3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 3D85

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF13895 Immunoglobulin domain PF13895 PF13895

2 A PF13895 Immunoglobulin domain PF13895 PF13895

3 A PF13927 Immunoglobulin domain PF13927 PF13927

4 A PF13927 Immunoglobulin domain PF13927 PF13927

5 A PF00047 Immunoglobulin domain PF00047 PF00047

6 B PF13927 Immunoglobulin domain PF13927 PF13927

7 C PF00489 Interleukin-6/G-CSF/MGF family PF00489 PF00489

8 D PF10420 Cytokine interleukin-12p40 C-terminus PF10420 PF10420

Gene Ontology Annotations: 3D85

No. GO ID GO Description Linkout - AmiGO

1 GO:0005576 extracellular region GO:0005576

Conserved Domain Database Superfamily Annotations: 3D85

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 3D85 151001 cl11074 IL12p40_C superfamily - -

2 3D85 212623 cl11960 Ig superfamily - -

Structural Details of PDB entry 3D85

Structural Details of PDB entry 3D85

PDBid Chains Hinge Swapped Domain

3D85 A,B A:41-44,B:42-45 A:1-40,B:1-41

Swapped-domain interface residues and interactions:

Chains Residues
A 1, 34, 36, 38,

B 39,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 41, 43, 44, 46, 49, 50, 55, 87, 89, 94, 95, 96, 98, 100, 116, 117, 118, 119, 121, 122, 123, 124, 129, 131, 133, 135, 137, 138, 160, 162, 163, 164, 167, 174, 176, 178, 208, 213,

B 44, 45, 47, 50, 59, 61, 63, 95, 100, 101, 103, 105, 106, 124, 125, 126, 127, 129, 131, 133, 137, 139, 143, 145, 166, 167, 168, 169, 171, 173, 181, 183, 185, 211, 216,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:3D85 B:3D85

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 3D85.ali
atm file: 3D85.atm
cof file: 3D85.cof
hbd file: 3D85.hbd
html file: 3D85.html
pdb file: 3D85.pdb
ps file: 3D85.ps
psa file: 3D85.psa
rtf file: 3D85.rtf
sst file: 3D85.sst
tem file: 3D85.tem