3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 3FCT

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF13895 Immunoglobulin domain PF13895 PF13895

2 A PF13895 Immunoglobulin domain PF13895 PF13895

3 A PF13927 Immunoglobulin domain PF13927 PF13927

4 A PF13927 Immunoglobulin domain PF13927 PF13927

5 A PF00047 Immunoglobulin domain PF00047 PF00047

6 B PF13895 Immunoglobulin domain PF13895 PF13895

7 B PF13927 Immunoglobulin domain PF13927 PF13927

8 B PF13927 Immunoglobulin domain PF13927 PF13927

Conserved Domain Database Superfamily Annotations: 3FCT

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 3FCT 143182 cd04981 IgV_H - cl11960

2 3FCT 212623 cl11960 Ig superfamily - -

3 3FCT 143186 cd04985 IgC_CH1 - cl11960

4 3FCT 212623 cl11960 Ig superfamily - -

5 3FCT 212623 cl11960 Ig superfamily - -

Structural Details of PDB entry 3FCT

Structural Details of PDB entry 3FCT

PDBid Chains Hinge Swapped Domain

3FCT A,B A:40-44,B:41-45 A:1-39,B:1-40

Swapped-domain interface residues and interactions:

Chains Residues
A 1, 36, 38,

B 39,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 43, 44, 46, 55, 87, 89, 94, 95, 96, 98, 99, 100, 116, 118, 119, 120, 121, 122, 123, 124, 127, 129, 131, 133, 135, 137, 138, 160, 161, 162, 163, 164, 167, 174, 176, 178, 180, 207, 209, 212, 213,

B 44, 45, 47, 50, 59, 61, 95, 100, 101, 102, 104, 105, 106, 123, 124, 125, 126, 129, 130, 133, 136, 138, 142, 144, 165, 167, 168, 170, 171, 172, 180, 182, 184, 210, 215,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:3FCT B:3FCT

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 3FCT.ali
atm file: 3FCT.atm
cof file: 3FCT.cof
hbd file: 3FCT.hbd
html file: 3FCT.html
pdb file: 3FCT.pdb
ps file: 3FCT.ps
psa file: 3FCT.psa
rtf file: 3FCT.rtf
sst file: 3FCT.sst
tem file: 3FCT.tem