SMotif is a server to identify set of
structural motifs from protein structures. Such motifs among
structurally aligned proteins are recognized by the conservation
of amino acid preference and solvent inaccessibility and are
examined for the conservation of other important structural
features like secondary structural content, hydrogen bonding
pattern and residue packing.
An automated method has been developed that
identify protein segments, which form the conserved core in
homologous proteins, using conservation of amino acid exchange,
solvent inaccessibility, secondary structural content, hydrogen
bonding pattern and residue packing.
A structural feature is considered conserved at
an alignment position if it is present in all or all but-one
members within the alignment. The identified structural motifs
are mapped on the alignment using different color code. Ranking
of the motifs is done considering the extent of conservation of
the structural feature. A flavor of the three-dimensional
orientation of the structural motifs is provided via graphic
displays and spatial orientation matrices.
Please click here for different input option usage.
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Dr. R. Sowdhamini
Dr. PN. Suganthan