3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2IV0

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00180 Isocitrate/isopropylmalate dehydrogenase PF00180 PF00180

Conserved Domain Database Superfamily Annotations: 2IV0

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2IV0 212218 cl00445 Iso_dh superfamily - -

2 2IV0 212218 cl00445 Iso_dh superfamily - -

3 2IV0 212218 cl00445 Iso_dh superfamily - -

Structural Details of PDB entry 2IV0

Structural Details of PDB entry 2IV0

PDBid Chains Hinge Swapped Domain

2IV0 A,B A:158-159,B:158-159 A:160-190,B:160-190

Swapped-domain interface residues and interactions:

Chains Residues
A 160, 161, 162, 163, 167, 170, 171, 174, 175, 179, 181, 183, 184, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 229, 230,

B 160, 161, 162, 163, 167, 170, 171, 174, 175, 178, 179, 181, 183, 184, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 229, 230,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 107, 135, 136, 137, 138, 153, 155, 156, 158, 159, 197, 223, 225, 226, 227, 228, 237, 276, 277, 278, 280, 281, 284, 285, 286, 298, 299, 301, 302, 305, 306, 309, 310, 313, 314, 389, 412,

B 106, 107, 135, 136, 137, 138, 155, 156, 158, 159, 197, 223, 225, 226, 227, 228, 237, 276, 277, 278, 280, 281, 284, 285, 286, 298, 299, 301, 302, 305, 306, 309, 310, 313, 314, 389,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2IV0 B:2IV0

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2IV0.ali
atm file: 2IV0.atm
cof file: 2IV0.cof
hbd file: 2IV0.hbd
html file: 2IV0.html
pdb file: 2IV0.pdb
ps file: 2IV0.ps
psa file: 2IV0.psa
rtf file: 2IV0.rtf
sst file: 2IV0.sst
tem file: 2IV0.tem