3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2P2W

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00285 Citrate synthase PF00285 PF00285

Conserved Domain Database Superfamily Annotations: 2P2W

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2P2W 99871 cd06118 citrate_synt_like_1 - cl00416

2 2P2W 199305 cl00416 CS_ACL-C_CCL superfamily - -

3 2P2W 199305 cl00416 CS_ACL-C_CCL superfamily - -

Structural Details of PDB entry 2P2W

Structural Details of PDB entry 2P2W

PDBid Chains Hinge Swapped Domain

2P2W A,B A:340-352,B:340-352 A:353-365,B:353-365

Swapped-domain interface residues and interactions:

Chains Residues
A 30, 31, 56, 57, 353, 354, 355, 357, 360, 363, 364, 365,

B 30, 31, 56, 57, 353, 354, 355, 357, 360, 363, 364,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17, 18, 29, 35, 36, 39, 44, 54, 55, 58, 60, 76, 79, 80, 83, 84, 85, 87, 88, 92, 95, 96, 99, 100, 101, 177, 178, 179, 180, 183, 184, 187, 188, 191, 192, 193, 194, 197, 200, 201, 204, 205, 207, 208, 209, 210, 251, 252, 336, 339, 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352,

B 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17, 18, 29, 35, 36, 39, 44, 54, 55, 58, 60, 76, 79, 80, 83, 84, 85, 87, 88, 92, 95, 96, 99, 100, 101, 177, 178, 179, 180, 183, 184, 187, 188, 191, 192, 193, 194, 197, 200, 201, 204, 205, 207, 208, 209, 210, 251, 252, 336, 339, 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2P2W B:2P2W

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2P2W.ali
atm file: 2P2W.atm
cof file: 2P2W.cof
hbd file: 2P2W.hbd
html file: 2P2W.html
pdb file: 2P2W.pdb
ps file: 2P2W.ps
psa file: 2P2W.psa
rtf file: 2P2W.rtf
sst file: 2P2W.sst
tem file: 2P2W.tem