3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2J7T

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00069 Protein kinase domain PF00069 PF00069

2 A PF07714 Protein tyrosine kinase PF07714 PF07714

Gene Ontology Annotations: 2J7T

No. GO ID GO Description Linkout - AmiGO

1 GO:0006468 protein phosphorylation GO:0006468

Conserved Domain Database Superfamily Annotations: 2J7T

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2J7T 132975 cd06644 STKc_STK10_LOK - cl09925

2 2J7T 212301 cl09925 PKc_like superfamily - -

3 2J7T 212301 cl09925 PKc_like superfamily - -

Structural Details of PDB entry 2J7T

Structural Details of PDB entry 2J7T

PDBid Chains Hinge Swapped Domain

2J7T A,B A:188-193,B:188-193;A:210-215,B:210-215 A:194-209,B:194-209

Swapped-domain interface residues and interactions:

Chains Residues
A 156, 157, 158, 159, 178, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 209, 218, 221, 222, 225, 235, 236, 242, 245, 246, 249, 250, 277,

B 156, 157, 158, 159, 178, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 209, 218, 221, 222, 225, 235, 236, 242, 245, 246, 249, 250, 277,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 182, 185, 193, 229, 238, 279, 282, 317,

B 182, 185, 193, 229, 238, 279, 282,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2J7T B:2J7T

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2J7T.ali
atm file: 2J7T.atm
cof file: 2J7T.cof
hbd file: 2J7T.hbd
html file: 2J7T.html
pdb file: 2J7T.pdb
ps file: 2J7T.ps
psa file: 2J7T.psa
rtf file: 2J7T.rtf
sst file: 2J7T.sst
tem file: 2J7T.tem