3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2R3S

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00891 O-methyltransferase PF00891 PF00891

2 A PF05175 Methyltransferase small domain PF05175 PF05175

3 A PF10294 Putative methyltransferase PF10294 PF10294

4 A PF13847 Methyltransferase domain PF13847 PF13847

5 A PF12847 Methyltransferase domain PF12847 PF12847

6 A PF08242 Methyltransferase domain PF08242 PF08242

Gene Ontology Annotations: 2R3S

No. GO ID GO Description Linkout - AmiGO

1 GO:0008168 methyltransferase activity GO:0008168

Conserved Domain Database Superfamily Annotations: 2R3S

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2R3S 144476 cl16913 Methyltransf_2 superfamily - -

2 2R3S 144476 cl16913 Methyltransf_2 superfamily - -

Structural Details of PDB entry 2R3S

Structural Details of PDB entry 2R3S

PDBid Chains Hinge Swapped Domain

2R3S A,B A:109-112,B:109-112 A:3-108,B:3-108

Swapped-domain interface residues and interactions:

Chains Residues
A 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 24, 27, 28, 49, 50, 51, 53, 54, 56, 58, 60, 61, 63, 64, 65, 66, 67, 70, 79, 80, 84, 85, 93, 94, 96, 97, 100, 101, 106, 109, 110, 112, 113, 116, 117, 119, 277, 278, 281, 285, 288, 291, 296,

B 4, 5, 6, 8, 9, 10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 27, 28, 49, 50, 51, 53, 54, 56, 58, 60, 61, 63, 64, 65, 66, 67, 70, 79, 80, 84, 85, 93, 94, 96, 97, 100, 101, 106, 109, 112, 113, 116, 117, 119, 278, 281, 285, 288, 291,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 276, 284, 287, 289, 297, 298, 334,

B 276, 277, 282, 284, 287, 289, 296, 297, 298,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2R3S B:2R3S

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2R3S.ali
atm file: 2R3S.atm
cof file: 2R3S.cof
hbd file: 2R3S.hbd
html file: 2R3S.html
pdb file: 2R3S.pdb
ps file: 2R3S.ps
psa file: 2R3S.psa
rtf file: 2R3S.rtf
sst file: 2R3S.sst
tem file: 2R3S.tem