Pfam Domains mapped on to the structure: 2ILK

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF00726	Interleukin 10	PF00726	PF00726

Conserved Domain Database Superfamily Annotations: 2ILK

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2ILK	141468	cl02501	IL10	superfamily - -

Structural Details of PDB entry 2ILK PDBid Chains Hinge Swapped Domain 2ILK A,B A:141-144,B:141-144 A:145-160,B:145-160 Swapped-domain interface residues and interactions: Chains Residues A 53, 56, 57, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 156, 157, 158, 160, B 53, 56, 57, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 156, 157, 158, Non-swapped-domain interface residues and interactions: Chains Residues A 6, 7, 16, 19, 20, 23, 26, 27, 30, 37, 38, 40, 41, 42, 43, 45, 46, 47, 48, 51, 52, 55, 59, 60, 61, 62, 63, 64, 65, 67, 68, 71, 72, 75, 76, 77, 79, 80, 83, 94, 98, 101, 105, 110, 111, 113, 114, 116, 117, 118, 120, 121, 123, 124, 125, 127, 128, 131, 134, 136, 137, 138, 139, 140, 141, 142, 143, 144, B 6, 7, 16, 19, 20, 23, 26, 27, 30, 37, 38, 40, 41, 42, 43, 45, 46, 47, 48, 51, 52, 55, 59, 60, 61, 62, 63, 64, 65, 67, 68, 71, 72, 75, 76, 77, 79, 80, 83, 94, 98, 101, 105, 110, 111, 113, 114, 116, 117, 118, 120, 121, 123, 124, 125, 127, 128, 131, 134, 136, 137, 138, 139, 140, 141, 142, 143, 144,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2ILK

B:2ILK

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2ILK.ali
atm file:	2ILK.atm
cof file:	2ILK.cof
hbd file:	2ILK.hbd
html file:	2ILK.html
pdb file:	2ILK.pdb
ps file:	2ILK.ps
psa file:	2ILK.psa
rtf file:	2ILK.rtf
sst file:	2ILK.sst
tem file:	2ILK.tem