Pfam Domains mapped on to the structure: 3BIO

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF02629	CoA binding domain	PF02629	PF02629
2	A	PF01408	Oxidoreductase family, NAD-binding Rossmann fold	PF01408	PF01408
3	A	PF01118	Semialdehyde dehydrogenase, NAD binding domain	PF01118	PF01118

Gene Ontology Annotations: 3BIO

No.	GO ID	GO Description	Linkout - AmiGO
1	GO:0016491	oxidoreductase activity	GO:0016491

Conserved Domain Database Superfamily Annotations: 3BIO

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	3BIO	212616	NADB_Rossmann	superfamily	C -
2	3BIO	212616	NADB_Rossmann	superfamily	C -

Structural Details of PDB entry 3BIO PDBid Chains Hinge Swapped Domain 3BIO A,B A:280-284,B:280-284 A:285-301,B:285-301 Swapped-domain interface residues and interactions: Chains Residues A 100, 129, 130, 132, 133, 134, 137, 281, 282, 285, 286, 288, 289, 293, 294, 296, 297, 298, 300, B 100, 129, 130, 132, 133, 134, 137, 281, 282, 285, 286, 288, 289, 293, 294, 296, 297, 298, 300, Non-swapped-domain interface residues and interactions: Chains Residues A 23, 24, 27, 96, 99, 103, 127, 131, 136, 138, 140, 141, 239, 240, 241, 242, 245, 246, 248, 249, 250, 252, 253, 254, 257, 258, 261, 262, 265, 279, 284, B 23, 24, 27, 96, 99, 103, 127, 131, 136, 138, 140, 141, 239, 240, 241, 242, 245, 246, 248, 249, 250, 252, 253, 254, 257, 258, 261, 262, 265, 279, 284,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:3BIO

B:3BIO

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	3BIO.ali
atm file:	3BIO.atm
cof file:	3BIO.cof
hbd file:	3BIO.hbd
html file:	3BIO.html
pdb file:	3BIO.pdb
ps file:	3BIO.ps
psa file:	3BIO.psa
rtf file:	3BIO.rtf
sst file:	3BIO.sst
tem file:	3BIO.tem