Pfam Domains mapped on to the structure: 2HRW

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF13714	Phosphoenolpyruvate phosphomutase	PF13714	PF13714
2	A	PF00463	Isocitrate lyase family	PF00463	PF00463

Conserved Domain Database Superfamily Annotations: 2HRW

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2HRW	119340	cd00377	ICL_PEPM -	cl00435
2	2HRW	212216	cl00435	ICL_KPHMT	superfamily - -
3	2HRW	212216	cl00435	ICL_KPHMT	superfamily - -

Structural Details of PDB entry 2HRW PDBid Chains Hinge Swapped Domain 2HRW A,D A:50-54,D:50-54 A:1-49,D:1-49 Swapped-domain interface residues and interactions: Chains Residues A 18, 20, 23, 24, 25, 26, 27, 30, 31, 34, 35, 36, 44, 48, 49, 50, 51, 247, 250, 254, 272, 276, D 18, 20, 23, 24, 25, 26, 27, 30, 31, 34, 35, 36, 44, 48, 49, 50, 51, 247, 250, 254, 272, 276, Non-swapped-domain interface residues and interactions: Chains Residues A 52, 53, 55, 66, 69, 73, 116, 213, 216, 217, 219, 220, 234, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 249, 253, 257, 258, 259, 260, 263, 266, 267, 268, 269, 271, 273, 275, 277, 281, 285, 289, 290, D 52, 53, 55, 66, 69, 73, 116, 213, 216, 217, 219, 220, 234, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 249, 253, 257, 258, 259, 260, 263, 266, 267, 268, 269, 271, 273, 275, 277, 281, 285, 289,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
D	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2HRW

D:2HRW

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2HRW.ali
atm file:	2HRW.atm
cof file:	2HRW.cof
hbd file:	2HRW.hbd
html file:	2HRW.html
pdb file:	2HRW.pdb
ps file:	2HRW.ps
psa file:	2HRW.psa
rtf file:	2HRW.rtf
sst file:	2HRW.sst
tem file:	2HRW.tem