant) Rel Props:Matched_synonym:Honeyweed; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_contains; Pharmacopoeia_ref:Madhu(-); Quantity:384 g
  • 11. Incoming r'ship IS_INGREDIENT_IN to/from Lonicera Angustifolia (Plant) Rel Props:Matched_synonym:Narrow-Leaf Honeysuckle; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_contains; Pharmacopoeia_ref:Madhu(-); Quantity:384 g
  • 12. Incoming r'ship IS_INGREDIENT_IN to/from Lonicera Hypoleuca (Plant) Rel Props:Matched_synonym:Yellow Himalayan Honeysuckle; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_contains; Pharmacopoeia_ref:Madhu(-); Quantity:384 g
  • 13. Incoming r'ship IS_INGREDIENT_IN to/from Lonicera Japonica (Plant) Rel Props:Matched_synonym:Japanese Honeysuckle; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_contains; Pharmacopoeia_ref:Madhu(-); Quantity:384 g
  • 14. Incoming r'ship IS_INGREDIENT_IN to/from Lonicera Periclymenum (Plant) Rel Props:Matched_synonym:Dutch Honeysuckle; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_contains; Pharmacopoeia_ref:Madhu(-); Quantity:384 g
  • 15. Incoming r'ship IS_INGREDIENT_IN to/from Lonicera Quinquelocularis (Plant) Rel Props:Matched_synonym:Translucent Honeysuckle; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_contains; Pharmacopoeia_ref:Madhu(-); Quantity:384 g
  • 16. Incoming r'ship IS_INGREDIENT_IN to/from Phyllanthus Reticulatus (Plant) Rel Props:Matched_synonym:Black-Honey Shrub; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_contains; Pharmacopoeia_ref:Madhu(-); Quantity:384 g
  • 17. Incoming r'ship IS_INGREDIENT_IN to/from Piper Longum (Plant) Rel Props:Matched_synonym:Piper longum; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_exact; Pharmacopoeia_ref:Pippali(Fruit); Quantity:96 g; Part:Fruit
  • 18. Incoming r'ship IS_INGREDIENT_IN to/from Piper Nigrum (Plant) Rel Props:Matched_synonym:Piper nigrum; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_exact; Pharmacopoeia_ref:Marica(Fruit); Quantity:24 g; Part:Fruit
  • 19. Incoming r'ship IS_INGREDIENT_IN to/from Tecoma Capensis (Plant) Rel Props:Matched_synonym:Cape Honeysuckle; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_contains; Pharmacopoeia_ref:Madhu(-); Quantity:384 g
  • 20. Incoming r'ship IS_INGREDIENT_IN to/from Zingiber Officinale (Plant) Rel Props:Matched_synonym:Zingiber officinale; Source_db:Ayurvedic Pharmacopeia of India; Match_type:synonym_exact; Pharmacopoeia_ref:Sunthi(Rhizome); Quantity:96 g; Part:Rhizome
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