Pfam Domains mapped on to the structure: 6CSC

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF00285	Citrate synthase	PF00285	PF00285

Conserved Domain Database Superfamily Annotations: 6CSC

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	6CSC	99858	cd06105	ScCit1-2_like -	cl00416
2	6CSC	199305	cl00416	CS_ACL-C_CCL	superfamily - -
3	6CSC	199305	cl00416	CS_ACL-C_CCL	superfamily - -

Structural Details of PDB entry 6CSC PDBid Chains Hinge Swapped Domain 6CSC A,B A:417-425,B:417-425 A:426-437,B:426-437 Swapped-domain interface residues and interactions: Chains Residues A 24, 52, 53, 54, 57, 426, 427, 428, 430, 431, 433, 434, 435, 436, 437, B 23, 24, 27, 52, 53, 54, 57, 426, 427, 430, 431, 433, 434, 435, 436, Non-swapped-domain interface residues and interactions: Chains Residues A 20, 21, 23, 25, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 58, 123, 126, 127, 130, 131, 132, 134, 135, 139, 142, 143, 146, 147, 149, 150, 158, 161, 163, 164, 239, 241, 242, 243, 246, 247, 250, 251, 254, 255, 256, 260, 264, 267, 268, 270, 271, 272, 273, 280, 311, 312, 313, 321, 322, 366, 417, 418, 419, 420, 421, 422, 423, 424, 425, B 20, 21, 25, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 58, 123, 126, 127, 130, 131, 132, 134, 135, 139, 142, 143, 146, 147, 149, 150, 158, 161, 163, 164, 239, 241, 242, 243, 246, 247, 250, 251, 254, 255, 256, 260, 264, 267, 268, 270, 271, 272, 273, 280, 311, 312, 314, 321, 322, 417, 418, 419, 420, 421, 422, 423, 424, 425,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	ILE(52)VAL, ALA(428)ASP, GLU(431)ILE,	ASN(30)GLY, VAL(33)LEU, ASN(163)LEU, LYS(366)ALA,	ALA(428)ASP, GLU(431)ILE, LYS(432)ALA,
B	No mutation	ILE(52)VAL, GLU(431)ILE,	ASN(30)GLY, VAL(33)LEU, ASN(163)LEU,	ALA(428)ASP, GLU(431)ILE, LYS(432)ALA,

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:6CSC

B:6CSC

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	6CSC.ali
atm file:	6CSC.atm
cof file:	6CSC.cof
hbd file:	6CSC.hbd
html file:	6CSC.html
pdb file:	6CSC.pdb
ps file:	6CSC.ps
psa file:	6CSC.psa
rtf file:	6CSC.rtf
sst file:	6CSC.sst
tem file:	6CSC.tem