3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2IO2

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF02902 Ulp1 protease family, C-terminal catalytic domain PF02902 PF02902

2 B PF00240 Ubiquitin family PF00240 PF00240

3 C PF07834 RanGAP1 C-terminal domain PF07834 PF07834

Gene Ontology Annotations: 2IO2

No. GO ID GO Description Linkout - AmiGO

1 GO:0007165 signal transduction GO:0007165

Conserved Domain Database Superfamily Annotations: 2IO2

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2IO2 203777 cl06737 RanGAP1_C superfamily - -

2 2IO2 203777 cl06737 RanGAP1_C superfamily - -

Structural Details of PDB entry 2IO2

Structural Details of PDB entry 2IO2

PDBid Chains Hinge Swapped Domain

2IO2 A,B A:524-536,B:524-536;A:566-577,B:566-577 A:537-565,B:537-565

Swapped-domain interface residues and interactions:

Chains Residues
A 541, 542, 543, 544, 545, 546, 548,

B 96,

C 523, 524,

E 562, 565, 567,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 383, 384, 385, 386, 394, 395, 396, 398, 401, 406, 407, 408, 409, 410, 412, 413, 414, 439, 441, 445, 447, 456, 457, 459, 474, 476, 477, 479, 497, 498, 499, 500, 503, 507, 536, 589,

B 30, 31, 32, 45, 49, 52, 53, 55, 56, 58, 59, 60, 63, 65, 67, 68, 69, 70, 72, 73, 74, 75, 89, 91, 93, 94, 95,

C 435, 436, 439, 440, 441, 442, 443, 444, 465, 466, 467, 471, 473, 474, 475, 477, 478, 480, 481, 482, 484, 487, 490, 491, 494, 495, 498, 499, 502, 508, 509, 510, 511, 512, 513, 514, 515, 516, 517, 520, 522, 525, 526, 527, 528, 529, 530, 531, 532, 533, 535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 550, 552, 555, 556, 558, 559, 560, 562, 563, 564, 565, 566, 567, 568, 569, 570, 571, 572, 574, 575, 576, 577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587,

D 30, 31, 32, 45, 49, 52, 53, 55, 56, 58, 59, 60, 63, 65, 67, 68, 69, 70, 72, 73, 74, 75, 89, 91, 93, 94, 95, 96,

E 435, 436, 439, 440, 441, 442, 443, 444, 465, 466, 467, 471, 473, 474, 475, 477, 478, 480, 481, 482, 484, 487, 490, 491, 494, 495, 498, 499, 502, 508, 509, 510, 511, 512, 513, 514, 515, 516, 517, 520, 522, 523, 524, 525, 526, 527, 528, 529, 530, 531, 532, 533, 535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 550, 552, 555, 556, 558, 559, 560, 563, 564, 566, 568, 569, 570, 571, 572, 574, 575, 576, 577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587,

F 383, 384, 385, 386, 394, 395, 396, 398, 401, 406, 407, 408, 409, 410, 412, 413, 414, 439, 441, 445, 447, 456, 457, 459, 474, 476, 477, 479, 497, 498, 499, 500, 503, 507, 536, 541, 542, 543, 544, 545, 546, 548, 589,

G 435, 436, 439, 440, 441, 442, 443, 444, 465, 466, 467, 471, 473, 474, 475, 477, 478, 480, 481, 482, 484, 487, 490, 491, 494, 495, 498, 499, 502, 508, 509, 510, 511, 512, 513, 514, 515, 516, 517, 520, 522, 523, 524, 525, 526, 527, 528, 529, 530, 531, 532, 533, 535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 550, 552, 555, 556, 558, 559, 560, 562, 563, 564, 565, 566, 567, 568, 569, 570, 571, 572, 574, 575, 576, 577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587,

H 383, 384, 385, 386, 394, 395, 396, 398, 401, 406, 407, 408, 409, 410, 412, 413, 414, 439, 441, 445, 447, 456, 457, 459, 474, 476, 477, 479, 497, 498, 499, 500, 503, 507, 536, 541, 542, 543, 544, 545, 546, 548, 589,

I 30, 31, 32, 45, 49, 52, 53, 55, 56, 58, 59, 60, 63, 65, 67, 68, 69, 70, 72, 73, 74, 75, 89, 91, 93, 94, 95, 96,

J 435, 436, 439, 440, 441, 442, 443, 444, 465, 466, 467, 471, 473, 474, 475, 477, 478, 480, 481, 482, 484, 487, 490, 491, 494, 495, 498, 499, 502, 508, 509, 510, 511, 512, 513, 514, 515, 516, 517, 520, 522, 523, 524, 525, 526, 527, 528, 529, 530, 531, 532, 533, 535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 550, 552, 555, 556, 558, 559, 560, 562, 563, 564, 565, 566, 567, 568, 569, 570, 571, 572, 574, 575, 576, 577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587,

K 383, 384, 385, 386, 394, 395, 396, 398, 401, 406, 407, 408, 409, 410, 412, 413, 414, 439, 441, 445, 447, 456, 457, 459, 474, 476, 477, 479, 497, 498, 499, 500, 503, 507, 536, 541, 542, 543, 544, 545, 546, 548, 589,

L 30, 31, 32, 45, 49, 52, 53, 55, 56, 58, 59, 60, 63, 65, 67, 68, 69, 70, 72, 73, 74, 75, 89, 91, 93, 94, 95, 96,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2IO2 L:2IO2

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2IO2.ali
atm file: 2IO2.atm
cof file: 2IO2.cof
hbd file: 2IO2.hbd
html file: 2IO2.html
pdb file: 2IO2.pdb
ps file: 2IO2.ps
psa file: 2IO2.psa
rtf file: 2IO2.rtf
sst file: 2IO2.sst
tem file: 2IO2.tem