3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 7FAB

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 L PF13895 Immunoglobulin domain PF13895 PF13895

2 L PF13895 Immunoglobulin domain PF13895 PF13895

3 L PF13927 Immunoglobulin domain PF13927 PF13927

4 H PF13895 Immunoglobulin domain PF13895 PF13895

5 H PF13927 Immunoglobulin domain PF13927 PF13927

6 H PF13927 Immunoglobulin domain PF13927 PF13927

Conserved Domain Database Superfamily Annotations: 7FAB

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 7FAB 212623 cl11960 Ig superfamily - -

2 7FAB 143186 cd04985 IgC_CH1 - cl11960

3 7FAB 212623 cl11960 Ig superfamily - -

4 7FAB 212623 cl11960 Ig superfamily - -

Structural Details of PDB entry 7FAB

Structural Details of PDB entry 7FAB

PDBid Chains Hinge Swapped Domain

7FAB H,L H:42-46,L:43-47 H:1-41,L:1-42

Swapped-domain interface residues and interactions:

Chains Residues
H 39, 103,

L 2, 36, 38, 40,

Non-swapped-domain interface residues and interactions:

Chains Residues
H 44, 45, 47, 50, 58, 61, 94, 98, 100, 102, 104, 105, 107, 108, 126, 127, 128, 129, 141, 145, 147, 148, 168, 170, 171, 172, 173, 175, 176, 181, 183, 185, 213,

L 45, 46, 48, 82, 84, 86, 89, 90, 91, 93, 95, 112, 114, 115, 117, 119, 120, 123, 125, 127, 129, 131, 133, 156, 158, 161, 163, 169, 170, 171, 173, 175, 204,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

H No mutation No mutation No mutation No mutation

L No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

H:7FAB

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 7FAB.ali
atm file: 7FAB.atm
cof file: 7FAB.cof
hbd file: 7FAB.hbd
html file: 7FAB.html
pdb file: 7FAB.pdb
ps file: 7FAB.ps
psa file: 7FAB.psa
rtf file: 7FAB.rtf
sst file: 7FAB.sst
tem file: 7FAB.tem