3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 2IF0

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00025 ADP-ribosylation factor family PF00025 PF00025

2 A PF00071 Ras family PF00071 PF00071

3 A PF08477 Miro-like protein PF08477 PF08477

4 A PF00009 Elongation factor Tu GTP binding domain PF00009 PF00009

Conserved Domain Database Superfamily Annotations: 2IF0

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 2IF0 206700 cd04127 Rab27A - cl09099

2 2IF0 212613 cl09099 P-loop_NTPase superfamily - -

Structural Details of PDB entry 2IF0

Structural Details of PDB entry 2IF0

PDBid Chains Hinge Swapped Domain

2IF0 A,B A:40-41,B:40-41 A:42-76,B:42-76

Swapped-domain interface residues and interactions:

Chains Residues
A 6, 7, 8, 9, 10, 11, 12, 14, 23, 30, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 53, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 88,

B 6, 7, 8, 9, 10, 11, 12, 14, 23, 30, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 51, 53, 65, 67, 68, 69, 70, 71, 72, 73, 74, 75, 88,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 17, 18, 22, 26, 27, 29, 32, 78, 79, 81, 82, 84, 87, 175, 178, 179, 182, 186, 189,

B 18, 22, 26, 27, 29, 32, 78, 79, 81, 82, 84, 87, 171, 174, 175, 178, 179, 182, 186,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation LEU(78)GLN, No mutation

B No mutation No mutation LEU(78)GLN, No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2IF0 B:2IF0

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 2IF0.ali
atm file: 2IF0.atm
cof file: 2IF0.cof
hbd file: 2IF0.hbd
html file: 2IF0.html
pdb file: 2IF0.pdb
ps file: 2IF0.ps
psa file: 2IF0.psa
rtf file: 2IF0.rtf
sst file: 2IF0.sst
tem file: 2IF0.tem