Pfam Domains mapped on to the structure: 2HS1

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF00077	Retroviral aspartyl protease	PF00077	PF00077

Conserved Domain Database Superfamily Annotations: 2HS1

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2HS1	133149	cd05482	HIV_retropepsin_like -	cl11403
2	2HS1	209305	cl11403	pepsin_retropepsin_like	superfamily - -

Structural Details of PDB entry 2HS1 PDBid Chains Hinge Swapped Domain 2HS1 A,B A:7-9,B:7-9;A:107-109,B:107-109 A:1-6,B:1-6 Swapped-domain interface residues and interactions: Chains Residues A 1, 2, 3, 4, 5, 6, B 187, 191, 195, 196, 197, Non-swapped-domain interface residues and interactions: Chains Residues A 8, 9, 23, 24, 25, 26, 27, 29, 48, 49, 50, 51, 52, 54, 67, 69, 81, 84, 87, 90, 91, 93, 94, 95, 96, 97, 98, 99, B 101, 102, 103, 104, 105, 106, 107, 108, 109, 123, 124, 125, 126, 127, 129, 147, 149, 150, 151, 152, 154, 167, 169, 181, 184, 190, 192, 193, 194, 198,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	LYS(7)GLN,	No mutation	ALA(67)CYS, ALA(95)CYS,	No mutation
B	LYS(107)GLN,	ALA(195)CYS,	LYS(107)GLN, ALA(167)CYS,	No mutation
B	LYS(107)GLN,	ALA(195)CYS,	LYS(107)GLN, ALA(167)CYS,	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2HS1

B:2HS1

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2HS1.ali
atm file:	2HS1.atm
cof file:	2HS1.cof
hbd file:	2HS1.hbd
html file:	2HS1.html
pdb file:	2HS1.pdb
ps file:	2HS1.ps
psa file:	2HS1.psa
rtf file:	2HS1.rtf
sst file:	2HS1.sst
tem file:	2HS1.tem