Pfam Domains mapped on to the structure: 2HMW

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF03446	NAD binding domain of 6-phosphogluconate dehydrogenase	PF03446	PF03446
2	A	PF02254	TrkA-N domain	PF02254	PF02254
3	A	PF13460	NADH(P)-binding	PF13460	PF13460

Conserved Domain Database Superfamily Annotations: 2HMW

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2HMW	212616	cl09931	NADB_Rossmann	superfamily - -

Structural Details of PDB entry 2HMW PDBid Chains Hinge Swapped Domain 2HMW A,B A:124-133,B:124-133 A:134-140,B:134-144 Swapped-domain interface residues and interactions: Chains Residues A 134, 135, 136, 137, 139, 140, B 134, 135, 136, 137, 139, 140, 141, Non-swapped-domain interface residues and interactions: Chains Residues A 8, 9, 16, 17, 20, 21, 24, 25, 28, 30, 73, 75, 101, 103, 105, 120, 122, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, B 8, 9, 16, 17, 20, 21, 24, 25, 28, 30, 73, 75, 101, 103, 105, 106, 120, 122, 124, 125, 126, 128, 129, 130, 131, 132, 133,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2HMW

B:2HMW

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2HMW.ali
atm file:	2HMW.atm
cof file:	2HMW.cof
hbd file:	2HMW.hbd
html file:	2HMW.html
pdb file:	2HMW.pdb
ps file:	2HMW.ps
psa file:	2HMW.psa
rtf file:	2HMW.rtf
sst file:	2HMW.sst
tem file:	2HMW.tem