3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 3DMS

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00180 Isocitrate/isopropylmalate dehydrogenase PF00180 PF00180

Conserved Domain Database Superfamily Annotations: 3DMS

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 3DMS 212218 cl00445 Iso_dh superfamily - -

2 3DMS 212218 cl00445 Iso_dh superfamily - -

Structural Details of PDB entry 3DMS

Structural Details of PDB entry 3DMS

PDBid Chains Hinge Swapped Domain

3DMS A,B A:161-166,B:161-166 A:3-160,B:3-160

Swapped-domain interface residues and interactions:

Chains Residues
A 114, 115, 118, 125, 141, 142, 143, 144, 158, 159, 191, 292, 293,

B 114, 115, 118, 125, 141, 142, 143, 144, 158, 159, 191, 292, 293,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 173, 176, 177, 180, 181, 184, 185, 187, 189, 190, 192, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 210, 232, 235, 236, 237, 238, 239, 242, 284, 285, 288, 289, 294, 306, 307, 309, 310, 313, 314, 317, 318, 320, 322, 397, 419,

B 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 173, 176, 177, 180, 181, 184, 185, 187, 189, 190, 192, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 210, 232, 235, 236, 237, 238, 239, 242, 284, 285, 288, 289, 294, 306, 307, 309, 310, 313, 314, 317, 318, 320, 322, 397,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:3DMS B:3DMS

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 3DMS.ali
atm file: 3DMS.atm
cof file: 3DMS.cof
hbd file: 3DMS.hbd
html file: 3DMS.html
pdb file: 3DMS.pdb
ps file: 3DMS.ps
psa file: 3DMS.psa
rtf file: 3DMS.rtf
sst file: 3DMS.sst
tem file: 3DMS.tem