Amed Syndrome
Disease ID: disease_node_19185
Connections displayed (default: 10).
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| Dbxref | MIM:619151 |
|---|---|
| Subclassof | DOID_225, DOID_0050737, DOID_0080578 |
| Data Source | DOID |
| Synonyms | AMEDS |
| Doid Label | AMED syndrome |
| Doid Description | A syndrome that is characterized by global developmental delay with impaired intellectual development, onset of bone marrow failure and myelodysplastic syndrome in childhood, and poor overall growth with short stature and that has_material_basis_in homozygous or compound heterozygous mutation in the ADH5 gene on chromosome 4q accompanied by a specific homozygous or heterozygous allele in the ALDH2 gene (E504K) on chromosome 12q24. Defects in both of these genes are necessary for the disorder to manifest, consistent with digenic inheritance. |
| Has Material Basis In | GENO_0000148, GENO_0000930 |
| Disease Node Id | disease_node_19185 |
| Doid Id | DOID_0080952 |
| Label | Amed Syndrome |
- Outgoing r'ship
SUBCLASS_OFto/from Syndrome(ID:disease_node_7213) (Disease) - Outgoing r'ship
SUBCLASS_OFto/from Autosomal Recessive Disease(ID:disease_node_13241) (Disease) - Outgoing r'ship
SUBCLASS_OFto/from Digenic Disease(ID:disease_node_13627) (Disease)