3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 3DUW

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF01596 O-methyltransferase PF01596 PF01596

2 A PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF01135 PF01135

3 A PF13847 Methyltransferase domain PF13847 PF13847

4 A PF12847 Methyltransferase domain PF12847 PF12847

5 A PF13578 Methyltransferase domain PF13578 PF13578

Gene Ontology Annotations: 3DUW

No. GO ID GO Description Linkout - AmiGO

1 GO:0008171 O-methyltransferase activity GO:0008171

Conserved Domain Database Superfamily Annotations: 3DUW

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 3DUW 100107 cd02440 AdoMet_MTases - cl16911

2 3DUW 212630 cl16911 AdoMet_MTases superfamily - -

3 3DUW 212630 cl16911 AdoMet_MTases superfamily - -

Structural Details of PDB entry 3DUW

Structural Details of PDB entry 3DUW

PDBid Chains Hinge Swapped Domain

3DUW A,B A:202-205,B:202-205 A:206-222,B:206-222

Swapped-domain interface residues and interactions:

Chains Residues
A 205, 206, 207, 208, 213, 216, 220, 222,

B 205, 206, 207, 208, 213, 216, 220,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 6, 7, 9, 10, 11, 13, 14, 17, 18, 45, 46, 48, 49, 52, 53, 55, 56, 57, 162, 172, 174, 175, 188, 191, 192, 194, 195, 201, 202, 203, 204,

B 6, 7, 9, 10, 11, 13, 14, 17, 18, 45, 46, 48, 49, 52, 53, 55, 56, 57, 162, 172, 174, 175, 188, 191, 192, 194, 195, 201, 202, 203, 204,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:3DUW B:3DUW

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 3DUW.ali
atm file: 3DUW.atm
cof file: 3DUW.cof
hbd file: 3DUW.hbd
html file: 3DUW.html
pdb file: 3DUW.pdb
ps file: 3DUW.ps
psa file: 3DUW.psa
rtf file: 3DUW.rtf
sst file: 3DUW.sst
tem file: 3DUW.tem