3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2J90

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00069 Protein kinase domain PF00069 PF00069

2 A PF07714 Protein tyrosine kinase PF07714 PF07714

3 A PF06293 Lipopolysaccharide kinase (Kdo/WaaP) family PF06293 PF06293

Gene Ontology Annotations: 2J90

No. GO ID GO Description Linkout - AmiGO

1 GO:0016020 membrane GO:0016020

Conserved Domain Database Superfamily Annotations: 2J90

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2J90 212301 cl09925 PKc_like superfamily - -

2 2J90 212301 cl09925 PKc_like superfamily - -

Structural Details of PDB entry 2J90

Structural Details of PDB entry 2J90

PDBid Chains Hinge Swapped Domain

2J90 A,B A:168-171,B:168-171;A:190-194,B:190-194 A:172-189,B:172-189

Swapped-domain interface residues and interactions:

Chains Residues
A 139, 141, 164, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 198, 201, 202, 205, 218, 225, 226, 229, 230, 258,

B 141, 172, 173, 174, 175, 176, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 198, 201, 202, 205, 218, 222, 225, 226, 229, 230, 258,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 23, 60, 63, 134, 138, 140, 142, 143, 166, 169, 190, 191, 194, 209, 215, 222, 260, 263, 278,

B 47, 51, 138, 140, 142, 143, 190, 191, 194, 209, 215, 260, 263,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2J90 B:2J90

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2J90.ali
atm file: 2J90.atm
cof file: 2J90.cof
hbd file: 2J90.hbd
html file: 2J90.html
pdb file: 2J90.pdb
ps file: 2J90.ps
psa file: 2J90.psa
rtf file: 2J90.rtf
sst file: 2J90.sst
tem file: 2J90.tem