Pfam Domains mapped on to the structure: 2NW8

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF03301	Tryptophan 2,3-dioxygenase	PF03301	PF03301
2	A	PF03301	Tryptophan 2,3-dioxygenase	PF03301	PF03301

Gene Ontology Annotations: 2NW8

No.	GO ID	GO Description	Linkout - AmiGO
1	GO:0055114	oxidation-reduction process	GO:0055114

Conserved Domain Database Superfamily Annotations: 2NW8

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2NW8	189171	cl03994	Trp_dioxygenase	superfamily - -

Structural Details of PDB entry 2NW8 PDBid Chains Hinge Swapped Domain 2NW8 A,B A:39-44,B:39-44 A:19-38,B:19-38 Swapped-domain interface residues and interactions: Chains Residues A 19, 21, 22, 24, 27, 28, 29, 30, 32, 33, 34, 35, 36, 37, 38, 52, 56, 120, 121, 122, 123, 124, 125, 127, 128, B 21, 22, 23, 24, 25, 27, 28, 29, 30, 32, 33, 34, 35, 36, 37, 38, 52, 56, 120, 121, 123, 124, 127, Non-swapped-domain interface residues and interactions: Chains Residues A 40, 46, 47, 49, 50, 53, 55, 57, 59, 60, 61, 63, 64, 67, 68, 71, 86, 89, 90, 93, 96, 97, 100, 101, 103, 104, 107, 109, 112, 130, 151, 284, B 40, 46, 47, 49, 50, 51, 53, 55, 57, 59, 60, 61, 63, 64, 67, 68, 71, 86, 89, 90, 93, 96, 97, 100, 101, 103, 104, 107, 109, 112, 119, 122, 125, 128, 130, 151,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2NW8

B:2NW8

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2NW8.ali
atm file:	2NW8.atm
cof file:	2NW8.cof
hbd file:	2NW8.hbd
html file:	2NW8.html
pdb file:	2NW8.pdb
ps file:	2NW8.ps
psa file:	2NW8.psa
rtf file:	2NW8.rtf
sst file:	2NW8.sst
tem file:	2NW8.tem