Pfam Domains mapped on to the structure: 2HMS

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF03446	NAD binding domain of 6-phosphogluconate dehydrogenase	PF03446	PF03446
2	A	PF02254	TrkA-N domain	PF02254	PF02254
3	A	PF13460	NADH(P)-binding	PF13460	PF13460

Gene Ontology Annotations: 2HMS

No.	GO ID	GO Description	Linkout - AmiGO
1	GO:0055114	oxidation-reduction process	GO:0055114

Conserved Domain Database Superfamily Annotations: 2HMS

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2HMS	212616	cl09931	NADB_Rossmann	superfamily - -

Structural Details of PDB entry 2HMS PDBid Chains Hinge Swapped Domain 2HMS A,B A:124-137,B:124-137 A:138-144,B:138-140 Swapped-domain interface residues and interactions: Chains Residues A 139, 140, 141, 144, B 7, 139, Non-swapped-domain interface residues and interactions: Chains Residues A 7, 9, 16, 17, 20, 21, 24, 25, 28, 30, 73, 101, 103, 105, 120, 122, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, B 9, 16, 17, 20, 21, 24, 25, 28, 30, 73, 75, 101, 103, 105, 122, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2HMS

B:2HMS

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2HMS.ali
atm file:	2HMS.atm
cof file:	2HMS.cof
hbd file:	2HMS.hbd
html file:	2HMS.html
pdb file:	2HMS.pdb
ps file:	2HMS.ps
psa file:	2HMS.psa
rtf file:	2HMS.rtf
sst file:	2HMS.sst
tem file:	2HMS.tem