Pfam Domains mapped on to the structure: 2P4W

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF12840	Helix-turn-helix domain	PF12840	PF12840
2	A	PF01022	Bacterial regulatory protein, arsR family	PF01022	PF01022
3	A	PF01978	Sugar-specific transcriptional regulator TrmB	PF01978	PF01978

Conserved Domain Database Superfamily Annotations: 2P4W

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2P4W	28974	cd00090	HTH_ARSR -	cl00088
2	2P4W	212173	cl00088	HTH	superfamily - -
3	2P4W	212173	cl00088	HTH	superfamily - -

Structural Details of PDB entry 2P4W PDBid Chains Hinge Swapped Domain 2P4W A,B A:88-90,B:88-90 A:1-87,B:1-87 Swapped-domain interface residues and interactions: Chains Residues A 1, 6, 9, 10, 12, 13, 15, 18, 19, 21, 22, 25, 26, 76, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 91, B 1, 6, 9, 10, 12, 13, 15, 18, 19, 21, 22, 25, 76, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 91, Non-swapped-domain interface residues and interactions: Chains Residues A 94, 96, 98, 101, 102, 104, 106, 107, 110, 114, 120, 121, 123, 124, 125, 127, 128, 129, 131, 132, 134, 135, 137, 138, 139, 141, 142, 143, 144, 145, 146, 147, 148, 150, 151, 152, 154, 155, 156, 158, 159, 162, 163, 166, 176, 177, 180, 181, 184, 185, 186, 197, B 96, 98, 102, 104, 106, 107, 110, 114, 120, 121, 123, 124, 125, 127, 128, 129, 131, 132, 134, 135, 137, 138, 141, 142, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 158, 159, 160, 162, 163, 164, 166, 176, 177, 180, 181, 184, 185, 186, 196,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2P4W

B:2P4W

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2P4W.ali
atm file:	2P4W.atm
cof file:	2P4W.cof
hbd file:	2P4W.hbd
html file:	2P4W.html
pdb file:	2P4W.pdb
ps file:	2P4W.ps
psa file:	2P4W.psa
rtf file:	2P4W.rtf
sst file:	2P4W.sst
tem file:	2P4W.tem