3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2R8S

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 L PF13895 Immunoglobulin domain PF13895 PF13895

2 L PF13895 Immunoglobulin domain PF13895 PF13895

3 L PF13927 Immunoglobulin domain PF13927 PF13927

4 L PF13927 Immunoglobulin domain PF13927 PF13927

5 L PF00047 Immunoglobulin domain PF00047 PF00047

6 H PF13927 Immunoglobulin domain PF13927 PF13927

Conserved Domain Database Superfamily Annotations: 2R8S

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2R8S 143182 cd04981 IgV_H - cl11960

2 2R8S 212623 cl11960 Ig superfamily - -

3 2R8S 143186 cd04985 IgC_CH1 - cl11960

4 2R8S 212623 cl11960 Ig superfamily - -

5 2R8S 212623 cl11960 Ig superfamily - -

Structural Details of PDB entry 2R8S

Structural Details of PDB entry 2R8S

PDBid Chains Hinge Swapped Domain

2R8S H,L H:106-108,L:95-97 H:1-105,L:1-94

Swapped-domain interface residues and interactions:

Chains Residues
H 39, 44, 45, 47, 59, 95, 99, 104, 105, 106, 107, 108, 109, 111, 113,

L 32, 34, 36, 38, 41, 43, 44, 46, 49, 50, 55, 87, 89, 91, 94, 96, 98, 100,

Non-swapped-domain interface residues and interactions:

Chains Residues
H 130, 131, 132, 133, 143, 145, 149, 151, 172, 174, 175, 177, 179, 187, 189, 191, 217, 222, 223,

L 95, 116, 118, 119, 121, 123, 124, 129, 131, 133, 135, 137, 138, 160, 162, 163, 164, 165, 167, 174, 176, 178, 180, 212, 213, 214,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

H No mutation No mutation No mutation No mutation

L No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

H:2R8S

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2R8S.ali
atm file: 2R8S.atm
cof file: 2R8S.cof
hbd file: 2R8S.hbd
html file: 2R8S.html
pdb file: 2R8S.pdb
ps file: 2R8S.ps
psa file: 2R8S.psa
rtf file: 2R8S.rtf
sst file: 2R8S.sst
tem file: 2R8S.tem