Ashokarista
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| Storage | Store in a cool place in tightly closed amber coloured bottle; protect from light and moisture. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Physico Chemical | Total phenolic content: 0.061 to 0.083 per cent w/v Appendix 5.1.1 equivalent to tannic acid; Total solids: Not less than 11.0 per cent w/v; Appendix 3.8 Specific gravity (at 250): 1.02 to 1.12; Appendix 3.2 p H: 3.5 to 4.5; Appendix 3.3 Reducing sugars: Not less than 5.50 per cent w/v; Appendix 5.1.3 Non-reducing sugars: Not more than 1.00 per cent w/v; Appendix 5.1.3 Alcohol content: 5 to 10 per cent v/v; Appendix 3.17 Methanol: Absent; Appendix 2.8 Assay: The formulation contains 0.06 to 0.7 per cent w/v gallic acid; when assayed by the following method. Estimation of gallic acid : Apply 1.0 to 8.0 nl of (5 data point) gallic acid solutions prepared under thin layer chromatography on TLC plate and develop the plate to a distance of 8 cm using toluene: ethyl acetate: acetic acid (5 : 4 : 1) as mobile phase. Derivatise the plate with Natural product reagent and dry in a current of cold air and scan in the TLC scanner at a wavelength of 366 nm. Note the area under curve for the peaks corresponding to gallic acid and prepare the calibration curve by plotting peak area vs. concentration of gallic acid. Dry about 50 ml; accurately by measured formulation in vacuum to remove the self generated alcohol. Add 50 ml water to dissolve the extract and partition successively with n-hexane (50 ml x 3); chloroform (50 ml x 3) and ethyl acetate (50 ml x 3). Filter and concentrate the ethyl acetate extract under vacuum and weigh. Dissolve about 20 mg; accurately weighed; residue in 1 ml of methanol taken from a graduated pipette. Apply 5 nl of the test solution on TLC plate. Develop; dry and scan the plate as described above for calibration curve of gallic acid. Calculate the amount of gallic acid in the test solution from the calibration curve of gallic acid. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Description | Clear; dark brown liquid without frothing and significant sedimentation;; with astringent taste | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Other Requirements | Microbial limit: Appendix 2.4 Aflatoxins: Appendix 2.7 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Dosage | 15 – 30 ml orally with equal amount of water after meals twice a day. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Definition | Asokarista is a fermented liquid preparation; made with the ingredients in Formulation composition given below. It contains not more than 10 per cent; and not less than 5 per cent of alcohol that is self generated in the preparation over a period of time. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Source | Ayurvedic Standard Treatment Guidelines; Ayurvedic Pharmacopeia of India; Ayurvedic Formulary of India | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Time Of Administration | After meal / twice a day | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ingredients |
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| Duration | 2-3 month | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Formulation Name | Ashokarista | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Method | Take the raw materials of pharmacopoeial quality. Wash; dry and powder the ingredient numbered 1 (Kvatha Dravya) of the formulation composition and pass through the sieve number 44 to obtain coarse powder. Clean; dry and powder the ingredients numbered 5 to 16 (Praksepa Dravya) of the formulation composition individually and pass through the sieve number 85 to obtain fine powder. Add specified amount of water to the Kvatha Dravya; soak overnight; heat; reduce to one fourth and filter through muslin cloth to obtain Kvatha. Add the ingredient number 3 of the formulation composition to the Kvatha; allow to dissolve and filter through the muslin cloth. Transfer the filtrate to a clean container; add Dhataka and other finely powdered Praksepa Dravyas. Seal the mouth of the container. Shift the container to the fermentation room and constantly check for the signs of completion of fermentation process. Filter the fermented material through a clean muslin cloth. Pack in air tight containers and allow for maturation. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Dosage Form | Arishta | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Combined Diseases | Asrigdara Ruja, Yoniruja, Shvetapradara, Jvara, Raktapitta, Arsa, Mandagni, Arocaka, Meha, Shotha . |
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