Pfam Domains mapped on to the structure: 2HXO

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF00440	Bacterial regulatory proteins, tetR family	PF00440	PF00440
2	A	PF02909	Tetracyclin repressor, C-terminal all-alpha domain	PF02909	PF02909

Conserved Domain Database Superfamily Annotations: 2HXO

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2HXO	212173	cl00088	HTH	superfamily - -

Structural Details of PDB entry 2HXO PDBid Chains Hinge Swapped Domain 2HXO A,B A:154-164,B:154-164 A:165-234,B:165-233 Swapped-domain interface residues and interactions: Chains Residues A 116, 119, 120, 125, 128, 129, 132, 133, 146, 147, 151, 165, 166, 182, 185, 186, 189, 190, 193, 197, 198, 199, 200, 201, 203, 204, 207, 208, 211, 216, 219, 220, 223, 224, 226, 227, 228, 230, 231, 234, B 112, 116, 119, 120, 125, 128, 129, 132, 133, 146, 147, 151, 165, 166, 182, 185, 186, 189, 190, 193, 197, 198, 199, 200, 201, 203, 204, 207, 208, 211, 216, 219, 220, 223, 224, 226, 227, 230, 231, Non-swapped-domain interface residues and interactions: Chains Residues A 112, 115, 124, 126, 136, 142, 143, 145, 150, 154, 155, 157, 158, 159, 162, B 115, 117, 124, 126, 136, 142, 143, 145, 150, 154, 155, 157, 158, 159, 162,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2HXO

B:2HXO

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2HXO.ali
atm file:	2HXO.atm
cof file:	2HXO.cof
hbd file:	2HXO.hbd
html file:	2HXO.html
pdb file:	2HXO.pdb
ps file:	2HXO.ps
psa file:	2HXO.psa
rtf file:	2HXO.rtf
sst file:	2HXO.sst
tem file:	2HXO.tem