Pfam Domains mapped on to the structure: 2HUW

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF00017	SH2 domain	PF00017	PF00017

Conserved Domain Database Superfamily Annotations: 2HUW

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2HUW	199828	cd09941	SH2_Grb2_like -	cl15255
2	2HUW	210054	cl15255	SH2	superfamily - -

Structural Details of PDB entry 2HUW PDBid Chains Hinge Swapped Domain 2HUW A,B A:63-65,B:63-65 A:55-62,B:56-62 Swapped-domain interface residues and interactions: Chains Residues A 55, 56, 57, 58, 59, 61, 62, B 56, 57, 58, 59, 61, 62, Non-swapped-domain interface residues and interactions: Chains Residues A 63, 64, 87, 92, 93, 95, 112, 115, 116, 118, 126, 127, 128, 129, 130, 153, 154, 155, B 63, 64, 65, 69, 73, 87, 92, 93, 95, 112, 116, 118, 126, 127, 128, 129, 130,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2HUW

B:2HUW

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2HUW.ali
atm file:	2HUW.atm
cof file:	2HUW.cof
hbd file:	2HUW.hbd
html file:	2HUW.html
pdb file:	2HUW.pdb
ps file:	2HUW.ps
psa file:	2HUW.psa
rtf file:	2HUW.rtf
sst file:	2HUW.sst
tem file:	2HUW.tem