3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2QQK

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00431 CUB domain PF00431 PF00431

2 A PF00431 CUB domain PF00431 PF00431

3 A PF00754 F5/8 type C domain PF00754 PF00754

4 A PF00754 F5/8 type C domain PF00754 PF00754

5 L PF13895 Immunoglobulin domain PF13895 PF13895

6 L PF13895 Immunoglobulin domain PF13895 PF13895

7 L PF13927 Immunoglobulin domain PF13927 PF13927

8 L PF13927 Immunoglobulin domain PF13927 PF13927

9 L PF00047 Immunoglobulin domain PF00047 PF00047

Conserved Domain Database Superfamily Annotations: 2QQK

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2QQK 143181 cd04980 IgV_L_kappa - cl11960

2 2QQK 212623 cl11960 Ig superfamily - -

3 2QQK 143323 cd07699 IgC_L - cl11960

4 2QQK 212623 cl11960 Ig superfamily - -

5 2QQK 212623 cl11960 Ig superfamily - -

Structural Details of PDB entry 2QQK

Structural Details of PDB entry 2QQK

PDBid Chains Hinge Swapped Domain

2QQK H,L H:42-45,L:41-44 H:1-41,L:1-40

Swapped-domain interface residues and interactions:

Chains Residues
H 39,

L 1, 32, 34, 36, 38,

Non-swapped-domain interface residues and interactions:

Chains Residues
H 44, 45, 47, 50, 56, 58, 60, 61, 91, 100, 101, 102, 103, 104, 105, 122, 123, 124, 125, 135, 137, 141, 143, 164, 166, 167, 169, 171, 179, 181, 183, 209, 220,

L 43, 44, 46, 49, 50, 53, 55, 87, 89, 91, 92, 93, 94, 95, 96, 98, 100, 116, 118, 119, 121, 123, 124, 127, 129, 131, 133, 135, 137, 138, 160, 161, 162, 163, 164, 167, 174, 176, 178, 180,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

H No mutation No mutation No mutation No mutation

L No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

H:2QQK L:2QQK

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2QQK.ali
atm file: 2QQK.atm
cof file: 2QQK.cof
hbd file: 2QQK.hbd
html file: 2QQK.html
pdb file: 2QQK.pdb
ps file: 2QQK.ps
psa file: 2QQK.psa
rtf file: 2QQK.rtf
sst file: 2QQK.sst
tem file: 2QQK.tem