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Homocystinuria-Megaloblastic Anemia Cblg Type

Disease ID: disease_node_20519

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DbxrefGARD:3577, MIM:250940, ORDO:2170
SubclassofDOID_0050737, DOID_9252
Data SourceDOID
SynonymsHMAG, homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism cblG complementation type, homocystinuria-megaloblastic anemia, cblG complementation type, methylcobalamin deficiency, cblG type
Doid Labelhomocystinuria-megaloblastic anemia cblG type
Doid DescriptionAn amino acid metabolic disorder characterized by failure of cells to incorporate methyltetrahydrofolate into methionine, impaired methionine synthase activity in the presence of a reducing agent, and somewhat variable features that include delayed psychomotor development, hypotonia, megaloblastic anemia, homocystinuria, and hypomethioninemia that has_material_basis_in homozygous or compound heterozygous mutation in MTR on chromosome 1q43.
Has Material Basis InGENO_0000148
Disease Node Iddisease_node_20519
Doid IdDOID_0112256
LabelHomocystinuria-Megaloblastic Anemia Cblg Type