Pfam Domains mapped on to the structure: 2NY4

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF00516	Envelope glycoprotein GP120	PF00516	PF00516
2	A	PF00516	Envelope glycoprotein GP120	PF00516	PF00516
3	A	PF00516	Envelope glycoprotein GP120	PF00516	PF00516
4	B	PF11465	Natural killer cell receptor 2B4	PF11465	PF11465
5	B	PF13895	Immunoglobulin domain	PF13895	PF13895
6	B	PF13895	Immunoglobulin domain	PF13895	PF13895
7	B	PF00047	Immunoglobulin domain	PF00047	PF00047
8	C	PF13895	Immunoglobulin domain	PF13895	PF13895
9	C	PF13895	Immunoglobulin domain	PF13895	PF13895
10	C	PF13927	Immunoglobulin domain	PF13927	PF13927
11	C	PF13927	Immunoglobulin domain	PF13927	PF13927
12	C	PF00047	Immunoglobulin domain	PF00047	PF00047
13	D	PF13927	Immunoglobulin domain	PF13927	PF13927

Conserved Domain Database Superfamily Annotations: 2NY4

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2NY4	143182	cd04981	IgV_H -	cl11960
2	2NY4	212623	cl11960	Ig	superfamily - -
3	2NY4	143186	cd04985	IgC_CH1 -	cl11960
4	2NY4	212623	cl11960	Ig	superfamily - -
5	2NY4	212623	cl11960	Ig	superfamily - -

Structural Details of PDB entry 2NY4 PDBid Chains Hinge Swapped Domain 2NY4 D,C D:3102-3117,C:2094-2099 D:3001-3101,C:2001-2093 Swapped-domain interface residues and interactions: Chains Residues C 2036, 2038, 2043, 2044, 2046, 2049, 2055, 2056, 2087, 2089, 2091, 2096, 2098, 2100, 2102, D 3039, 3043, 3044, 3045, 3047, 3050, 3059, 3062, 3095, 3113, 3114, 3115, 3116, 3118, 3120, Non-swapped-domain interface residues and interactions: Chains Residues C 2094, 2095, 2097, 2118, 2120, 2121, 2123, 2125, 2126, 2129, 2131, 2133, 2135, 2137, 2139, 2140, 2162, 2163, 2164, 2165, 2166, 2169, 2176, 2178, 2180, 2182, 2214, D 3111, 3119, 3137, 3138, 3139, 3140, 3150, 3152, 3156, 3158, 3179, 3181, 3182, 3184, 3185, 3186, 3194, 3196, 3198, 3224,

Swapped domains are represented using trasperent spheres. Non-swapped part is reprented using light color and cartoon reprentation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
D	No mutation	No mutation	No mutation	No mutation
C	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

3:2NY4

D:2NY4

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2NY4.ali
atm file:	2NY4.atm
cof file:	2NY4.cof
hbd file:	2NY4.hbd
html file:	2NY4.html
pdb file:	2NY4.pdb
ps file:	2NY4.ps
psa file:	2NY4.psa
rtf file:	2NY4.rtf
sst file:	2NY4.sst
tem file:	2NY4.tem