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Stability of Multidomain protein :
- Residue contacts at Domain interfaces for conjoint and disjoint domains
Ligand-binding induced domain movements
- Movement in single protein structures complexed with different ligands
- Movements in different members of homologus family
Differences in structure environments for a protein domain alone and concidered as part of full protein
- Molecular weight versus solvent accessibility for conjoint and intercating domains
To understand structural invariants in domains with a common fold
Suggestions for experiments from dentrograms
- Folding intermediates from dentrograms
- Protein engineering experiments from dendrograms
Influence of domain folds in substitution tables and in turn secondary structure prediction, stability and model validation
Fold recognition
- Template generation and threading with specific examples
- Prediction of domain boundaries from analysis of sequence length and domain linker propensities
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