Ezb Diffuse Large B-Cell Lymphoma
Disease ID: disease_node_15575
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| Dbxref | NCI:C148398 |
|---|---|
| Subclassof | DOID_0050745 |
| Data Source | DOID |
| Synonyms | EZB DLBCL |
| Doid Label | EZB diffuse large B-cell lymphoma |
| Doid Description | A diffuse large B-cell lymphoma that is categorized as EZB with high probability by the LymphGen algorithm. This is based on a combination of genetic features and EZB DLBCLs often, but do not always, have hot spot mutations in EZH2 and/or a BCL2 translocation. This class can be further subdivided into two sub-classes EZB-MYC+ and EZB-MYC- using the double hit gene expression signature (DHITsig). This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting IRF8, which can be coding or non-coding. |
| Disease Node Id | disease_node_15575 |
| Doid Id | DOID_0081065 |
| Label | Ezb Diffuse Large B-Cell Lymphoma |
- Incoming r'ship
SUBCLASS_OFto/from Ezb-Myc- Diffuse Large B-Cell Lymphoma(ID:disease_node_15576) (Disease) - Incoming r'ship
SUBCLASS_OFto/from Ezb-Myc+ Diffuse Large B-Cell Lymphoma(ID:disease_node_15577) (Disease) - Outgoing r'ship
SUBCLASS_OFto/from Lymphoma, Large B-Cell, Diffuse(ID:disease_node_8702) (Disease)